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dc.contributor.authorHerrero Perpiñán, Enrique
dc.contributor.authorTorre Ruiz, M. A. de la
dc.date.accessioned2014-07-25T09:25:29Z
dc.date.available2014-07-25T09:25:29Z
dc.date.issued2007
dc.identifier.issn1420-682X (versió paper)
dc.identifier.issn1420-9071
dc.identifier.urihttp://hdl.handle.net/10459.1/47442
dc.description.abstractMonothiol glutaredoxins with the CGFS sequence at the active site are widespread among prokaryotes and eukaryotes. Two subclasses exist, those with a single glutaredoxin domain and those with a thioredoxin-like region followed by one or more glutaredoxin domains. Studies in Saccharomyces cerevisiae have demonstrated the role of the Grx5 protein in the biogenesis of iron-sulphur clusters. Grx5 homologues in other eukaryotes could carry out similar functions. Two S. cerevisiae monothiol glutaredoxins with the thioredoxin-like extension, Grx3 and Grx4, are modulators of the transcriptional activator Aft1, which regulates iron uptake in yeast. The human PICOT protein is a Grx3/Grx4 homologue with the same hybrid primary structure, which regulates protein kinase C activity and may participate in physiological processes such as control of cardiac function. Therefore, monothiol glutaredoxins share a common basic structural motif and biochemical mechanism of action, while participating in a diversity of cellular functions as protein redox regulators.ca_ES
dc.language.isoengca_ES
dc.publisherSpringerca_ES
dc.relation.isformatofVersió preprint del document publicat a https://doi.org/10.1007/s00018-007-6554-8ca_ES
dc.relation.ispartofCellular and molecular life sciences : CMLS, 2007, vol. 64, núm. 12, p. 1518-1530ca_ES
dc.rights(c) Birkhäuser Verlag, 2007ca_ES
dc.subjectGlutaredoxinca_ES
dc.subjectEstrès oxidatiuca_ES
dc.subjectLlevat de cervesaca_ES
dc.subject.otherEstrès oxidatiuca_ES
dc.subject.otherSaccharomyces cerevisiaeca_ES
dc.titleMonothiol glutaredoxins: a common domain for multiple functionsca_ES
dc.typearticleca_ES
dc.identifier.idgrec011637
dc.type.versionsubmittedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1007/s00018-007-6554-8


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