Articles publicats (Ciències Mèdiques Bàsiques): Recent submissions
Now showing items 1-20 of 550
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T-type channels in cancer cells: Driving in reverse
(Elsevier, 2022-06-06)In the strongly polarized membranes of excitable cells, activation of T-type Ca2+ channels (TTCCs) by weak depolarizing stimuli allows the influx of Ca2+ which further amplifies membrane depolarization, thus 'recruiting' ... -
Avances hacia el cribado personalizado del cáncer de mama: el papel de la Atención Primaria
(Elsevier, 2022)El cáncer de mama es la primera causa de muerte en el mundo entre las mujeres. El Sistema Nacional de Salud (SNS) introdujo el cribado poblacional de cáncer de mama en 1990. Como en la mayoría de los programas europeos, ... -
Factors associated with higher rate of Complete Pathologic Response after Long-Course Neoadjuvant Treatment for Locally Advanced Rectal Cancer Patients – Results from a retrospective cohort study focused on Inflammatory Indexes
(Shiraz University of Medical Sciences, 2021)BACKGROUND: Pathologic complete response (pCR) after neoadjuvant chemoradiotherapy (NCRT) has a prognostic value in locally advanced rectal cancer (LARC). This study aimed to evaluate the ability to predict pCR using ... -
Magnesium Levels Modify the Effect of Lipid Parameters on Carotid Intima Media Thickness
(MDPI, 2020)Classical risk factors of atherosclerosis in the general population show paradoxical effects in chronic kidney disease (CKD) patients. Thus, low low-density lipoprotein (LDL) cholesterol levels have been associated with ... -
Development and validation of a sample entropy-based method to identify complex patient-ventilator interactions during mechanical ventilation
(Scientific Reports, 2020)Patient-ventilator asynchronies can be detected by close monitoring of ventilator screens by clinicians or through automated algorithms. However, detecting complex patient-ventilator interactions (CP-VI), consisting of ... -
Adaptation to Varying Salinity in Halomonas elongata: Much More Than Ectoine Accumulation
(Frontiers Media, 2022)The halophilic γ-proteobacterium Halomonas elongata DSM 2581 T thrives at salt concentrations well above 10 % NaCl (1.7 M NaCl). A well-known osmoregulatory mechanism is the accumulation of the compatible solute ectoine ... -
Intratumor genetic heterogeneity and clonal evolution to decode endometrial cancer progression
(Springer Nature, 2022)Analyzing different tumor regions by next generation sequencing allows the assessment of intratumor genetic heterogeneity (ITGH), a phenomenon that has been studied widely in some tumor types but has been less well explored ... -
Cognitive phenotypes 1 month after ICU discharge in mechanically ventilated patients: a prospective observational cohort study
(BioMed Central; Springer Nature, 2020)Background ICU patients undergoing invasive mechanical ventilation experience cognitive decline associated with their critical illness and its management. The early detection of different cognitive phenotypes might reveal ... -
Tau inhibits mitochondrial calcium efflux and makes neurons vulnerable to calciuminduced cell death
(Elsevier, 2020-03)Aggregation or phosphorylation of the microtubule-associated protein tau is the pathological hallmark in a number of diseases termed tauopathies, which include the most common neurodegenerative disorder, Alzheimer’s disease; ... -
Tetralol derivative NNC-55-0396 induces glioblastoma cell death by activating IRE1α, JNK1 and calcium signaling
(Elsevier, 2022-04-04)Mibefradil and NNC-55-0396, tetralol derivatives with a proven ability to block T-type calcium channels in excitable cells, reduce cancer cell viability in vitro, causing cell death. Furthermore, they reduce tumor growth ... -
Multilevel interactions between native and ectopic isoprenoid pathways affect global metabolism in rice
(Springer, 2022)MVA pathway could be circumvented by express- ing an ectopic plastidial MVA pathway that increases the accumulation of IPP and DMAPP in plastids. We therefore introduced genes encoding the plastid- targeted enzymes ... -
Prevention of Ventilator-Associated Pneumonia: The Multimodal Approach of the Spanish ICU “Pneumonia Zero” Program
(Society of Critical Care Medicine; Wolters Kluwer Health, 2018-02)Objectives: The “Pneumonia Zero” project is a nationwide multimodal intervention based on the simultaneous implementation of a comprehensive evidence-based bundle measures to prevent ventilator-associated pneumonia in ... -
Mice harboring the FXN I151F pathological point mutation present decreased frataxin levels, a Friedreich ataxia-like phenotype, and mitochondrial alterations
(Springer; Birkhäuser Verlag, 2022)Friedreich Ataxia (FA) is a rare neuro-cardiodegenerative disease caused by mutations in the frataxin (FXN) gene. The most prevalent mutation is a GAA expansion in the first intron of the gene causing decreased frataxin ... -
Monitoring anti-PLA2R antibody titres to predict the likelihood of spontaneous remission of membranous nephropathy
(European Renal Association - European Dialysis and Transplant Association (ERA-EDTA); Oxford University Press, 2021)Background: In anti-phospholipase A2 receptor (PLA2R) membranous nephropathy (MN) there is controversy whether spontaneous remission (SR) can be predicted using a single titre or by assessing the dynamic changes in anti-PLA2R ... -
CYP24A1 and KL polymorphisms are associated with the extent of vascular calcification but do not improve prediction of cardiovascular events
(Oxford University Press; European Renal Association - European Dialysis and Transplant Association, 2020)Background: Novel ways of determining cardiovascular risk are needed as a consequence of population ageing and the increased prevalence of chronic kidney disease (CKD), both of which favour vascular calcification. Since ... -
Endogenous controls and microRNA profile in female patients with obstructive sleep apnea
(Nature Research, 2022)This work was supported by Instituto de Salud Carlos III (PI14/01266, PI18/00449, PI19/00907, PI20/00577), co-funded by FEDER, “Una manera de hacer europa”, IRBLleida – Fundació Dr. Pifarré, CERCA Programme/Generalitat de ... -
Views of health professionals on risk-based breast cancer screening and its implementation in the Spanish National Health System: A qualitative discussion group study
(Public Library of Science, 2022)Background: With the aim of increasing benefits and decreasing harms, risk-based breast cancer screening has been proposed as an alternative to age-based screening. This study explores barriers and facilitators to implementing ... -
ARID1A-deficient cells require HDAC6 for progression of endometrial carcinoma
(Federation of European Biochemical Societies; John Wiley & Sons, 2022)AT-rich interactive domain-containing protein 1A (ARID1A) loss-of-function mutation accompanied by a loss of ARID1A protein expression is frequently observed in endometrial carcinomas. However, the molecular mechanisms ... -
Barriers and facilitators to the implementation of a personalized breast cancer screening program: Views of Spanish health professionals
(MDPI, 2022)Abstract:This study explored the barriers and facilitators to the implementation of a risk-basedbreast cancer screening program from the point of view of Spanish health professionals. A cross-sectional study with 220 ... -
Glial cell line-derived neurotrophic factor increases intracellular calcium concentration. Role of calcium/calmodulin in the activation of the phosphatidylinositol 3-kinase pathway
(American Society for Biochemistry and Molecular Biology; Elsevier, 2004)Moderate increases of intracellular Ca2+ concentration ([Ca2+]i), induced by either the activation of tropomyosin receptor kinase (Trk) receptors for neurotrophins or by neuronal activity, regulate different intracellular ...