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dc.contributor.authorSoler Cantero, Arantza
dc.contributor.authorJové Font, Mariona
dc.contributor.authorCacabelos Barral, Daniel
dc.contributor.authorBoada Pallàs, Jordi
dc.contributor.authorNaudí i Farré, Alba
dc.contributor.authorRomero Fabregat, Mª Paz
dc.contributor.authorCassanyé, Anna
dc.contributor.authorSerrano Casasola, José Carlos Enrique
dc.contributor.authorArola i Ferrer, Lluís
dc.contributor.authorValls, Josep
dc.contributor.authorBellmunt i Curcó, Josepa
dc.contributor.authorPrat Corominas, Joan
dc.contributor.authorPamplona Gras, Reinald
dc.contributor.authorPortero Otín, Manuel
dc.contributor.authorMotilva Casado, Mª José
dc.date.accessioned2012-12-20T09:20:10Z
dc.date.available2012-12-20T09:20:10Z
dc.date.issued2012
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10459.1/46376
dc.description.abstractEpidemiological data suggest that plant-derived phenolics beneficial effects include an inhibition of LDL oxidation. After applying a screening method based on 2,4-dinitrophenyl hydrazine- protein carbonyl reaction to 21 different plant-derived phenolic acids, we selected the most antioxidant ones. Their effect was assessed in 5 different oxidation systems, as well as in other model proteins. Mass-spectrometry was then used, evidencing a heterogeneous effect on the accumulation of the structurally characterized protein carbonyl glutamic and aminoadipic semialdehydes as well as for malondialdehyde-lysine in LDL apoprotein. After TOF based lipidomics, we identified the most abundant differential lipids in Cu++-incubated LDL as 1-palmitoyllysophosphatidylcholine and 1-stearoyl-sn-glycero-3-phosphocholine. Most of selected phenolic compounds prevented the accumulation of those phospholipids and the cellular impairment induced by oxidized LDL. Finally, to validate these effects in vivo, we evaluated the effect of the intake of a phenolic-enriched extract in plasma protein and lipid modifications in a well-established model of atherosclerosis (diet-induced hypercholesterolemia in hamsters). This showed that a dietary supplement with a phenolic-enriched extract diminished plasma protein oxidative and lipid damage. Globally, these data show structural basis of antioxidant properties of plant-derived phenolic acids in protein oxidation that may be relevant for the health-promoting effects of its dietary intake. that a dietary supplement with a phenolic-enriched extract diminished plasma protein oxidative and lipid damage. Globally, these data show structural basis of antioxidant properties of plant-derived phenolic acids in protein oxidation that may be relevant for the health-promoting effects of its dietary intake.ca_ES
dc.description.sponsorshipThis study was supported in part by Research and Development grants from the Spanish Ministry of Education and Science (BFU2006-14495/BFI) and the Generalitat of Catalunya (2005SGR00101) to RP; the Spanish Ministry of Health (FIS 04-0355, 05-2214 and 05-2241) to MPO, Spanish Ministry of Education and Science (AGL2005-07881-C02-01 and AGL2006-12433) to MJM and MPO. Supported partially by the COST B-35 Action. The present work was supported by the CENIT program from the Spanish Minister of Industry and by a consortium of companies led by La Morella Nuts S. A. (Reus, Catalonia, Spain) with the following companies: Shirota Functional Foods, S. L.; KRAFT; BTSA, Biotecnologías Aplicadas, S. L.; Selección Batallé, S. A.; Industrial Técnica Pecuaria, S. A.; Neuron BioPharma, S. A.; Grupo Leche Pascual, S. A. U.; Innaves, S. A. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.language.isoengca_ES
dc.publisherPublic Library of Scienceca_ES
dc.relationMIECI/PN2004-2007/BFU2006-14495/BFI
dc.relationMIECI/PN2004-2007/AGL2005-07881-C02-01
dc.relationMIECI/PN2004-2007/AGL2006-12433
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0043308ca_ES
dc.relation.ispartofPLoS ONE, 2012, vol. 7, núm. 8, e43308ca_ES
dc.rightscc-by, (c) Soler-Cantero et al., 2012ca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/es/deed.caca_ES
dc.subject.otherAntioxidantsca_ES
dc.subject.otherFenolsca_ES
dc.subject.otherProteïnesca_ES
dc.subject.otherExtractes de plantesca_ES
dc.subject.otherOxidació fisiològicaca_ES
dc.subject.otherAliments funcionalsca_ES
dc.titlePlant-derived phenolics inhibit the accrual of structurally characterised protein and lipid oxidative modificationsca_ES
dc.typearticleca_ES
dc.identifier.idgrec018075
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0043308


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cc-by, (c) Soler-Cantero et al., 2012
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