Early adversity and 5-HTT-BDNF genes: new evidences of gene-environment interactions on depressive symptoms in a general population

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2009
Author
Aguilera, Mari
Arias Sampériz, Bárbara
Wichers, Marieke
Barrantes Vidal, Neus
Moya Higueras, Jorge
Villa Martín, Elena
Os, J. van (Jim van)
Ibáñez Ribes, Manuel Ignacio
Ruipérez Rodríguez, María Ángeles
Ortet i Fabregat, Generós
Fañanás Saura, Lourdes
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Abstract
Adverse childhood experiences have been described as one of the major environmental risk factors for depressive disorder. Likewise, the deleterious impact of early traumatic experiences on depression seems to be moderated by individual genetic variability. Serotonin transporter (5-HTT) and the Brain-Derived
Neurotrophic Factor (BDNF) seem to modulate the effect of childhood adversity on adult depression, although inconsistencies across studies have been found. Moreover, the GxE interaction concerning the different types of childhood adversity remains poorly understood. The aim of this study is to analyse the putative interaction between the 5-HTT gene (5-HTTLPR polymorphism), BDNF gene (Val66Met polymorphism) and childhood adversity in accounting for adult depressive symptoms.
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http://hdl.handle.net/10459.1/47321
DOI
https://doi.org/10.1017/S0033291709005248
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Psychological medicine, 2009, vol. 39, núm. 9, p.1425-1432
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