Colonic perianastomotic carcinogenesis in an experimental model

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2008Suggested citation
Pérez-Holanda Fernández, Sergio;
Rodrigo, Luis;
Piñol Felis, Carme;
Viñas Salas, Joan;
.
(2008)
.
Colonic perianastomotic carcinogenesis in an experimental model.
BMC Cancer, 2008, vol. 8, núm. 217, p.1-6.
https://doi.org/10.1186%2F1471-2407-8-217.
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Show full item recordAbstract
Background
To examine the effect of anastomosis on experimental carcinogenesis in the colon of rats.
Methods
Forty-three 10-week-old male and female Sprague-Dawley rats were operated on by performing an end-to-side ileorectostomy. Group A:16 rats received no treatment. Group B: 27 rats received 18 subcutaneous injections weekly at a dose of 21 mg/kg wt of 1–2 dimethylhydrazine (DMH), from the eighth day after the intervention. Animals were sacrificed between 25–27 weeks. The number of tumours, their localization, size and microscopic characteristics were recorded. A paired chi-squared analysis was performed comparing tumoral induction in the perianastomotic zone with the rest of colon with faeces.
Results
No tumours appeared in the dimethylhydrazine-free group. The percentage tumoral area was greater in the perianastomotic zone compared to tumours which had developed in the rest of colon with faeces (p = 0.014).
Conclusion
We found a cocarcinogenic effect due to the creation of an anastomosis, when using an experimental model of colonic carcinogenesis induced by DMH in rats.
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BMC Cancer, 2008, vol. 8, núm. 217, p.1-6European research projects
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