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dc.contributor.authorFont de Mora, Jaime
dc.contributor.authorGil, Rosario
dc.contributor.authorSentandreu, Rafael
dc.contributor.authorHerrero Perpiñán, Enrique
dc.date.accessioned2014-05-15T15:43:44Z
dc.date.available2014-05-15T15:43:44Z
dc.date.issued1991
dc.identifier.issn0066-4804 (versió paper)
dc.identifier.issn1098-6596
dc.identifier.urihttp://hdl.handle.net/10459.1/47207
dc.description.abstractAculeacin A is a lipopeptide that inhibits ,B-glucan synthesis in yeasts. A number of Saccharomyces cerevisiae mutants resistant to this antibiotic were isolated, and four loci (ACRI, ACR2, ACR3, and ACR4) whose products are involved in the sensitivity to aculeacin A of yeast ceils were defined. Mutants containing mutations in the four loci were also resistant to echinocandin B, another member of this lipopeptide family of antibiotics. In contrast, acri, acr3, and acr4 mutants were resistant to papulacandin B (an antibiotic containing a disaccharide linked to two fatty acid chains that also inhibits P-glucan synthesis), but acr2 mutants were susceptible'to this antibiotic. This result defines common and specific steps in the entry and action of aculeacin A and papulacandin B. The analysis of double mutants revealed an epistatic effect of the acr2 mutation on the other three mutations. Cell walls of the four different mutants did not show significant alterations in composition with respect to the parental strain, and in vitro glucan synthase activity was also unaffected. However, cell surface hydrophobicity in three of the mutants was considerably decreased with respect to the parental strain.ca_ES
dc.language.isoengca_ES
dc.publisherAmerican Society for Microbiologyca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1128/AAC.35.12.2596ca_ES
dc.relation.ispartofAntimicrobial agents and chemotherapy, 1991, vol. 35, núm. 12, p. 2596-2601ca_ES
dc.rights(c) American Society for Microbiologyca_ES
dc.subjectLlevat de cervesaca_ES
dc.subjectAminoglicòsidca_ES
dc.subject.otherSaccharomyces cerevisiaeca_ES
dc.subject.otherAminoglucòsidsca_ES
dc.titleIsolation and characterization of Saccharomyces cerevisiae mutants resistant to aculeacin Aca_ES
dc.typearticleca_ES
dc.identifier.idgrec004187
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1128/AAC.35.12.2596


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