Now showing items 1-20 of 28

    • A golden era—pro-vitamin A enhancement in diverse crops 

      Bai, Chao; Twyman, Richard M.; Farré Martinez, Gemma; Sanahuja Solsona, Georgina; Christou, Paul; Capell Capell, Teresa; Zhu, Changfu (Springer Verlag, 2011)
      Numerous crops have been bred or engineered to increase carotenoid levels in an effort to develop novel strategies that address vitamin A deficiency in the developing world. The pioneering work in rice (not covered in ...
    • A question of balance: achieving appropriate nutrient levels in biofortified staple crops 

      Sanahuja Solsona, Georgina; Farré Martinez, Gemma; Berman Quintana, Judit; Zorrilla López, Uxue; Twyman, Richard M.; Capell Capell, Teresa; Christou, Paul; Zhu, Changfu (Cambridge University Press, 2013)
      The biofortification of staple crops with vitamins is an attractive strategy to increase the nutritional quality of human food, particularly in areas where the population subsists on a cereal-based diet. Unlike other ...
    • Bacillus thuringiensis: a century of research, development and commercial applications 

      Sanahuja Solsona, Georgina; Banakar, Raviraj; Twyman, Richard M.; Capell Capell, Teresa; Christou, Paul (Wiley, 2011)
      Bacillus thuringiensis (Bt) is a soil bacterium that forms spores during the stationary phase of its growth cycle. The spores contain crystals, predominantly comprising one or more Cry and/or Cyt proteins (also known as ...
    • Biofortification of crops with nutrients: factors affecting utilization and storage 

      Díaz Gómez, Joana; Twyman, Richard M.; Zhu, Changfu; Farré Martinez, Gemma; Serrano Casasola, José Carlos Enrique; Portero Otín, Manuel; Muñoz Odina, Mª Pilar; Sandmann, Gerhard; Capell Capell, Teresa; Christou, Paul (Elsevier, 2017-01-06)
      Biofortification is an effective and economical method to improve the micronutrient content of crops, particularly staples that sustain human populations in developing countries. Whereas conventional fortification requires ...
    • Calling the tunes on transgenic crops: the case for regulatory harmony 

      Ramessar, Koreen; Capell Capell, Teresa; Twyman, Richard M.; Quemada, Hector; Christou, Paul (Springer Verlag, 2009)
      Genetically modified (GM) crops are now grown commercially in 23 countries, with another 29 granting approval for import and release into the environment. Despite the socio-economic and environmental benefits of the ...
    • Can the world afford to ignore biotechnology solutions that address food insecurity? 

      Berman Quintana, Judit; Zhu, Changfu; Pérez Massot, Eduard; Arjó Pont, Gemma; Zorrilla López, Uxue; Masip Vilà, Gemma; Banakar, Raviraj; Sanahuja Solsona, Georgina; Farré Martinez, Gemma; Miralpeix i Anglada, Bruna; Bai, Chao; Vamvaka, Evangelia; Sabalza Gallués, Maite; Twyman, Richard M.; Bassie Rene, Ludovic; Capell Capell, Teresa; Christou, Paul (Springer Verlag, 2013)
      Genetically engineered (GE) crops can be used as part of a combined strategy to address food insecurity, which is defined as a lack of sustainable access to safe and nutritious food. In this article, we discuss the ...
    • Characteristics of genome editing mutations in cereal crops 

      Zhu, Changfu; Bortesi, Luisa; Baysal, Can; Twyman, Richard M.; Fischer, Rainer; Capell Capell, Teresa; Schillberg, Stefan; Christou, Paul (Elsevier, 2017)
      Designer nucleases allow the creation of new plant genotypes by introducing precisely-targeted double-strand breaks that are resolved by endogenous repair pathways. The major nuclease technologies are meganucleases, ...
    • Contributions of the international plant science community to the fight against infectious diseases in humans - part 1: epidemic and pandemic diseases, including HIV/AIDS and coronaviruses 

      Lobato, Maria; Huang, Xin; Alvarez, Derry; He, Wenshu; Baysal, Can; Zhu, Changfu; Armario-Nájera, Victoria; Blanco Perera, Amaya; Cerda, Pedro; Saba-Mayoral, Andrea; Sobrino-Mengual, Guillermo; Vargheese, Ashwin; Abranches, Rita; Abreu, Isabel Alexandra; Balamurugan, Shanmugaraj; Bock, Ralph; Buyel, Johannes F.; Cunha, Nicolau B. da; Daniell, Henry; Faller, Roland; Folgado, André; Gowtham, Iyappan; Häkkinen, Suvi; Kumar, Shashi; Sathish Kumar, Ramalingam; Lacorte, Cristiano; Lomonossoff, George P.; Luís, Ines M.; Ma, Julian K-C; McDonald, Karen A.; Murad, Andre; Nandi, Somen; O'Keef, Barry; Oksman-Caldentey, Kirsi-Marja; Parthiban, Subramanian; Paul, Mathew J.; Ponndorf, Daniel; Rech, Elibio; Rodrigues, Julio C. M.; Ruf, Stephanie; Schillberg, Stefan; Schwestka, Jennifer; Shah, Priya S.; Singh, Rahul; Stoger, Eva; Twyman, Richard M.; Varghese, Inchakalody P.; Vianna, Giovanni R.; Webster, Gina; Wilbers, Ruud H. P.; Capell Capell, Teresa; Christou, Paul (Wiley, 2021-04-06)
      Infectious diseases, also known as transmissible or communicable diseases, are caused by pathogens or parasites that spread in communities by direct contact with infected individuals or contaminated materials, through ...
    • Contributions of the international plant science community to the fight against infectious diseases in humans - part 2: endemic and re-emerging diseases 

      He, Wenshu; Baysal, Can; Lobato, Maria; Huang, Xin; Alvarez, Derry; Zhu, Changfu; Armario-Nájera, Victoria; Blanco Perera, Amaya; Cerda, Pedro; Saba-Mayoral, Andrea; Sobrino-Mengual, Guillermo; Vargheese, Ashwin; Abranches, Rita; Abreu, Isabel Alexandra; Balamurugan, Shanmugaraj; Bock, Ralph; Buyel, Johannes F.; Cunha, Nicolau B. da; Daniell, Henry; Faller, Roland; Folgado, André; Gowtham, Iyappan; Häkkinen, Suvi; Kumar, Shashi; Sathish Kumar, Ramalingam; Lacorte, Cristiano; Lomonossoff, George P.; Luís, Ines M.; Ma, Julian K-C; McDonald, Karen A.; Murad, Andre; Nandi, Somen; O'Keef, Barry; Parthiban, Subramanian; Paul, Mathew J.; Ponndorf, Daniel; Rech, Elibio; Rodrigues, Julio C. M.; Ruf, Stephanie; Schillberg, Stefan; Schwestka, Jennifer; Shah, Priya S.; Singh, Rahul; Stoger, Eva; Twyman, Richard M.; Varghese, Inchakalody P.; Vianna, Giovanni R.; Webster, Gina; Wilbers, Ruud H. P.; Christou, Paul; Oksman-Caldentey, Kirsi-Marja; Capell Capell, Teresa (Wiley, 2021-04-06)
      The fight against infectious diseases often focuses on epidemics and pandemics, which demand urgent resources and command attention from the health authorities and media. However, the vast majority of deaths caused by ...
    • Engineering metabolic pathways in plants by multigene transformation 

      Zorrilla López, Uxue; Masip Vilà, Gemma; Arjó Pont, Gemma; Bai, Chao; Banakar, Raviraj; Bassie Rene, Ludovic; Berman Quintana, Judit; Farré Martinez, Gemma; Miralpeix i Anglada, Bruna; Pérez Massot, Eduard; Sabalza Gallués, Maite; Sanahuja Solsona, Georgina; Vamvaka, Evangelia; Twyman, Richard M.; Christou, Paul; Zhu, Changfu; Capell Capell, Teresa (University of the Basque Country Press, 2013)
      Metabolic engineering in plants can be used to increase the abundance of specific valuable metabolites, but single-point interventions generally do not improve the yields of target metabolites unless that product is ...
    • Field trials and tribulations—making sense of the regulations for experimental field trials of transgenic crops in Europe 

      Gómez Galera, Sonia; Twyman, Richard M.; Sparrow, Penelope A.C.; Van Droogenbroeck, Bart; Custers, René; Capell Capell, Teresa; Christou, Paul (Wiley, 2012)
      Transgenic plants that are being developed for commercial cultivation must be tested underfield conditions to monitor their effects on surrounding wildlife and conventional crops. Devel-opers also use this opportunity to ...
    • High-carotenoid maize: development of plant biotechnology prototypes for human and animal health and nutrition 

      Zhu, Changfu; Farré Martinez, Gemma; Zanga, Daniela; Lloveras Vilamanyà, Jaume; Michelena Bárcena, Antonio; Ferrio Díaz, Juan Pedro; Voltas Velasco, Jordi; Slafer, Gustavo A.; Savin, Roxana; Albajes Garcia, Ramon; Eizaguirre Altuna, Matilde; López Alonso, Carmen; Cantero-Martínez, Carlos; Díaz Gómez, Joana; Nogareda, Carmina; Moreno Martínez, José Antonio; Angulo Asensio, Eduardo; Estany Illa, Joan; Pena i Subirà, Ramona Natacha; Tor i Naudí, Marc; Portero Otín, Manuel; Eritja Sánchez, Núria; Arjó Pont, Gemma; Serrano Casasola, José Carlos Enrique; Matias-Guiu, Xavier; Twyman, Richard M.; Sandmann, Gerhard; Capell Capell, Teresa; Christou, Paul (Springer Verlag, 2017-06-01)
      Carolight® is a transgenic maize variety that accumulates extraordinary levels of carotenoids, including those with vitamin A activity. The development of Carolight® maize involved the technical implementation of a novel ...
    • High-value products from transgenic maize 

      Naqvi, Shaista; Ramessar, Koreen; Farré Martinez, Gemma; Sabalza Gallués, Maite; Miralpeix i Anglada, Bruna; Twyman, Richard M.; Capell Capell, Teresa; Zhu, Changfu; Christou, Paul (Elsevier, 2011)
      Maize (also known as corn) is a domesticated cereal grain that has been grown as food and animal feed for tens of thousands of years. It is currently the most widely grown crop in the world, and is used not only for food/feed ...
    • Nutritionally enhanced crops and food security: scientific achievements versus political expediency 

      Farré Martinez, Gemma; Twyman, Richard M.; Zhu, Changfu; Capell Capell, Teresa; Christou, Paul (Elsevier, 2011)
      Genetic engineering (GE) is one of a raft of strategies that can be used to tackle malnutrition. Recent scientific advances have shown that multiple deficiencies can be tackled simultaneously using engineered plant varieties ...
    • Nutritious crops producing multiple carotenoids – a metabolic balancing act 

      Farré Martinez, Gemma; Bai, Chao; Twyman, Richard M.; Capell Capell, Teresa; Christou, Paul; Zhu, Changfu (Elsevier, 2011)
      Plants and microbes produce multiple carotenoid pigments with important nutritional roles in animals. By unraveling the basis of carotenoid biosynthesis it has become possible to modulate the key metabolic steps in plants ...
    • Paradoxical EU agricultural policies on genetically engineered crops 

      Masip Vilà, Gemma; Sabalza Gallués, Maite; Pérez Massot, Eduard; Banakar, Raviraj; Cebrian, David; Twyman, Richard M.; Capell Capell, Teresa; Albajes Garcia, Ramon; Christou, Paul (Elsevier, 2013)
      European Union (EU) agricultural policy has been developed in the pursuit of laudable goals such as a competitive economy and regulatory harmony across the union. However, what has emerged is a fragmented, contradictory, and ...
    • Patterns of CRISPR/Cas9 activity in plants, animals and microbes 

      Bortesi, Luisa; Zhu, Changfu; Zischewski, Julia; Pérez Álvarez, Lucía; Bassie Rene, Ludovic; Nadi, Riad; Forni, Giobbe; Lade Lee, Sarah Boyd; Soto, Erika; Jin, Xin; Medina Piles, Vicente; Villorbina Noguera, Gemma; Muñoz Gràcia, Pilar; Farré Martinez, Gemma; Fischer, Rainer; Twyman, Richard M.; Capell Capell, Teresa; Christou, Paul; Schillberg, Stefan (Wiley, 2016)
      The CRISPR/Cas9 system and related RNA-guided endonucleases can introduce double-strand breaks (DSBs) at specific sites in the genome, allowing the generation of targeted mutations in one or more genes as well as more ...
    • Plant biotechnology: the importance of being accurate 

      Twyman, Richard M.; Ramessar, Koreen; Quemada, Hector; Capell Capell, Teresa; Christou, Paul (Elsevier, 2009)
    • Promoter diversity in multigene transformation 

      Peremartí, Ariadna; Twyman, Richard M.; Gómez Galera, Sonia; Naqvi, Shaista; Farré Martinez, Gemma; Sabalza Gallués, Maite; Miralpeix i Anglada, Bruna; Dashevskaya, Svetlana; Yuan, Dawei; Ramessar, Koreen; Christou, Paul; Zhu, Changfu; Bassie Rene, Ludovic; Capell Capell, Teresa (Springer Verlag, 2010)
      Multigene transformation (MGT) is becoming routine in plant biotechnology as researchers seek to generate more complex and ambitious phenotypes in transgenic plants. Every nuclear transgene requires its own promoter, ...
    • Regulatory approval and a first-in-human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants 

      Ma, Julian K-C.; Drossard, Jürgen; Lewis, David; Altmann, Friedrich; Boyle, Julia; Christou, Paul; Cole, Tom; Dale, Philip; van Dolleweerd, Craig J.; Isitt, Valerie; Katinger, Dietmar; Lobedan, Martin; Mertens, Hubert; Paul, Mathew; Rademacher, Thomas; Sack, Markus; Hundleby, Penelope A. C.; Stiegler, Gabriela; Stöger, Eva; Twyman, Richard M.; Vcelar, Brigitta; Fischer, Rainer (Wiley, 2015)
      Although plant biotechnology has been widely investigated for the production of clinical-grade monoclonal antibodies, no antibody products derived from transgenic plants have yet been approved by pharmaceutical regulators ...