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dc.contributor.authorAguilera, Mari
dc.contributor.authorArias Sampériz, Bárbara
dc.contributor.authorWichers, Marieke
dc.contributor.authorBarrantes Vidal, Neus
dc.contributor.authorMoya Higueras, Jorge
dc.contributor.authorVilla Martín, Elena
dc.contributor.authorOs, J. van (Jim van)
dc.contributor.authorIbáñez Ribes, Manuel Ignacio
dc.contributor.authorRuipérez Rodríguez, María Ángeles
dc.contributor.authorOrtet i Fabregat, Generós
dc.contributor.authorFañanás Saura, Lourdes
dc.date.accessioned2014-06-16T13:49:51Z
dc.date.available2014-06-16T13:49:51Z
dc.date.issued2009
dc.identifier.issn0033-2917
dc.identifier.urihttp://hdl.handle.net/10459.1/47321
dc.description.abstractAdverse childhood experiences have been described as one of the major environmental risk factors for depressive disorder. Likewise, the deleterious impact of early traumatic experiences on depression seems to be moderated by individual genetic variability. Serotonin transporter (5-HTT) and the Brain-Derived Neurotrophic Factor (BDNF) seem to modulate the effect of childhood adversity on adult depression, although inconsistencies across studies have been found. Moreover, the GxE interaction concerning the different types of childhood adversity remains poorly understood. The aim of this study is to analyse the putative interaction between the 5-HTT gene (5-HTTLPR polymorphism), BDNF gene (Val66Met polymorphism) and childhood adversity in accounting for adult depressive symptoms.ca_ES
dc.language.isoengca_ES
dc.publisherCambridge University Pressca_ES
dc.relation.isformatofVersió postprint del document publicat a:https://doi.org/10.1017/S0033291709005248ca_ES
dc.relation.ispartofPsychological medicine, 2009, vol. 39, núm. 9, p.1425-1432ca_ES
dc.rights(c) Cambridge University Press, 2009ca_ES
dc.subject5-HTTca_ES
dc.subjectBDNFca_ES
dc.subjectChildhood adversityca_ES
dc.subject.otherDepressió psíquicaca_ES
dc.titleEarly adversity and 5-HTT-BDNF genes: new evidences of gene-environment interactions on depressive symptoms in a general populationca_ES
dc.typearticleca_ES
dc.identifier.idgrec017657
dc.type.versionacceptedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1017/S0033291709005248


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