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dc.contributor.authorNi, Xiaohua
dc.contributor.authorZhang, Yonggang
dc.contributor.authorRibas i Fortuny, Judit
dc.contributor.authorChowdhury, Wasim H.
dc.contributor.authorCastanares, Mark
dc.contributor.authorZhang, Zhewei
dc.contributor.authorLaiho, Marikki
dc.contributor.authorDeWeese, Theodore L.
dc.contributor.authorLupold, Shawn E.
dc.date.accessioned2014-06-19T12:17:05Z
dc.date.available2014-06-19T12:17:05Z
dc.date.issued2011
dc.identifier.issn0021-9738
dc.identifier.urihttp://hdl.handle.net/10459.1/47333
dc.description.abstractDose-escalated radiation therapy for localized prostate cancer (PCa) has a clear therapeutic benefit; however, escalated doses may also increase injury to noncancerous tissues. Radiosensitizing agents can improve ionizing radiation (IR) potency, but without targeted delivery, these agents will also sensitize surrounding normal tissues. Here we describe the development of prostate-targeted RNAi agents that selectively sensitized prostate-specific membrane antigen–positive (PSMA-positive) cells to IR. siRNA library screens identified DNA-activated protein kinase, catalytic polypeptide (DNAPK) as an ideal radiosensitization target. DNAPK shRNAs, delivered by PSMA-targeting RNA aptamers, selectively reduced DNAPK in PCa cells, xenografts, and human prostate tissues. Aptamer-targeted DNAPK shRNAs, combined with IR, dramatically and specifically enhanced PSMA-positive tumor response to IR. These findings support aptamer-shRNA chimeras as selective sensitizing agents for the improved treatment of high-risk localized PCa.ca_ES
dc.language.isoengca_ES
dc.publisherAmerican Society for Clinical Investigationca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1172%2FJCI45109ca_ES
dc.relation.ispartofJournal of Clinical Investigation, 2011, vol. 121, núm. 6, p. 2383-2390ca_ES
dc.rights(c) American Society for Clinical Investigation, 2011ca_ES
dc.subject.otherTumorsca_ES
dc.subject.otherRadioteràpia
dc.subject.otherPròstata -- Càncer -- Tractament
dc.titleProstate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenograftsca_ES
dc.typearticleca_ES
dc.identifier.idgrec017837
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1172%2FJCI45109


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