Colonic perianastomotic carcinogenesis in an experimental model

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2008
Author
Pérez-Holanda Fernández, Sergio
Rodrigo, Luis
Piñol Felis, Carme
Viñas Salas, Joan
Suggested citation
Pérez-Holanda Fernández, Sergio; Rodrigo, Luis; Piñol Felis, Carme; Viñas Salas, Joan; . (2008) . Colonic perianastomotic carcinogenesis in an experimental model. BMC Cancer, 2008, vol. 8, núm. 217, p.1-6. https://doi.org/10.1186%2F1471-2407-8-217.
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Abstract
Background To examine the effect of anastomosis on experimental carcinogenesis in the colon of rats. Methods Forty-three 10-week-old male and female Sprague-Dawley rats were operated on by performing an end-to-side ileorectostomy. Group A:16 rats received no treatment. Group B: 27 rats received 18 subcutaneous injections weekly at a dose of 21 mg/kg wt of 1–2 dimethylhydrazine (DMH), from the eighth day after the intervention. Animals were sacrificed between 25–27 weeks. The number of tumours, their localization, size and microscopic characteristics were recorded. A paired chi-squared analysis was performed comparing tumoral induction in the perianastomotic zone with the rest of colon with faeces. Results No tumours appeared in the dimethylhydrazine-free group. The percentage tumoral area was greater in the perianastomotic zone compared to tumours which had developed in the rest of colon with faeces (p = 0.014). Conclusion We found a cocarcinogenic effect due to the creation of an anastomosis, when using an experimental model of colonic carcinogenesis induced by DMH in rats.
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http://hdl.handle.net/10459.1/345
DOI
https://doi.org/10.1186%2F1471-2407-8-217
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BMC Cancer, 2008, vol. 8, núm. 217, p.1-6
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Except where otherwise noted, this item's license is described as cc-by, (c) Pérez-Holanda et al., 2008