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dc.contributor.authorDi Tommaso, Paolo
dc.contributor.authorMoretti, Sebastien
dc.contributor.authorXenarios, Ioannis
dc.contributor.authorOrobitg Cortada, Miquel
dc.contributor.authorMontañola Lacort, Alberto
dc.date.accessioned2012-12-11T10:05:27Z
dc.date.available2012-12-11T10:05:27Z
dc.date.issued2011
dc.identifier.issn0305-1048
dc.identifier.urihttp://hdl.handle.net/10459.1/46369
dc.description.abstractThis article introduces a new interface for T-Coffee, a consistency-based multiple sequence alignment program. This interface provides an easy and intuitive access to the most popular functionality of the package. These include the default T-Coffee mode for protein and nucleic acid sequences, the M-Coffee mode that allows combining the output of any other aligners, and template-based modes of T-Coffee that deliver high accuracy alignments while using structural or homology derived templates. These three available template modes are Expresso for the alignment of protein with a known 3D-Structure, R-Coffee to align RNA sequences with conserved secondary structures and PSI-Coffee to accurately align distantly related sequences using homology extension. The new server benefits from recent improvements of the T-Coffee algorithm and can align up to 150 sequences as long as 10 000 residues and is available from both http://www.tcoffee.org and its main mirror http://tcoffee.crg.cat.ca_ES
dc.description.sponsorshipFunding for open access charge: Plan Nacional (BFU2008-00419 to C.N. and P.D.T.); 7th Framework Programme of the European Commission, the LEISHDRUG (no 223414) and the Quantomics (KBBE-2A-222664) project; Computational resources are provided by the Center for Genomic Regulation (CRG) of Barcelona and the Vital-IT ( http://www.vital-it.ch ) Center for high-performance computing of the Swiss Institute of Bioinformatics; CUR of DIUE of GENCAT (to M.O. and A.M.); the Spanish ministry of education (TIN2008-05913); Consolider project (CSD 2007-00050);’ Super-computacion y e-Ciencia (SYEC)’.
dc.language.isoengca_ES
dc.publisherOxford University Pressca_ES
dc.relationMICINN/PN2008-2011/BFU2008-00419
dc.relationMICINN/PN2008-2011/TIN2008-05913
dc.relationMIECI/PN2004-2007/CSD 2007-00050
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1093/nar/gkr245ca_ES
dc.relation.ispartofNucleic Acids Research, 2011, vol. 39, supl. 2 (Web Server issue), W13-17ca_ES
dc.rightscc-by-nc, (c) Di Tommaso et al., 2011ca_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/es/deed.caca_ES
dc.subjectT-Coffeeca_ES
dc.subject.otherAlgorismes computacionalsca_ES
dc.subject.otherProcessament electrònic de dades -- Disseny de sistemesca_ES
dc.titleT-Coffee: a web server for the multiple sequence alignment of protein and RNA sequences using structural information and homology extensionca_ES
dc.typearticleca_ES
dc.identifier.idgrec017302
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1093/nar/gkr245
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/223414
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/KBBE-2A-222664


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cc-by-nc, (c) Di Tommaso et al., 2011
Except where otherwise noted, this item's license is described as cc-by-nc, (c) Di Tommaso et al., 2011