Now showing items 436-455 of 490

    • T-Type Calcium Channels: A Potential Novel Target in Melanoma 

      Barceló Gómez, Carla; Sisó, Pol; Maiques Carlos, Oscar; de la Rosa, Inés; Martí Laborda, Rosa Ma.; Macià Armengol, Anna (MDPI, 2020)
      T-type calcium channels (TTCCs) are overexpressed in several cancers. In this review, we summarize the recent advances and new insights into TTCC biology, tumor progression, and prognosis biomarker and therapeutic potential ...
    • Telomerase activity and telomere length in the colorectal polyp-carcinoma sequence 

      Valls i Bautista, Cristina; Piñol Felis, Carme; Reñé Espinet, Josep Maria; Buenestado Garcia, Juan; Viñas Salas, Joan (Sociedad Española de Patología Digestiva; Arán Ediciones, 2009)
      Objective: the role of telomerase activity and telomere length in the adenoma-carcinoma sequence of colon carcinogenesis has not been well established. The objective of this study was to determine telomerase activity and ...
    • Telomere length is a prognostic factor for overall survival in colorectal cancer 

      Valls i Bautista, Cristina; Piñol Felis, Carme; Reñé Espinet, Josep Maria; Buenestado Garcia, Juan; Viñas Salas, Joan (Wiley, 2011)
      Aim The aim of this study was to determine whether telomere length is an independent prognostic factor for the prevention and survival of colorectal cancer. Method Terminal restriction fragment (TRF) length was determined ...
    • Telomeric repeat factor 1 protein levels correlates with telomere length in colorectal cancer 

      Valls i Bautista, Cristina; Piñol Felis, Carme; Reñé Espinet, Josep Maria; Buenestado Garcia, Juan; Viñas Salas, Joan (Sociedad Española de Patología Digestiva; Arán Ediciones, 2012)
      Background: colorectal cancer is the third cancer cause of death in Spain. It is important to investigate new tumoral markers for early diagnosis, disease monitoring and prevention strategies. Telomeres protect the ...
    • Tenosynovitis with rice body formation presenting as a cutaneous abscess 

      Moreno, Sara; Forcada Calvet, Pau; Soria, Xavier; Altemir, Victoria; Gatius Calderó, Sònia; Gil, Mabel; Matias-Guiu, Xavier; Casanova i Seuma, Josep M. (Josep Manel); Martí Laborda, Rosa Ma. (John Wiley & Sons, 2014)
      A 62-year-old woman with a past medical history of rheumatoid arthritis was referred to the Department of Dermatology because of an enlarging cutaneous lesion on the right thumb which resembled a soft tissue infection. ...
    • TGF-β-Induced transcription sustains amoeboid melanoma migration and dissemination 

      Cantelli, Gaia; Orgaz, Jose L.; Rodríguez Hernández, Irene; Karagiannis, Panagiotis; Maiques Carlos, Oscar; Matias-Guiu, Xavier; Nestle, Frank O.; Martí Laborda, Rosa Ma.; Karagiannis, Sophia N.; Sanz Moreno, Victoria (Elsevier, 2015)
      Cell migration underlies metastatic dissemination of cancer cells, and fast “amoeboid” migration in the invasive fronts of tumors is controlled by high levels of actomyosin contractility. How amoeboid migration is regulated ...
    • The active form of vitamin D, calcitriol, induces a complex dual upregulation of endothelin and nitric oxide in cultured endothelial cells 

      Martínez-Miguel, Patricia; Valdivielso Revilla, José Manuel; Medrano-Andrés, Diana; Román-García, Pablo; Cano-Peñalver, Jose Luis; Rodríguez-Puyol, Manuel; Rodríguez-Puyol, Diego; López-Ongil, Susana (American Physiological Society, 2014)
      Despite the presence of vitamin D receptor (VDR) in endothelial cells, the effect of vitamin D on endothelial function is unknown. An unbalanced production of vasoactive endothelial factors such as nitric oxide (NO) or ...
    • The circadian rest-activity pattern predicts cognitive decline among mild-moderate Alzheimer's disease patients 

      Targa, Adriano; Benítez, Iván; Dakterzada, Farida; Fontenele Araujo, John; Minguez Roure, Olga; Zetterberg, Henrik; Blennow, Kaj; Barbé Illa, Ferran; Piñol Ripoll, Gerard (BMC, 2021)
      Background:Alterations in circadian rhythms are present in the presymptomatic stage of Alzheimer’s disease (AD),possibly contributing to its pathogenesis. However, it is unknown whether such alterations are associated ...
    • The Diagnostic Value of Serum C-Reactive Protein for Identifying Pneumonia in Hospitalized Patients with Acute Respiratory Symptoms 

      Ruiz González, Agustín; Utrillo Montagut, Laia; Bielsa Martín, Silvia; Falguera i Sacrest, Miquel; Porcel Pérez, José Manuel (Hindawi, 2016)
      Background. The clinical diagnosis of pneumonia is sometimes difficult since chest radiographs are often indeterminate. In this study, we aimed to assess whether serum C-reactive protein (CRP) could assist in identifying ...
    • The dipeptide monoester prodrugs of floxuridine and gemcitabine - feasibility of orally administrable nucleoside analogs 

      Tsume, Yasuhiro; Borrás Bermejo, Blanca; Amidon, Gordon L. (MDPI, 2014)
      Dipeptide monoester prodrugs of floxuridine and gemcitabine were synthesized. Their chemical stability in buffers, enzymatic stability in cell homogenates, permeability in mouse intestinal membrane along with drug concentration ...
    • The effect of depressive symptoms on cognition in patients with fibromyalgia 

      Gelonch Rosinach, Olga; Garolera i Freixa, Maite; Valls Marsal, Joan; Castellà, Gerard; Varela, Olalla; Rosselló Aubach, Lluís; Pifarré Paredero, Josep (Public Library of Science, 2018)
      Background Fibromyalgia (FM) patients frequently complain of cognitive problems, but it remains unclear whether these cognitive complaints can be attributed to a dysfunction of the central nervous system or if they can ...
    • The Effect of Enteral Immunonutrition in the Intensive Care Unit: Does It Impact on Outcomes? 

      López Delgado, Juan Carlos; Grau Carmona, Teodoro; Trujillano Cabello, Javier; García Fuentes, Carlos; Mor Marco, Esther; Bordeje Laguna, Mª Luisa; Portugal Rodríguez, Esther; Lorencio Cardenas, Carol; Vera Artazcoz, Paula; Macaya Redin, Laura; Martinez Carmona, Juan Francisco JF,; Mateu Campos, Lidón; Gero Escapa, María; Gastaldo Simeon, Rosa; Vila García, Belén; Flordelis Lasierra, Jose Luis; Montejo González, Juan Carlos; Servià Goixart, Lluís (MDPI, 2022-05-01)
      Background: The present research aimed to evaluate the effect on outcomes of immunonutrition (IMN) enteral formulas during the intensive care unit (ICU) stay. Methods: A multicenter prospective observational study was ...
    • The effect of information about the benefits and harms of mammography on women’s decision-making: study protocol for a randomized controlled trial 

      Misericòrdia, Carles; Martínez Alonso, Montserrat; Pons Rodríguez, Anna; Pérez Lacasta, María José; Perestelo Pérez, Lilisbeth; Sala, Maria; Vidal, Carmen; Garcia, Montse; Toledo Chávarri, Ana; Codern-Bové, Núria; Feijoo Cid, Maria; Romero, Anabel; Pla, Roger; Soler González, Jorge; Castells, Xavier; Rué i Monné, Montserrat (BioMed Central, 2017)
      The decision to participate or not in breast cancer screening is complex due to the trade-off between the expected benefit of breast cancer mortality reduction and the major harm of overdiagnosis. It seems ethically necessary ...
    • The effect on quality of life of vitamin d administration for advanced cancer treatment (vidafact study): Protocol of a randomised controlled trial 

      Martínez Alonso, Montserrat; Ariza Carrió, Gemma; Dusso Rosso, Adriana; Nabal Vicuña, Maria (BMJ Publishing Group, 2015)
      Introduction: Vitamin D is related to resistance to chronic diseases, physiological parameters and functional measures. All of these relationships underscore the potential benefits of cholecalciferol or D3 (nutritional ...
    • The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients 

      Torres, Antoni; Motos, Anna; Riera, Jordi; Fernández Barat, Laia; Ceccato, Adrián; Pérez Arnal, Raquel; García Gasulla, Dario; Peñuelas, Oscar; Lorente, José Ángel; Rodríguez, Alejandro; de Gonzalo Calvo, David; Almansa, Raquel; Gabarrús, Albert; Menéndez, Rosario; Bermejo Martin, Jesús F.; Ferrer, Ricard; Amaya Villar, Rosario; Añón, José M.; Barberà, Carme; Barberán, José; Blandino Ortiz, Aaron; Bustamante Munguira, Elena; Caballero, Jesús; Carbajales, Cristina; Carbonell, Nieves; Catalán González, Mercedes; Galbán, Cristóbal; Gumucio Sanguino, Víctor D.; de la Torre, Maria del Carmen; Díaz, Emili; Estella, Ángel; Gallego, Elena; García Garmendia, José Luis; Garnacho Montero, José; Gómez, José Manuel; Huerta, Arturo; Jorge García, Ruth Noemí; Loza Vázquez, Ana; Marin Corral, Judith; Martínez de la Gándara, Amalia; Martínez Varela, Ignacio; López Messa, Juan; Albaiceta, Guillermo M.; Novo, Mariana Andrea; Peñasco, Yhivian; Pozo Laderas, Juan Carlos; Ricart, Pilar; Salvador Adell, Inmaculada; Sánchez Miralles, Angel; Sancho Chinesta, Susana; Socias, Lorenzo; Solé Violan, Jordi; Suares Sipmann, Fernando; Tamayo Lomas, Luis; Trenado, José; Barbé Illa, Ferran (BMC; International Symposium on Intensive Care and Emergency Medicine (ISICEM); Critical Care Canada Forum (CCCF), 2021)
      Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three ...
    • The H-ATOMIC Criteria for the Etiologic Classification of Patients with Intracerebral Hemorrhage 

      Martí Fàbregas, Joan; Prats Sánchez, Luis; Martínez Domeño, Alejandro; Camps Renom, Pol; Marín, Rebeca; Jiménez Xarrié, Elena; Fuentes, Blanca; Dorado, Laura; Purroy Garcia, Francisco; Arias Rivas, Susana; Delgado Mederos, Raquel (Public Library of Science, 2016)
      Background and Purpose There are no generally accepted criteria for the etiologic classification of intracerebral hemorrhage (ICH). For this reason, we have developed a set of etiologic criteria and have applied them ...
    • The incidence, prevalence, and mortality of stroke in France, Germany, Italy, Spain, the UK, and the US: a literature review 

      Zhang, Younan; Chapman, Ann-Marie; Plested, Melanie; Jackson, Daniel; Purroy Garcia, Francisco (Hindawi Publishing Corporation, 2012)
      Background. Although the burden of stroke in terms of mortality and disability has been well documented in previous years, data after 2000 are limited. Therefore, the aim of this paper was to identify the epidemiology of ...
    • The induction of C/EBPβ contributes to vitamin D inhibition of ADAM17 expression and parathyroid hyperplasia in kidney disease. 

      Arcidiacono, Maria V.; Yang, Jing; Fernández i Giráldez, Elvira; Dusso Rosso, Adriana (Oxford University Press, 2015-03-01)
      Abstract BACKGROUND: In secondary hyperparathyroidism (SHPT), enhanced parathyroid levels of transforming growth factor-α (TGFα) increase EGF receptor (EGFR) activation causing parathyroid hyperplasia, high parathyroid ...
    • The influence of an educational internet-based intervention in the beliefs and attitudes of primary care professionals on non-specific chronic low back pain: study protocol of a mixed methods approach 

      García-Martínez, Ester; Soler González, Jorge; Rubí Carnacea, Francesc; García-Martínez, Beatriz; Climent Sanz, Carolina; Blanco Blanco, Joan; Valenzuela Pascual, Francesc (BMC, 2019)
      Background: Personal convictions in referral to pain cause misbeliefs in health professionals, which can influence patients who suffer from non-specific chronic low back pain. Likewise, health professionals’ beliefs affect ...
    • The influence of cognitive reserve on psychosocial and neuropsychological functioning in bipolar disorder 

      Forcada Pach, Irene; Mur, Maria; Mora Claramunt, Ester; Vieta i Pascual, Eduard, 1963-; Bartrés-Faz, David; Portella, Maria J. (Elsevier, 2015-02)
      Cognitive reserve (CR) refers to the hypothesized capacity of an adult brain to cope with brain pathology in order to minimize symptomatology. CR was initially investigated in dementia and acute brain damage, but it is ...