Show simple item record

dc.contributor.authorBermúdez López, Marcelino
dc.contributor.authorCeschia, Audrey
dc.contributor.authorPiccoli, Giacomo De
dc.contributor.authorColomina i Gabarrella, Neus
dc.contributor.authorPasero, Philippe
dc.contributor.authorAragón, Luis
dc.contributor.authorTorres Rosell, Jordi
dc.date.accessioned2012-12-11T09:12:11Z
dc.date.available2012-12-11T09:12:11Z
dc.date.issued2010
dc.identifier.issn0305-1048
dc.identifier.urihttp://hdl.handle.net/10459.1/46368
dc.description.abstractMitotic chromosome segregation requires the removal of physical connections between sister chromatids. In addition to cohesin and topological entrapments, sister chromatid separation can be prevented by the presence of chromosome junctions or ongoing DNA replication. We will collectively refer to them as DNA-mediated linkages. Although this type of structures has been documented in different DNA replication and repair mutants, there is no known essential mechanism ensuring their timely removal before mitosis. Here, we show that the dissolution of these connections is an active process that requires the Smc5/6 complex, together with Mms21, its associated SUMO-ligase. Failure to remove DNA-mediated linkages causes gross chromosome missegregation in anaphase. Moreover, we show that Smc5/6 is capable to dissolve them in metaphase-arrested cells, thus restoring chromosome resolution and segregation. We propose that Smc5/6 has an essential role in the removal of DNA-mediated linkages to prevent chromosome missegregation and aneuploidy.ca_ES
dc.language.isoengca_ES
dc.publisherOxford University Pressca_ES
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1093/nar/gkq546ca_ES
dc.relation.ispartofNucleic Acids Research, 2010, vol. 38, núm. 19, p. 6502-6512ca_ES
dc.rightscc-by-nc, (c) Bermúdez-López et al., 2010ca_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc/2.5/es/deed.caca_ES
dc.subject.otherADNca_ES
dc.subject.otherCromosomesca_ES
dc.subject.otherGenèticaca_ES
dc.titleThe Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkagesca_ES
dc.typearticleca_ES
dc.identifier.idgrec017154
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1093/nar/gkq546


Files in this item

Thumbnail
Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

cc-by-nc, (c) Bermúdez-López et al., 2010
Except where otherwise noted, this item's license is described as cc-by-nc, (c) Bermúdez-López et al., 2010