Monothiol glutaredoxins: a common domain for multiple functions
| dc.contributor.author | Herrero Perpiñán, Enrique | |
| dc.contributor.author | Torre Ruiz, M. A. de la | |
| dc.date.accessioned | 2014-07-25T09:25:29Z | |
| dc.date.available | 2014-07-25T09:25:29Z | |
| dc.date.issued | 2007 | |
| dc.identifier.issn | 1420-682X (versió paper) | |
| dc.identifier.issn | 1420-9071 | |
| dc.identifier.uri | http://hdl.handle.net/10459.1/47442 | |
| dc.description.abstract | Monothiol glutaredoxins with the CGFS sequence at the active site are widespread among prokaryotes and eukaryotes. Two subclasses exist, those with a single glutaredoxin domain and those with a thioredoxin-like region followed by one or more glutaredoxin domains. Studies in Saccharomyces cerevisiae have demonstrated the role of the Grx5 protein in the biogenesis of iron-sulphur clusters. Grx5 homologues in other eukaryotes could carry out similar functions. Two S. cerevisiae monothiol glutaredoxins with the thioredoxin-like extension, Grx3 and Grx4, are modulators of the transcriptional activator Aft1, which regulates iron uptake in yeast. The human PICOT protein is a Grx3/Grx4 homologue with the same hybrid primary structure, which regulates protein kinase C activity and may participate in physiological processes such as control of cardiac function. Therefore, monothiol glutaredoxins share a common basic structural motif and biochemical mechanism of action, while participating in a diversity of cellular functions as protein redox regulators. | ca_ES |
| dc.language.iso | eng | ca_ES |
| dc.publisher | Springer | ca_ES |
| dc.relation.isformatof | Versió preprint del document publicat a https://doi.org/10.1007/s00018-007-6554-8 | ca_ES |
| dc.relation.ispartof | Cellular and molecular life sciences : CMLS, 2007, vol. 64, núm. 12, p. 1518-1530 | ca_ES |
| dc.rights | (c) Birkhäuser Verlag, 2007 | ca_ES |
| dc.subject | Glutaredoxin | ca_ES |
| dc.subject | Estrès oxidatiu | ca_ES |
| dc.subject | Llevat de cervesa | ca_ES |
| dc.subject.other | Estrès oxidatiu | ca_ES |
| dc.subject.other | Saccharomyces cerevisiae | ca_ES |
| dc.title | Monothiol glutaredoxins: a common domain for multiple functions | ca_ES |
| dc.type | article | ca_ES |
| dc.identifier.idgrec | 011637 | |
| dc.type.version | submittedVersion | ca_ES |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_ES |
| dc.identifier.doi | https://doi.org/10.1007/s00018-007-6554-8 |
