Now showing items 21-40 of 559

    • Prevention of Ventilator-Associated Pneumonia: The Multimodal Approach of the Spanish ICU “Pneumonia Zero” Program 

      Álvarez Lerma, Francisco; Palomar Martínez, Mercedes; Sánchez García, Miguel; Martínez Alonso, Montserrat; Álvarez Rodríguez, Joaquín; Lorente, Leonardo; Arias Rivera, Susana; García, Rosa; Gordo, Federico; Añón, José M.; Jam Gatell, M. Rosa; Vázquez Calatayud, Mónica; Agra varela, Yolanda (Society of Critical Care Medicine; Wolters Kluwer Health, 2018-02)
      Objectives: The “Pneumonia Zero” project is a nationwide multimodal intervention based on the simultaneous implementation of a comprehensive evidence-based bundle measures to prevent ventilator-associated pneumonia in ...
    • Mice harboring the FXN I151F pathological point mutation present decreased frataxin levels, a Friedreich ataxia-like phenotype, and mitochondrial alterations 

      Medina Carbonero, Marta; Sanz Alcázar, Arabela; Britti, Elena; Delaspre, Fabien; Cabiscol Català, Elisa; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (Springer; Birkhäuser Verlag, 2022)
      Friedreich Ataxia (FA) is a rare neuro-cardiodegenerative disease caused by mutations in the frataxin (FXN) gene. The most prevalent mutation is a GAA expansion in the first intron of the gene causing decreased frataxin ...
    • Monitoring anti-PLA2R antibody titres to predict the likelihood of spontaneous remission of membranous nephropathy 

      Jatem Escalante, Elias; Martín Conde, María Luisa; Gracia-Lavedan, Esther; Benítez, Iván; González, Jorge; Colàs Campàs, Laura; Garcia Carrasco, Alicia; Martínez Martínez, Cristina; Segarra Medrano, Alfons (European Renal Association - European Dialysis and Transplant Association (ERA-EDTA); Oxford University Press, 2021)
      Background: In anti-phospholipase A2 receptor (PLA2R) membranous nephropathy (MN) there is controversy whether spontaneous remission (SR) can be predicted using a single titre or by assessing the dynamic changes in anti-PLA2R ...
    • CYP24A1 and KL polymorphisms are associated with the extent of vascular calcification but do not improve prediction of cardiovascular events 

      Solache Berrocal, Guillermo; Rolle Sóñora, Valeria; Martín Fernández, Noelia; Cambray Carner, Serafí; Valdivielso Revilla, José Manuel; Rodríguez, Isabel (Oxford University Press; European Renal Association - European Dialysis and Transplant Association, 2020)
      Background: Novel ways of determining cardiovascular risk are needed as a consequence of population ageing and the increased prevalence of chronic kidney disease (CKD), both of which favour vascular calcification. Since ...
    • Endogenous controls and microRNA profile in female patients with obstructive sleep apnea 

      Zapater, Andrea; Benítez, Iván; Santamaria-Martos, Fernando; Pinilla, Lucía; Targa, Adriano; de Gonzalo Calvo, David; Torres, Gerard; Minguez Roure, Olga; Cortijo, Anunciación; Dalmases, Mireia; Barbé Illa, Ferran; Sánchez de la Torre, Manuel (Nature Research, 2022)
      This work was supported by Instituto de Salud Carlos III (PI14/01266, PI18/00449, PI19/00907, PI20/00577), co-funded by FEDER, “Una manera de hacer europa”, IRBLleida – Fundació Dr. Pifarré, CERCA Programme/Generalitat de ...
    • Views of health professionals on risk-based breast cancer screening and its implementation in the Spanish National Health System: A qualitative discussion group study 

      Laza-Vásquez, Celmira; Codern-Bové, Núria; Cardona, Àngels; Hernández-Leal, María José; Pérez Lacasta, María José; Carles Lavila, Misericordia; Rué i Monné, Montserrat (Public Library of Science, 2022)
      Background: With the aim of increasing benefits and decreasing harms, risk-based breast cancer screening has been proposed as an alternative to age-based screening. This study explores barriers and facilitators to implementing ...
    • ARID1A-deficient cells require HDAC6 for progression of endometrial carcinoma 

      Megino-Luque, Cristina; Sisó, Pol; Mota Martorell, Natàlia; Navaridas Fernández de Bobadilla, Raúl; de la Rosa, Inés; Urdanibia, Izaskun; Albertí Valls, Manel; Santacana Espasa, Maria; Pinyol, Miquel; Bonifaci, Núria; Macià Armengol, Anna; Llobet Navàs, David; Gatius Calderó, Sònia; Matias-Guiu, Xavier; Eritja Sánchez, Núria (Federation of European Biochemical Societies; John Wiley & Sons, 2022)
      AT-rich interactive domain-containing protein 1A (ARID1A) loss-of-function mutation accompanied by a loss of ARID1A protein expression is frequently observed in endometrial carcinomas. However, the molecular mechanisms ...
    • Barriers and facilitators to the implementation of a personalized breast cancer screening program: Views of Spanish health professionals 

      Laza-Vásquez, Celmira; Hernández-Leal, María José; Carles Lavila, Misericordia; Pérez Lacasta, María José; Cruz Esteve, María Inés; Rué i Monné, Montserrat (MDPI, 2022)
      Abstract:This study explored the barriers and facilitators to the implementation of a risk-basedbreast cancer screening program from the point of view of Spanish health professionals. A cross-sectional study with 220 ...
    • Glial cell line-derived neurotrophic factor increases intracellular calcium concentration. Role of calcium/calmodulin in the activation of the phosphatidylinositol 3-kinase pathway 

      Pérez García, María José; Ceña, Valentín; Pablo Llavall, Yolanda de; Llovera i Tomàs, Marta; Comella i Carnicé, Joan Xavier; Soler i Tatché, Rosa Ma. (American Society for Biochemistry and Molecular Biology; Elsevier, 2004)
      Moderate increases of intracellular Ca2+ concentration ([Ca2+]i), induced by either the activation of tropomyosin receptor kinase (Trk) receptors for neurotrophins or by neuronal activity, regulate different intracellular ...
    • Switch from caspase-dependent to caspase-independent death during heart development: essential role of endonuclease G in ischemia-induced DNA processing of differentiated cardiomyocytes 

      Bahi i Pla, Núria; Zhang, Jisheng; Llovera i Tomàs, Marta; Ballester, Manel; Comella i Carnicé, Joan Xavier; Sanchis, Daniel (American Society for Biochemistry and Molecular Biology; Elsevier, 2006)
      Differentiated cardiomyocytes are resistant to caspase-dependent cell death; however, the mechanisms involved are still uncertain. We previously reported that low Apaf1 expression partially accounts for cardiomyocyte ...
    • Impact of time to intubation on mortality and pulmonary sequelae in critically ill patients with COVID-19: a prospective cohort study 

      González, Jessica; Benítez, Iván; de Gonzalo Calvo, David; Torres, Gerard; Batlle Garcia, Jordi de; Gómez Falguera, Silvia; Moncusí Moix, Anna; Carmona, Paola; Santisteve, Sally; Monge Esqué, Aida; Gort Paniello, Clara; Zuil, María; Cabo Gambín, Ramón; Manzano Senra, Carlos; Vengoechea Aragoncillo, José Javier; Vaca, Rafaela; Minguez Roure, Olga; Aguilar, María; Ferrer, Ricard; Ceccato, Adrián; Fernández Barat, Laia; Motos, Anna; Riera, Jordi; Menéndez, Rosario; García Gasulla, Dario; Peñuelas, Oscar; Labarca, Gonzalo; Caballero, Jesús; Barberà, Carme; Torres, Antoni; Barbé Illa, Ferran (BCM, 2022)
      Question: We evaluated whether the time between first respiratory support and intubation of patients receiving invasive mechanical ventilation (IMV) due to COVID-19 was associated with mortality or pulmonary sequelae. Materials ...
    • Differential Immunoexpression of BRAF/V600E, Senescence Markers, PTEN, and T-type Calcium Channels in Acquired Naevi According to their Histopathological and Dermoscopic Classification 

      Moreno, Sara; Maiques Carlos, Oscar; Barceló Gómez, Carla; Romero, Marta; Santacana Espasa, Maria; Gómez, Ignacio; Cuevas Sánchez, Dolors; Velasco Sánchez, Ana; Veà Jódar, Àlvar; Macià Armengol, Anna; Boix, Ramon; Valls Marsal, Joan; Gatius Calderó, Sònia; Cantí Nicolás, Carles; Matias-Guiu, Xavier; Soria, Xavier; Martí Laborda, Rosa Ma. (Society for Publication of Acta Dermato-Venereologica, 2021)
      BRAF/V600E mutation and other cell growth/growth-control mechanisms are involved in naevogenesis and melanomagenesis. Immunoexpression of BRAF/V600E and other molecules (p16, phosphatase and tensin homologue (PTEN), Ki67, ...
    • Both human and soya bean ferritins highly improve the accumulation of bioavailable iron and contribute to extend the chronological life in budding yeast 

      Pujol Carrión, Núria; González-Alfonso, Alma; Puig, Sergi; Torre Ruiz, M. A. de la (Society for Applied Microbiology; John Wiley & Sons Ltd., 2021)
      Ferritin proteins have an enormous capacity to store iron in cells. In search for the best conditions to accumulate and store bioavailable iron, we made use of a double mutant null for the monothiol glutaredoxins GRX3 and ...
    • Calcitriol increases frataxin levels and restores mitochondrial function in cell models of Friedreich Ataxia 

      Britti, Elena; Delaspre, Fabien; Sanz Alcázar, Arabela; Medina Carbonero, Marta; Llovera i Tomàs, Marta; Purroy Lledós, Rosa; Mincheva Tasheva, Stefka; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim (Portland Press; Biochemical Society, 2021)
      Friedreich Ataxia (FA) is a neurodegenerative disease caused by the deficiency of frataxin, a mitochondrial protein. In primary cultures of dorsl root ganglia neurons, we showed that frataxin depletion resulted in decreased ...
    • Machine learning analysis of serum biomarkers for cardiovascular risk assessment in chronic kidney disease 

      Forné Izquierdo, Carles; Cambray Carner, Serafí; Bermúdez López, Marcelino; Fernández i Giráldez, Elvira; Bozić Stanojević, Milica; Valdivielso Revilla, José Manuel (Oxford University Press, 2019)
      Background. Chronic kidney disease (CKD) patients show an increased burden of atherosclerosis and high risk of cardiovascular events (CVEs). There are several biomarkers described as being associated with CVEs, but their ...
    • Clinical and Epidemiological Characteristics of Streptococcus suis Infections in Catalonia, Spain 

      Díez de los Ríos, Javier; Reynaga, Esteban; Garcia Gonzalez, Mercedes; Càmara, Jordi; Ardanuy, Carmen; Cuquet, Jordi; Quesada, Maria D.; Navarro, Marian; Vilamala, Anna; Párraga Niño, Noemi; Quero, Sara; Romero, Alba; Benítez, Rosa M.; Altimiras, Jacint; Pedro Botet, Maria Luisa (Frontiers Media, 2021)
      Introduction: Streptococcus suis (S. suis) is a human zoonotic pathogen of occupational origin, with infection acquired through contact with live pigs or pig meat. Pig farming is one of Catalonia's biggest industries and ...
    • Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation 

      Guerrero-Gómez, David; Mora-Lorca, José Antonio; Sáenz-Narciso, Beatriz; Naranjo-Galindo, Francisco José; Muñoz-Lobato, Fernando; Parrado-Fernández, Cristina; Goikolea, Julen; Cedazo-Minguez, Ángel; Link, Christopher D.; Neri, Christian; Sequedo, María Dolores; Vázquez-Manrique, Rafael P.; Fernández-Suárez, Elena; Goder, Veit; Pane Domenec, Roser; Cabiscol Català, Elisa; Askjaer, Peter; Cabello, Juan; Miranda-Vizuete, Antonio (Springer Nature, 2019)
      In the presence of aggregation-prone proteins, the cytosol and endoplasmic reticulum (ER) undergo a dramatic shift in their respective redox status, with the cytosol becoming more oxidized and the ER more reducing. However, ...
    • Revisiting Trade-offs between Rubisco Kinetic Parameter 

      Flamholz, Avi I.; Prywes, Noam; Moran, Uri; Davidi, Dan; Bar-On, Yinon M.; Oltrogge, Luke M.; Alves, Rui; Savage, David; Milo, Ron (American Chemical Society, 2019)
      Rubisco is the primary carboxylase of the Calvin cycle, the most abundant enzyme in the biosphere, and one of the best-characterized enzymes. On the basis of correlations between Rubisco kinetic parameters, it is widely ...
    • Plasma profiling reveals a blood-based metabolic fingerprint of obstructive sleep apnea 

      Pinilla, Lucía; Benítez, Iván; Santamaría Martos, Fernando; Targa, Adriano; Moncusí Moix, Anna; Dalmases, Mireia; Minguez Roure, Olga; Aguilà, Maria; Jové Font, Mariona; Sol, Joaquim; Pamplona Gras, Reinald; Barbé Illa, Ferran; Sánchez de la Torre, Manuel (Elsevier, 2022)
      Introduction: Obstructive sleep apnea (OSA) is a chronic, heterogeneous and multicomponent disorder with associated cardiovascular and metabolic alterations. Despite being the most common sleep-disordered breathing, it ...
    • Cardiac fibroblasts display endurance to ischemia, high ROS control and elevated respiration regulated by the JAK2/STAT pathway 

      Beà Tàrrega, Aida; García Valero, Juan; Irazoki, Andrea; Lana, Carlos; López-Lluch, Guillermo; Portero Otín, Manuel; Pérez Galán, Patricia; Inserte Igual, Javier; Ruiz Meana, Marisol; Zorzano, Antonio; Llovera i Tomàs, Marta; Sanchis, Daniel (John Wiley & Sons, 2021)
      Cardiovascular diseases are the leading cause of death globally and more than four out of five cases are due to ischemic events. Cardiac fibroblasts (CF) contribute to normal heart development and function, and produce the ...