Now showing items 21-28 of 28

    • Rice endosperm produces an underglycosylated and potent form of the HIV-neutralizing monoclonal antibody 2G12 

      Vamvaka, Evangelia; Twyman, Richard M.; Melro Murad, Andre; Melnik, Stanislav; Yi-Hui Teh, Audrey; Arcalis, Elsa; Altmann, Friedrich; Stöger, Eva; Rech, Elibio; Ma, Julian K-C.; Christou, Paul; Capell Capell, Teresa (Wiley, 2016)
      Protein microbicides against HIV can help to prevent infection but they are required in large, repetitive doses. This makes current fermenter-based production systems prohibitively expensive. Plants are advantageous as ...
    • Strategic patent analysis in plant biotechnology: terpenoid indole alkaloid metabolic engineering as a case study 

      Miralpeix i Anglada, Bruna; Sabalza Gallués, Maite; Twyman, Richard M.; Capell Capell, Teresa; Christou, Paul (John Wiley & Sons Ltd, 2014)
      The do-it-yourself patent search is a useful alternative to professional patent analysis particularly in the context of publicly funded projects where funds for IP activities may be limited. As a case study, we analysed ...
    • The contribution of transgenic plants to better health through improved nutrition: opportunities and constraints 

      Pérez Massot, Eduard; Banakar, Raviraj; Gómez Galera, Sonia; Zorrilla López, Uxue; Sanahuja Solsona, Georgina; Arjó Pont, Gemma; Miralpeix i Anglada, Bruna; Vamvaka, Evangelia; Farré Martinez, Gemma; Rivera Vélez, Sol Maiam; Dashevskaya, Svetlana; Berman Quintana, Judit; Sabalza Gallués, Maite; Yuan, Dawei; Bai, Chao; Bassie Rene, Ludovic; Twyman, Richard M.; Capell Capell, Teresa; Christou, Paul; Zhu, Changfu (Springer Verlag, 2013)
      Malnutrition is a prevalent and entrenched global socioeconomic challenge that reflects the combined impact of poverty, poor access to food, inefficient food distribution infrastructure, and an over-reliance on ...
    • The distribution of carotenoids in hens fed on biofortified maize is influenced by feed composition, absorption, resource allocation and storage 

      Moreno Martínez, José Antonio; Díaz-Gómez, J.; Nogareda, Carmina; Angulo Asensio, Eduardo; Sandmann, Gerhard; Portero Otín, Manuel; Serrano Casasola, José Carlos Enrique; Twyman, Richard M.; Capell Capell, Teresa; Zhu, Changfu; Christou, Paul (Nature, 2016)
      Carotenoids are important dietary nutrients with health-promoting effects. The biofortification of staple foods with carotenoids provides an efficient delivery strategy but little is known about the fate and distribution ...
    • The humanitarian impact of plant biotechnology: recent breakthroughs vs bottlenecks for adoption 

      Farré Martinez, Gemma; Ramessar, Koreen; Twyman, Richard M.; Capell Capell, Teresa; Christou, Paul (Elsevier, 2010)
      The deployment of genetically engineered (GE) crops in developing countries is regarded by some as a sinister manifestation of ‘big business’ in science. What is often overlooked, and sometimes even deliberately ignored ...
    • The potential impact of plant biotechnology on the Millennium Development Goals 

      Yuan, Dawei; Bassie Rene, Ludovic; Sabalza Gallués, Maite; Miralpeix i Anglada, Bruna; Dashevskaya, Svetlana; Farré Martinez, Gemma; Rivera Vélez, Sol Maiam; Banakar, Raviraj; Bai, Chao; Sanahuja Solsona, Georgina; Arjó Pont, Gemma; Avilla, Eva; Zorrilla López, Uxue; Ugidos-Damboriena, Nerea; López, Alberto; Almacellas, David; Zhu, Changfu; Capell Capell, Teresa; Hahne, Gunther; Twyman, Richard M.; Christou, Paul (Springer Verlag, 2011)
      The eight Millennium Development Goals (MDGs) are international development targets for the year 2015 that aim to achieve relative improvements in the standards of health, socioeconomic status and education in the ...
    • Unexpected synergistic HIV neutralization by a triple microbicide produced in rice endosperm 

      Vamvaka, Evangelia; Farré Martinez, Gemma; Molinos-Albert, Luis M.; Evans, Abbey; Canela Xandri, Anna; Twyman, Richard M.; Carrillo, Jorge; Ordóñez, Raziel Antonio; Shattock, Robin J.; O’Keef, Barry R.; Clotet, Bonaventura; Blanco, Julian; Khush, Gurdev S.; Christou, Paul; Capell Capell, Teresa (National Academy of Sciences, 2018-08-14)
      The transmission of HIV can be prevented by the application of neutralizing monoclonal antibodies and lectins. Traditional recombinant protein manufacturing platforms lack sufficient capacity and are too expensive for ...
    • ZmPBF and ZmGAMYB transcription factors independently transactivate the promoter of the maize (Zea mays L.) β-carotene hydroxylase 2 gene 

      Jin, Xin; Bai, Chao; Bassie Rene, Ludovic; Nogareda, Carmina; Romagosa Clariana, Ignacio; Twyman, Richard M.; Christou, Paul; Zhu, Changfu (Wiley, 2018-12-01)
      The maize (Zea mays) enzyme b-carotene hydroxylase 2 (ZmBCH2) controls key steps in the conversion of b-carotene to zeaxanthin in the endosperm. The ZmBCH2 gene has an endosperm-preferred and developmentally regulated ...