Contribution of early detection and adjuvant treatments to breast cancer mortality reduction in Catalonia, Spain
Data de publicació2012
MetadadesMostra el registre d'unitat complet
Background: Reductions in breast cancer (BC) mortality in Western countries have been attributed to the use of screening mammography and adjuvant treatments. The goal of this work was to analyze the contributions of both interventions to the decrease in BC mortality between 1975 and 2008 in Catalonia.
Methodology/Principal Findings: A stochastic model was used to quantify the contribution of each intervention. Age standardized BC mortality rates for calendar years 1975-2008 were estimated in four hypothetical scenarios: 1) Only screening, 2) Only adjuvant treatment, 3) Both interventions, and 4) No intervention. For the 30-69 age group, observed Catalan BC mortality rates per 100,000 women-year rose from 29.4 in 1975 to 38.3 in 1993, and afterwards continuously decreased to 23.2 in 2008. If neither of the two interventions had been used, in 2008 the estimated BC mortality would have been 43.5, which, compared to the observed BC mortality rate, indicates a 46.7% reduction. In 2008 the reduction attributable to screening was 20.4%, to adjuvant treatments was 15.8% and to both interventions 34.1%. Conclusions/Significance: Screening and adjuvant treatments similarly contributed to reducing BC mortality in Catalonia. Mathematical models have been useful to assess the impact of interventions addressed to reduce BC mortality that occurred over nearly the same periods.
És part dePLoS ONE, 2011, vol. 7, núm. 1, e30157
Els fitxers de llicència següents estan associats amb aquest element:
Aquest document està subjecte a una llicència Creative Commons.cc-by, (c) Vilaprinyo, Puig, Rue, 2012
Mostrant elements relacionats per títol, autor i matèria.
Rué i Monné, Montserrat; Vilaprinyo Terré, Ester; Lee, Sandra; Martínez Alonso, Montserrat; Carles Lavila, Misericordia; Marcos-Gragera, Rafael; Pla, Roger; Espinàs, Josep Alfons (BioMed Central, 2009)Background: At present, it is complicated to use screening trials to determine the optimal age intervals and periodicities of breast cancer early detection. Mathematical models are an alternative that has been widely used. ...
Carles Lavila, Misericordia; Vilaprinyo Terré, Ester; Cots, Francesc; Gregori Gomis, Aleix; Pla Farnós, Roger; Román, Rubén; Sala i Serra, Maria; Macià, Francesc; Castells, Xavier; Rué i Monné, Montserrat (BioMed Central, 2011)Background: Breast cancer (BC) causes more deaths than any other cancer among women in Catalonia. Early detection has contributed to the observed decline in BC mortality. However, there is debate on the optimal screening ...
Vilaprinyo Terré, Ester; Gispert i Magarolas, Rosa; Martínez Alonso, Montserrat; Carles Lavila, Misericordia; Pla, Roger; Espinàs, Josep Alfons; Rué i Monné, Montserrat (BioMed Central, 2008)Background: Breast cancer mortality has experienced important changes over the last century. Breast cancer occurs in the presence of other competing risks which can influence breast cancer incidence and mortality trends. ...