Now showing items 1-8 of 8

    • Can the world afford to ignore biotechnology solutions that address food insecurity? 

      Berman Quintana, Judit; Zhu, Changfu; Pérez Massot, Eduard; Arjó Pont, Gemma; Zorrilla López, Uxue; Masip Vilà, Gemma; Banakar, Raviraj; Sanahuja Solsona, Georgina; Farré Martinez, Gemma; Miralpeix i Anglada, Bruna; Bai, Chao; Vamvaka, Evangelia; Sabalza Gallués, Maite; Twyman, Richard M.; Bassie Rene, Ludovic; Capell Capell, Teresa; Christou, Paul (Springer Verlag, 2013)
      Genetically engineered (GE) crops can be used as part of a combined strategy to address food insecurity, which is defined as a lack of sustainable access to safe and nutritious food. In this article, we discuss the ...
    • Cyanovirin-N produced in rice endosperm offers effective pre-exposure prophylaxis against HIV-1BaL infection in vitro 

      Vamvaka, Evangelia; Evans, Abbey; Ramessar, Koreen; Krumpe, L. R. H.; Shattock, Robin J.; O’Keefe, Barry R.; Christou, Paul; Capell Capell, Teresa (Springer Berlin Heidelberg, 2016)
      Cyanovirin-N (CV-N) is a lectin with potent antiviral activity that has been proposed as a component of microbicides for the prevention of infection with Human immunodeficiency virus (HIV). The production of protein-based ...
    • Engineering metabolic pathways in plants by multigene transformation 

      Zorrilla López, Uxue; Masip Vilà, Gemma; Arjó Pont, Gemma; Bai, Chao; Banakar, Raviraj; Bassie Rene, Ludovic; Berman Quintana, Judit; Farré Martinez, Gemma; Miralpeix i Anglada, Bruna; Pérez Massot, Eduard; Sabalza Gallués, Maite; Sanahuja Solsona, Georgina; Vamvaka, Evangelia; Twyman, Richard M.; Christou, Paul; Zhu, Changfu; Capell Capell, Teresa (University of the Basque Country Press, 2013)
      Metabolic engineering in plants can be used to increase the abundance of specific valuable metabolites, but single-point interventions generally do not improve the yields of target metabolites unless that product is ...
    • Rice endosperm is cost-effective for the production of recombinant griffithsin with potent activity against HIV 

      Vamvaka, Evangelia; Arcalis, Elsa; Ramessar, Koreen; Evans, Abbey; O’Keefe, Barry R.; Shattock, Robin J.; Medina Piles, Vicente; Stöger, Eva; Christou, Paul; Capell Capell, Teresa (Wiley, 2016)
      Protein microbicides containing neutralizing antibodies and antiviral lectins may help to reduce the rate of infection with human immunodeficiency virus (HIV) if it is possible to manufacture the components in large ...
    • Rice endosperm produces an underglycosylated and potent form of the HIV-neutralizing monoclonal antibody 2G12 

      Vamvaka, Evangelia; Twyman, Richard M.; Melro Murad, Andre; Melnik, Stanislav; Yi-Hui Teh, Audrey; Arcalis, Elsa; Altmann, Friedrich; Stöger, Eva; Rech, Elibio; Ma, Julian K-C.; Christou, Paul; Capell Capell, Teresa (Wiley, 2016)
      Protein microbicides against HIV can help to prevent infection but they are required in large, repetitive doses. This makes current fermenter-based production systems prohibitively expensive. Plants are advantageous as ...
    • Seeds as a production system for molecular pharming applications: status and prospects 

      Sabalza Gallués, Maite; Vamvaka, Evangelia; Christou, Paul; Capell Capell, Teresa (Bentham Science Publishers, 2013)
      The production of recombinant proteins in seeds is achieved by driving transgene expression using promoters and protein targeting sequences derived from genes encoding abundant seed storage proteins. This approach is ...
    • The contribution of transgenic plants to better health through improved nutrition: opportunities and constraints 

      Pérez Massot, Eduard; Banakar, Raviraj; Gómez Galera, Sonia; Zorrilla López, Uxue; Sanahuja Solsona, Georgina; Arjó Pont, Gemma; Miralpeix i Anglada, Bruna; Vamvaka, Evangelia; Farré Martinez, Gemma; Rivera Vélez, Sol Maiam; Dashevskaya, Svetlana; Berman Quintana, Judit; Sabalza Gallués, Maite; Yuan, Dawei; Bai, Chao; Bassie Rene, Ludovic; Twyman, Richard M.; Capell Capell, Teresa; Christou, Paul; Zhu, Changfu (Springer Verlag, 2013)
      Malnutrition is a prevalent and entrenched global socioeconomic challenge that reflects the combined impact of poverty, poor access to food, inefficient food distribution infrastructure, and an over-reliance on ...
    • Unexpected synergistic HIV neutralization by a triple microbicide produced in rice endosperm 

      Vamvaka, Evangelia; Farré Martinez, Gemma; Molinos-Albert, Luis M.; Evans, Abbey; Canela Xandri, Anna; Twyman, Richard M.; Carrillo, Jorge; Ordóñez, Raziel Antonio; Shattock, Robin J.; O’Keef, Barry R.; Clotet, Bonaventura; Blanco, Julian; Khush, Gurdev S.; Christou, Paul; Capell Capell, Teresa (National Academy of Sciences, 2018-08-14)
      The transmission of HIV can be prevented by the application of neutralizing monoclonal antibodies and lectins. Traditional recombinant protein manufacturing platforms lack sufficient capacity and are too expensive for ...