• Psychometric Properties of the SymptoMScreen Questionnaire in a Mild Disability Population of Patients with Relapsing–Remitting Multiple Sclerosis: Quantifying the Patient’s Perspective 

  Meca-Lallana, José E.; Maurino, Jorge; Hernández Pérez, Miguel A.; Sempere, Ángel P.; Brieva Ruiz, Luis; García-Arcelay, Elena; Terzaghi, María; Saposnik, Gustavo; Ballesteros, Javier (Springer, 2020)

  Crucial elements for achieving optimal long-term outcomes in multiple sclerosis (MS) are patient confidence and effective physician-patient communication. Patient-reported instruments may provide the means to fill the gap ...

• Long-term Effect of CPAP Treatment on Cardiovascular Events in Patients With Resistant Hypertension and Sleep Apnea. Data From the HIPARCO-2 Study 

  Navarro-Soriano, Cristina; Martínez-García, Miguel Angel; Torres, Gerard; Barbé Illa, Ferran; Sánchez de la Torre, Manuel; Caballero-Eraso, Candela; Lloberes, Patricia; Díaz Cambriles, Trinidad; Somoza, María; Masa, Juan F.; González, Mónica; Mañas, Eva; de la Pena, Mónica; García-Río, Francisco; Montserrat, Josep Maria; Muriel, Alfonso; Oscullo, Grace; García-Ortega, Alberto; Posadas, Tomás; Campos-Rodríguez, Francisco; Spanish Sleep Network (Elsevier, 2020)

  Background: There is some controversy about the effect of continuous positive airway pressure (CPAP) on the incidence of cardiovascular events (CVE). However, the incidence of CVE among patients with both obstructive sleep ...

• T-Type Calcium Channels: A Potential Novel Target in Melanoma 

  Barceló Gómez, Carla; Sisó, Pol; Maiques Carlos, Oscar; de la Rosa, Inés; Martí Laborda, Rosa Ma.; Macià Armengol, Anna (MDPI, 2020)

  T-type calcium channels (TTCCs) are overexpressed in several cancers. In this review, we summarize the recent advances and new insights into TTCC biology, tumor progression, and prognosis biomarker and therapeutic potential ...

• Skin Cancer Prevalence in Outdoor Workers of Ski Resorts 

  Gilaberte, Yolanda; Casanova i Seuma, Josep M. (Josep Manel); García-Malinis, Ana Julia; Arias-Santiago, Salvador; García de la Fuente, María Reyes; Pamiés-Gracia, Marta; Ramirez-Palomino, Javier; Ruiz-Campos, Isabel; Gracia-Cazaña, Tamara; Buendia-Eisman, Agustín (Hindawi, 2018)

  Background. Snow reflectivity and altitude increase the exposure of ski resort workers to solar ultraviolet radiation. The aim was to assess the presence of skin cancer in ski resorts workers and compare it with other ...

• Cross-sectional study of the association between empathy and burnout and drug prescribing quality in primary care 

  Yuguero Torres, Oriol; Marsal Mora, Josep Ramon; Esquerda i Aresté, Montse; Galván Santiago, Leonardo; Soler González, Jorge (Cambridge University Press, 2020)

  Objective: The aim of this study was to assess whether burnout and empathy levels among general practitioners (GPs) might influence prescribing performance assessed using pharmaceutical prescription quality standard ...

• Resistant/Refractory Hypertension and Sleep Apnoea: Current Knowledge and Future Challenges 

  Oscullo, Grace; Torres, Gerard; Campos-Rodríguez, Francisco; Posadas, Tomás; Reina-González, Angela; Sapiña-Beltran, Esther; Barbé Illa, Ferran; Martínez-García, Miguel Angel (MDPI, 2019)

  Hypertension is one of the most frequent cardiovascular risk factors. The population of hypertensive patients includes some phenotypes whose blood pressure levels are particularly difficult to control, thus putting them ...

• Protective role of renal proximal tubular alpha-synuclein in the pathogenesis of kidney fibrosis 

  Bozić Stanojević, Milica; Caus, Maite; Rodrigues-Diez, Raul; Pedraza González, Neus; Ruiz-Ortega, Marta; Garí Marsol, Eloi; Gallel Vicente, María del Pilar; Panadés, Maria José; Martinez, Ana; Fernández i Giráldez, Elvira; Valdivielso Revilla, José Manuel (Nature Publishing Group, 2020)

  Kidney fibrosis is a highly deleterious process and a final manifestation of chronic kidney disease. Alpha-(α)-synuclein (SNCA) is an actin-binding neuronal protein with various functions within the brain; however, its ...

• Impact of One-Catheter Strategy with TIG I Catheter on Coronary Catheterization Performance and Economic Costs 

  Costa-Mateu, Joan; Fernández-Rodríguez, Diego; Rivera, Kristian; Casanova, Juan; Irigaray, Patricia; Zielonka, Marta; Pereyra-Acha, Eduardo; Aldomá, Albina; Worner, Fernando (Sociedade Brasileira de Cardiologia, 2019)

  Background: Coronary angiography with two catheters is the traditional strategy for diagnostic coronary procedures. TIG I catheter permits to cannulate both coronary arteries, avoiding exchanging catheters during coronary ...

• Design, optimization and validation of genes commonly used in expression studies on DMH/AOM rat colon carcinogenesis model 

  Bars-Cortina, David; Riera-Escamilla, Antoni; Gou, Gemma; Piñol Felis, Carme; Motilva Casado, Mª José (PeerJ, 2019-01-29)

  Colorectal cancer (CRC), also known as colon cancer, is the third most common form of cancer worldwide in men and the second in women and is characterized by several genetic alterations, among them the expression of several ...

• Sympathetic Hyperactivity and Sleep Disorders in Individuals With Type 2 Diabetes 

  López Cano, Carolina; Gutiérrez Carrasquilla, Liliana; Sánchez Peña, Enric; González, Jessica; Yeramian Hakim, Andree; Martí, Raquel; Hernández García, Marta; Cao, Gonzalo; Ribelles, Mercè; Gómez Arbonés, Javier; Barril, Silvia; Barbé Illa, Ferran; Hernández, Cristina; Simó, Rafael; Lecube Torelló, Albert (Frontiers Medica, 2019)

  Introduction: Many studies on the impact of type 2 diabetes mellitus (T2DM) on sleep breathing have shown a higher prevalence and severity of sleep apnea-hypopnea syndrome (SAHS) in those with T2DM. Moreover, an increased ...

• Depression and Apathy After Transient Ischemic Attack or Minor Stroke: Prevalence, Evolution and Predictors 

  Carnes Vendrell, Anna; Deus Yela, Juan; Molina Seguin, Jessica; Pifarré Paredero, Josep; Purroy Garcia, Francisco (Nature Research, 2019)

  Few previous studies have focused on affective impairment after transient ischemic attack (TIA) and/or minor stroke. The aim was to establish the prevalence, evolution and predictors of post-stroke depression (PSD) and ...

• EV-associated miRNAs from pleural lavage as potential diagnostic biomarkers in lung cancer 

  Roman-Canal, Berta; Moiola, Cristian P.; Gatius Calderó, Sònia; Bonnin, Sarah; Ruiz Miró, Maria; González, Esperanza; Ojanguren, Amaia; Recuero, José Luis; Gil-Moreno, Antonio; Falcón-Pérez, Juan M.; Ponomarenko, Julia; Porcel Pérez, José Manuel; Matias-Guiu, Xavier; Colas, Eva (Nature Research, 2019)

  Lung cancer is the leading cause of cancer-related deaths among men and women in the world, accounting for the 25% of cancer mortality. Early diagnosis is an unmet clinical issue. In this work, we focused to develop a ...

• Genome-Wide Association Study of VKORC1 and CYP2C9 on acenocoumarol dose, stroke recurrence and intracranial haemorrhage in Spain 

  Cullell, Natalia; Carrera, Caty; Muiño, Elena; Torres-Aguila, Nuria-Paz; Cárcel-Márquez, Jara; González-Sánchez, Jonathan; Gallego Fabrega, Cristina; Molina, Jessica; Besora, Sarah; Sotoca, Javier; Buongiorno, Maria-Teresa; Jiménez-Conde, Jordi; Giralt-Steinhauer, Eva; de Torres-Chacón, Reyes; Montaner, Joan; Mancha, Fernando; Cabezas, Juan A.; Martí Fàbregas, Joan; Prats Sánchez, Luis; Camps Renom, Pol; Purroy Garcia, Francisco; Cambray Carner, Serafí; Freijo, María del Mar; Vives-Bauzá, Cristòfol; Tur, Silvia; Font, Maria-Àngels; López-Cancio, Elena; Hernandez-Perez, Maria; Obach, Victor; Calleja, Ana; Arenillas, Juan; Rodríguez-Yáñez, Manuel; Castillo, José; Sobrino, Tomas; Fernández-Cádenas, Israel; Krupinski, Jerzy (Nature Publishing Group, 2020)

  Acenocoumarol is an oral anticoagulant with significant interindividual dose variations. Variants in CYP2C9 and VKORC1 have been associated with acenocoumarol maintenance dose. We analysed whether any of the 49 polymorphisms ...

• Skin Autofluorescence Measurement in Subclinical Atheromatous Disease: Results from the ILERVAS Project 

  Sánchez Peña, Enric; Betriu i Bars, M. Àngels; Yeramian Hakim, Andree; Fernández i Giráldez, Elvira; Purroy Garcia, Francisco; Sánchez de la Torre, Manuel; Pamplona Gras, Reinald; Miquel, Eva; Kerkeni, M.; Hernández, Cristina; Simó, Rafael; Lecube Torelló, Albert (Japan Atherosclerosis Society, 2019)

  AIM: Advanced glycation end-products (AGEs) have been involved in the atherogenic process in the high-risk population. The goal of this study was to demonstrate that AGEs are related to subclinical atheromatous disease in ...

• Assessment of Inner Retinal Layers and Choroidal Thickness in Type 1 Diabetes Mellitus: A Cross-Sectional Study 

  Carbonell, Marc; Alonso, Núria; Castelblanco Echavarría, Esmeralda; Real, Jordi; Ramírez-Morros, Anna; Simó, Rafael; Hernández, Cristina; Jurjo Campo, Carmen; Traveset Maeso, Alicia; Valldeperas, Xavier; Mauricio Puente, Dídac (MDPI, 2019)

  Recent studies have shown that retinal neurodegeneration may precede visible vascular changes in diabetic retinopathy (DR). In addition, the relationship of choroidal thickness (CT) with DR stage is not well defined. To ...

• Obesity, a Diet-Induced Inflammatory Disease 

  Lecube Torelló, Albert; López Cano, Carolina (MDPI, 2019)

• Circulating microRNA profile as a potential biomarker for obstructive sleep apnea diagnosis 

  Santamaria-Martos, Fernando; Benítez, Iván; Ortega Delgado, Francisco José; Zapater, Andrea; Giron, Cristina; Pinilla, Lucía; Pacual, Lydia; Cortijo, Anunciación; Dalmases, Mireia; Fernandez-Real, Jose Manuel; Barbé Illa, Ferran; Sánchez de la Torre, Manuel (Nature Publishing Group, 2019)

  Evaluation of microRNAs (miRNAs) could allow characterization of the obstructive sleep apnea (OSA) and help diagnose it more accurately. We aimed to examine circulating miRNA profiles to establish the differences between ...

• Impairment of Mitochondrial Redox Status in Peripheral Lymphocytes of Multiple Sclerosis Patients 

  Gonzalo Benito, Hugo; Nogueras, L.; Gil-Sánchez, Anna; Vicente Hervás, José; Valcheva, Petya; González Mingot, Cristina; Martin-Gari, Meritxell; Canudes, Marc; Peralta Moncusí, Silvia; Solana Moga, M. José; Pamplona Gras, Reinald; Portero Otín, Manuel; Boada Pallàs, Jordi; Serrano Casasola, José Carlos Enrique; Brieva Ruiz, Luis (Frontiers Media, 2019)

  Literature suggests that oxidative stress (OS) may be involved in the pathogenesis of multiple sclerosis (MS), in which the immune system is known to play a key role. However, to date, the OS in peripheral lymphocytes and ...

• Genetic Testing to Predict Weight Loss and Diabetes Remission and Long-Term Sustainability after Bariatric Surgery: A Pilot Study 

  Ciudin, Andreea; Fidilio, Enzamaria; Ortiz, Angel; Pich, Sara; Salas, Eduardo; Mesa, Jordi; Hernández, Cristina; Simó-Servat, Olga; Lecube Torelló, Albert (2019)

  Introduction: The aim of this pilot study was to assess genetic predisposition risk scores (GPS) in type 2 diabetic and non-diabetic patients in order to predict the better response to bariatric surgery (BS) in terms of ...

• EV-associated miRNAs from peritoneal lavage as potential diagnostic biomarkers in colorectal cancer 

  Roman-Canal, Berta; Tarragona Foradada, Jordi; Moiola, Cristian P.; Gatius Calderó, Sònia; Bonnin, Sarah; Ruiz Miró, Maria; Sierra, José Enrique; Rufas, Maria; González, Esperanza; Porcel Pérez, José Manuel; Gil-Moreno, Antonio; Falcon-Perez, Juan M.; Ponomarenko, Julia; Matias-Guiu, Xavier; Colas, Eva (BioMed Central, 2019)

  Background: Colorectal cancer (CRC) is the third leading cause of cancer-related mortality worldwide. Current systematic methods for diagnosing have inherent limitations so development of a minimally-invasive diagnosis, ...

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