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dc.contributor.authorAhmad-Annuar, Azlina
dc.contributor.authorCiani, Lorenza
dc.contributor.authorSimeonidis, Iordanis
dc.contributor.authorHerreros Danés, Judit
dc.contributor.authorBen Fredj, Naila
dc.contributor.authorRosso, Silvana B.
dc.contributor.authorHall, Anita
dc.contributor.authorBrickley, Stephen
dc.contributor.authorSalinas, Patricia C.
dc.date.accessioned2014-06-20T13:38:12Z
dc.date.available2014-06-20T13:38:12Z
dc.date.issued2006
dc.identifier.issn0021-9525
dc.identifier.urihttp://hdl.handle.net/10459.1/47339
dc.description.abstractProper dialogue between presynaptic neurons and their targets is essential for correct synaptic assembly and function. At central synapses, Wnt proteins function as retrograde signals to regulate axon remodeling and the accumulation of presynaptic proteins. Loss of Wnt7a function leads to defects in the localization of presynaptic markers and in the morphology of the presynaptic axons. We show that loss of function of Dishevelled-1 (Dvl1) mimics and enhances the Wnt7a phenotype in the cerebellum. Although active zones appear normal, electrophysiological recordings in cerebellar slices from Wnt7a/Dvl1 double mutant mice reveal a defect in neurotransmitter release at mossy fi ber–granule cell synapses. Deficiency in Dvl1 decreases, whereas exposure to Wnt increases, synaptic vesicle recycling in mossy fi bers. Dvl increases the number of Bassoon clusters, and like other components of the Wnt pathway, it localizes to synaptic sites. These fi ndings demonstrate that Wnts signal across the synapse on Dvl-expressing presynaptic terminals to regulate synaptic assembly and suggest a potential novel function for Wnts in neurotransmitter release.ca_ES
dc.language.isoengca_ES
dc.publisherRockefeller University Pressca_ES
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1083/jcb.200511054ca_ES
dc.relation.ispartofJournal of Cell Biology, 2006, vol. 174, núm. 1, p.127-139ca_ES
dc.rights(c) Rockefeller University Press, 2006ca_ES
dc.subject.otherSistema nerviósca_ES
dc.subject.otherProteïnesca_ES
dc.subject.otherNeurotransmissorsca_ES
dc.titleSignaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter releaseca_ES
dc.typearticleca_ES
dc.identifier.idgrec009252
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1083/jcb.200511054


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