Now showing items 21-32 of 32

    • Simultaneous expression of Arabidopsis ρ-hydroxyphenylpyruvate dioxygenase and MPBQ methyltransferase in transgenic corn kernels triples the tocopherol content 

      Naqvi, Shaista; Farré Martinez, Gemma; Zhu, Changfu; Sandmann, Gerhard; Capell Capell, Teresa; Christou, Paul (Springer Verlag, 2011)
      The quantity and composition of tocopherols (compounds with vitamin E activity) vary widely among different plant species reflecting the expression, activity and substrate specificity of enzymes in the corresponding ...
    • Synergistic metabolism in hybrid corn indicates bottlenecks in the carotenoid pathway and leads to the accumulation of extraordinary levels of the nutritionally important carotenoid zeaxanthin 

      Naqvi, Shaista; Zhu, Changfu; Farré Martinez, Gemma; Sandmann, Gerhard; Capell Capell, Teresa; Christou, Paul (Wiley, 2011)
      Lutein and zeaxanthin cannot be synthesized de novo in humans, and althoughlutein is abundant in fruit and vegetables, good dietary sources of zeaxanthin arescarce. Certain corn varieties provide adequate amounts because ...
    • Targeted transcriptomic and metabolic profiling reveals temporal bottlenecks in the maize carotenoid pathway that may be addressed by multigene engineering 

      Farré Martinez, Gemma; Rivera Vélez, Sol Maiam; Alves, Rui; Vilaprinyo Terré, Ester; Sorribas Tello, Albert; Canela i Garayoa, Ramon; Naqvi, Shaista; Sandmann, Gerhard; Capell Capell, Teresa; Zhu, Changfu; Christou, Paul (Wiley, 2013)
      Carotenoids are a diverse group of tetraterpenoid pigments found in plants, fungi, bacteria and some animals. They play vital roles in plants and provide important health benefits to mammals, including humans. We ...
    • The contribution of transgenic plants to better health through improved nutrition: opportunities and constraints 

      Pérez Massot, Eduard; Banakar, Raviraj; Gómez Galera, Sonia; Zorrilla López, Uxue; Sanahuja Solsona, Georgina; Arjó Pont, Gemma; Miralpeix i Anglada, Bruna; Vamvaka, Evangelia; Farré Martinez, Gemma; Rivera Vélez, Sol Maiam; Dashevskaya, Svetlana; Berman Quintana, Judit; Sabalza Gallués, Maite; Yuan, Dawei; Bai, Chao; Bassie Rene, Ludovic; Twyman, Richard M.; Capell Capell, Teresa; Christou, Paul; Zhu, Changfu (Springer Verlag, 2013)
      Malnutrition is a prevalent and entrenched global socioeconomic challenge that reflects the combined impact of poverty, poor access to food, inefficient food distribution infrastructure, and an over-reliance on ...
    • The humanitarian impact of plant biotechnology: recent breakthroughs vs bottlenecks for adoption 

      Farré Martinez, Gemma; Ramessar, Koreen; Twyman, Richard M.; Capell Capell, Teresa; Christou, Paul (Elsevier, 2010)
      The deployment of genetically engineered (GE) crops in developing countries is regarded by some as a sinister manifestation of ‘big business’ in science. What is often overlooked, and sometimes even deliberately ignored ...
    • The potential impact of plant biotechnology on the Millennium Development Goals 

      Yuan, Dawei; Bassie Rene, Ludovic; Sabalza Gallués, Maite; Miralpeix i Anglada, Bruna; Dashevskaya, Svetlana; Farré Martinez, Gemma; Rivera Vélez, Sol Maiam; Banakar, Raviraj; Bai, Chao; Sanahuja Solsona, Georgina; Arjó Pont, Gemma; Avilla, Eva; Zorrilla López, Uxue; Ugidos-Damboriena, Nerea; López, Alberto; Almacellas, David; Zhu, Changfu; Capell Capell, Teresa; Hahne, Gunther; Twyman, Richard M.; Christou, Paul (Springer Verlag, 2011)
      The eight Millennium Development Goals (MDGs) are international development targets for the year 2015 that aim to achieve relative improvements in the standards of health, socioeconomic status and education in the ...
    • The regulation of carotenoid pigmentation in flowers 

      Zhu, Changfu; Bai, Chao; Sanahuja Solsona, Georgina; Yuan, Dawei; Farré Martinez, Gemma; Naqvi, Shaista; Shi, Lianxuan; Capell Capell, Teresa; Christou, Paul (Elsevier, 2010)
      Carotenoids fulfill many processes that are essential for normal growth and development in plants, but they are also responsible for the breathtaking variety of red-to-yellow colors we see in flowers and fruits. Although ...
    • Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways 

      Naqvi, Shaista; Zhu, Changfu; Farré Martinez, Gemma; Ramessar, Koreen; Bassie Rene, Ludovic; Breitenbach, Jürgen; Pérez Conesa, Darío; Ros, Gaspar; Sandmann, Gerhard; Capell Capell, Teresa; Christou, Paul (National Academy of Sciences, 2009)
      Vitamin deficiency affects up to 50% of the world’s population, disproportionately impacting on developing countries where populations endure monotonous, cereal-rich diets. Transgenic plants offer an effective way to ...
    • Transgenic rice grains expressing a heterologous ρ-hydroxyphenylpyruvate dioxygenase shift tocopherol synthesis from the c to the a isoform without increasing absolute tocopherol levels 

      Farré Martinez, Gemma; Sudhakar, Duraialagaraja; Naqvi, Shaista; Sandmann, Gerhard; Christou, Paul; Capell Capell, Teresa; Zhu, Changfu (Springer Verlag, 2012)
      We generated transgenic rice plants overexpressing Arabidopsis thaliana q-hydroxyphenylpyruvate dioxygenase (HPPD), which catalyzes the first committed step in vitamin E biosynthesis. Transgenic grains accumulated ...
    • Travel advice on the road to carotenoids in plants 

      Farré Martinez, Gemma; Sanahuja Solsona, Georgina; Naqvi, Shaista; Bai, Chao; Capell Capell, Teresa; Zhu, Changfu; Christou, Paul (Elsevier, 2010)
      The carotenoids are a major class of organic pigments produced in plants and microbes. They fulfill many essential physiological and developmental processes in plants, and also have important roles in animal health and ...
    • Unexpected synergistic HIV neutralization by a triple microbicide produced in rice endosperm 

      Vamvaka, Evangelia; Farré Martinez, Gemma; Molinos-Albert, Luis M.; Evans, Abbey; Canela Xandri, Anna; Twyman, Richard M.; Carrillo, Jorge; Ordóñez, Raziel Antonio; Shattock, Robin J.; O’Keef, Barry R.; Clotet, Bonaventura; Blanco, Julian; Khush, Gurdev S.; Christou, Paul; Capell Capell, Teresa (National Academy of Sciences, 2018-08-14)
      The transmission of HIV can be prevented by the application of neutralizing monoclonal antibodies and lectins. Traditional recombinant protein manufacturing platforms lack sufficient capacity and are too expensive for ...
    • When more is better: multigene engineering in plants 

      Naqvi, Shaista; Farré Martinez, Gemma; Sanahuja Solsona, Georgina; Capell Capell, Teresa; Zhu, Changfu; Christou, Paul (Elsevier, 2010)
      The genomics revolution has taught us that a great deal of information can be derived from studying many genes or proteins at the same time. We are beginning to see this approach blossoming in applied research. Instead ...