Now showing items 1-20 of 31

    • A golden era—pro-vitamin A enhancement in diverse crops 

      Bai, Chao; Twyman, Richard M.; Farré Martinez, Gemma; Sanahuja Solsona, Georgina; Christou, Paul; Capell Capell, Teresa; Zhu, Changfu (Springer Verlag, 2011)
      Numerous crops have been bred or engineered to increase carotenoid levels in an effort to develop novel strategies that address vitamin A deficiency in the developing world. The pioneering work in rice (not covered in ...
    • A question of balance: achieving appropriate nutrient levels in biofortified staple crops 

      Sanahuja Solsona, Georgina; Farré Martinez, Gemma; Berman Quintana, Judit; Zorrilla López, Uxue; Twyman, Richard M.; Capell Capell, Teresa; Christou, Paul; Zhu, Changfu (Cambridge University Press, 2013)
      The biofortification of staple crops with vitamins is an attractive strategy to increase the nutritional quality of human food, particularly in areas where the population subsists on a cereal-based diet. Unlike other ...
    • Ascorbic acid synthesis and metabolism in maize are subject to complex and genotype-dependent feedback regulation duringendosperm development 

      Sanahuja Solsona, Georgina; Farré Martinez, Gemma; Bassie Rene, Ludovic; Zhu, Changfu; Christou, Paul; Capell Capell, Teresa (Wiley, 2013)
      L-ascorbic acid (vitamin C) is an antioxidant and electron donor whose metabolism in plants isunder strict feedback control. The factors that influence L-ascorbic acid accumulation in staplecrops are only partially understood. ...
    • Biofortification of crops with nutrients: factors affecting utilization and storage 

      Díaz Gómez, Joana; Twyman, Richard M.; Zhu, Changfu; Farré Martinez, Gemma; Serrano Casasola, José Carlos Enrique; Portero Otín, Manuel; Muñoz Odina, Mª Pilar; Sandmann, Gerhard; Capell Capell, Teresa; Christou, Paul (Elsevier, 2017-01-06)
      Biofortification is an effective and economical method to improve the micronutrient content of crops, particularly staples that sustain human populations in developing countries. Whereas conventional fortification requires ...
    • Biofortification of plants with altered antioxidant content and composition: genetic engineering strategies 

      Changfu, Zhu; Sanahuja Solsona, Georgina; Yuan, Dawei; Farré Martinez, Gemma; Arjó Pont, Gemma; Berman Quintana, Judit; Zorrilla López, Uxue; Banakar, Raviraj; Bai, Chao; Pérez Massot, Eduard; Bassie Rene, Ludovic; Capell Capell, Teresa; Christou, Paul (Wiley Open Access, 2013)
      Antioxidants are protective molecules that neutralize reactive oxygen species and prevent oxidative damage to cellular components such as membranes, proteins and nucleic acids, therefore reducing the rate of cell death ...
    • Can the world afford to ignore biotechnology solutions that address food insecurity? 

      Berman Quintana, Judit; Zhu, Changfu; Pérez Massot, Eduard; Arjó Pont, Gemma; Zorrilla López, Uxue; Masip Vilà, Gemma; Banakar, Raviraj; Sanahuja Solsona, Georgina; Farré Martinez, Gemma; Miralpeix i Anglada, Bruna; Bai, Chao; Vamvaka, Evangelia; Sabalza Gallués, Maite; Twyman, Richard M.; Bassie Rene, Ludovic; Capell Capell, Teresa; Christou, Paul (Springer Verlag, 2013)
      Genetically engineered (GE) crops can be used as part of a combined strategy to address food insecurity, which is defined as a lack of sustainable access to safe and nutritious food. In this article, we discuss the ...
    • Cloning and functional characterization of the maize carotenoid isomerase and β-carotene hydroxylase genes and their regulation during endosperm maturation 

      Li, Qunrui; Farré Martinez, Gemma; Naqvi, Shaista; Breitenbach, Jürgen; Sanahuja Solsona, Georgina; Bai, Chao; Sandmann, Gerhard; Capell Capell, Teresa; Christou, Paul; Zhu, Changfu (Springer Netherlands, 2010)
      In order to gain further insight into the partly-characterized carotenoid biosynthetic pathway in corn (Zea mays L.), we cloned cDNAs encoding the enzymes carotenoid isomerase (CRTISO) and β-carotene hydroxylase (BCH) using ...
    • Engineering complex metabolic pathways in plants 

      Farré Martinez, Gemma; Capell Capell, Teresa; Zhu, Changfu; Christou, Paul; Blancquaert, Dieter; Van Der Straeten, Dominique (Annual Reviews, 2014)
      Metabolic engineering can be used to modulate endogenous metabolic pathways in plants or introduce new metabolic capabilities in order to increase the production of a desirable compound or reduce the accumulation of ...
    • Engineering metabolic pathways in plants by multigene transformation 

      Zorrilla López, Uxue; Masip Vilà, Gemma; Arjó Pont, Gemma; Bai, Chao; Banakar, Raviraj; Bassie Rene, Ludovic; Berman Quintana, Judit; Farré Martinez, Gemma; Miralpeix i Anglada, Bruna; Pérez Massot, Eduard; Sabalza Gallués, Maite; Sanahuja Solsona, Georgina; Vamvaka, Evangelia; Twyman, Richard M.; Christou, Paul; Zhu, Changfu; Capell Capell, Teresa (University of the Basque Country Press, 2013)
      Metabolic engineering in plants can be used to increase the abundance of specific valuable metabolites, but single-point interventions generally do not improve the yields of target metabolites unless that product is ...
    • Fast quantitative method for the analysis of carotenoids in transgenic maize 

      Rivera Vélez, Sol Maiam; Vilaró, Francisca; Zhu, Changfu; Bai, Chao; Farré Martinez, Gemma; Christou, Paul; Canela i Garayoa, Ramon (American Chemical Society, 2013)
      A fast method was developed to determine carotenoid content in transgenic maize seeds. The analysis was carried out using an ultrahigh-pressure liquid chromatograph coupled to a photodiode array detector and a mass ...
    • High-carotenoid maize: development of plant biotechnology prototypes for human and animal health and nutrition 

      Zhu, Changfu; Farré Martinez, Gemma; Zanga, Daniela; Lloveras Vilamanyà, Jaume; Michelena Bárcena, Antonio; Ferrio Díaz, Juan Pedro; Voltas Velasco, Jordi; Slafer, Gustavo A.; Savin, Roxana; Albajes Garcia, Ramon; Eizaguirre Altuna, Matilde; López Alonso, Carmen; Cantero-Martínez, Carlos; Díaz Gómez, Joana; Nogareda, Carmina; Moreno Martínez, José Antonio; Angulo Asensio, Eduardo; Estany Illa, Joan; Pena i Subirà, Ramona Natacha; Tor i Naudí, Marc; Portero Otín, Manuel; Eritja Sánchez, Núria; Arjó Pont, Gemma; Serrano Casasola, José Carlos Enrique; Matias-Guiu, Xavier; Twyman, Richard M.; Sandmann, Gerhard; Capell Capell, Teresa; Christou, Paul (Springer Verlag, 2017-06-01)
      Carolight® is a transgenic maize variety that accumulates extraordinary levels of carotenoids, including those with vitamin A activity. The development of Carolight® maize involved the technical implementation of a novel ...
    • High-value products from transgenic maize 

      Naqvi, Shaista; Ramessar, Koreen; Farré Martinez, Gemma; Sabalza Gallués, Maite; Miralpeix i Anglada, Bruna; Twyman, Richard M.; Capell Capell, Teresa; Zhu, Changfu; Christou, Paul (Elsevier, 2011)
      Maize (also known as corn) is a domesticated cereal grain that has been grown as food and animal feed for tens of thousands of years. It is currently the most widely grown crop in the world, and is used not only for food/feed ...
    • Identification of line-specific strategies for improving carotenoid production in synthetic maize through data-driven mathematical modeling 

      Comas, Jorge; Benfeitas, Rui; Vilaprinyo Terré, Ester; Sorribas Tello, Albert; Solsona Tehàs, Francesc; Farré Martinez, Gemma; Berman Quintana, Judit; Zorrilla López, Uxue; Capell Capell, Teresa; Sandmann, Gerhard; Zhu, Changfu; Christou, Paul; Alves, Rui (Wiley online library, 2016)
      Plant synthetic biology is still in its infancy. However, synthetic biology approaches have been used to manipulate and improve the nutritional and health value of staple food crops such as rice, potato and maize. With ...
    • Nutritionally enhanced crops and food security: scientific achievements versus political expediency 

      Farré Martinez, Gemma; Twyman, Richard M.; Zhu, Changfu; Capell Capell, Teresa; Christou, Paul (Elsevier, 2011)
      Genetic engineering (GE) is one of a raft of strategies that can be used to tackle malnutrition. Recent scientific advances have shown that multiple deficiencies can be tackled simultaneously using engineered plant varieties ...
    • Nutritious crops producing multiple carotenoids – a metabolic balancing act 

      Farré Martinez, Gemma; Bai, Chao; Twyman, Richard M.; Capell Capell, Teresa; Christou, Paul; Zhu, Changfu (Elsevier, 2011)
      Plants and microbes produce multiple carotenoid pigments with important nutritional roles in animals. By unraveling the basis of carotenoid biosynthesis it has become possible to modulate the key metabolic steps in plants ...
    • Patterns of CRISPR/Cas9 activity in plants, animals and microbes 

      Bortesi, Luisa; Zhu, Changfu; Zischewski, Julia; Pérez Álvarez, Lucía; Bassie Rene, Ludovic; Nadi, Riad; Forni, Giobbe; Lade Lee, Sarah Boyd; Soto, Erika; Jin, Xin; Medina Piles, Vicente; Villorbina Noguera, Gemma; Muñoz Gràcia, Pilar; Farré Martinez, Gemma; Fischer, Rainer; Twyman, Richard M.; Capell Capell, Teresa; Christou, Paul; Schillberg, Stefan (Wiley, 2016)
      The CRISPR/Cas9 system and related RNA-guided endonucleases can introduce double-strand breaks (DSBs) at specific sites in the genome, allowing the generation of targeted mutations in one or more genes as well as more ...
    • Promoter diversity in multigene transformation 

      Peremartí, Ariadna; Twyman, Richard M.; Gómez Galera, Sonia; Naqvi, Shaista; Farré Martinez, Gemma; Sabalza Gallués, Maite; Miralpeix i Anglada, Bruna; Dashevskaya, Svetlana; Yuan, Dawei; Ramessar, Koreen; Christou, Paul; Zhu, Changfu; Bassie Rene, Ludovic; Capell Capell, Teresa (Springer Verlag, 2010)
      Multigene transformation (MGT) is becoming routine in plant biotechnology as researchers seek to generate more complex and ambitious phenotypes in transgenic plants. Every nuclear transgene requires its own promoter, ...
    • Rainfall homogenizes while fruiting increases diversity of spore deposition in Mediterranean conditions 

      Castaño Soler, Carles; Bonet Lledos, José Antonio; Oliva Palau, Jonàs; Farré Martinez, Gemma; Martínez de Aragón, Juan; Parladé Izquierdo, Xavier; Pera i Álvarez, Joan; Alday, Josu G. (ElsevierBritish Mycological Society, 2019-09-01)
      There is a lack of knowledge regarding the main factors modulating fungal spore deposition in forest ecosystems. We have described the local spatio-temporal dynamics of fungal spore deposition along a single fruiting season ...
    • Red Anthocyanins and Yellow Carotenoids Form the Color of Orange-Flower Gentian (Gentiana lutea L. var. aurantiaca) 

      Berman Quintana, Judit; Sheng, Yanmin; Gómez Gómez, Lourdes; Veiga, Tania; Ni, Xiuzhen; Farré Martinez, Gemma; Capell Capell, Teresa; Guitián, Javier; Guitián, Pablo; Sandmann, Gerhard; Christou, Paul; Zhu, Changfu (Public Library of Science, 2016)
      Flower color is an important characteristic that determines the commercial value of ornamental plants. Gentian flowers occur in a limited range of colors because this species is not widely cultivated as a cut flower. ...
    • Simultaneous expression of Arabidopsis ρ-hydroxyphenylpyruvate dioxygenase and MPBQ methyltransferase in transgenic corn kernels triples the tocopherol content 

      Naqvi, Shaista; Farré Martinez, Gemma; Zhu, Changfu; Sandmann, Gerhard; Capell Capell, Teresa; Christou, Paul (Springer Verlag, 2011)
      The quantity and composition of tocopherols (compounds with vitamin E activity) vary widely among different plant species reflecting the expression, activity and substrate specificity of enzymes in the corresponding ...