Now showing items 1-4 of 4

    • HGF regulates the development of cortical pyramidal dendrites 

      Gutierrez, Humberto; Dolcet Roca, Xavier; Tolcos, Mary; Davies, Alun M. (Company of Biologists Ltd., 2004-08)
      Although hepatocyte growth factor (HGF) and its receptor tyrosine kinase MET are widely expressed in the developing and mature central nervous system, little is known about the role of MET signaling in the brain. We have ...
    • Neuronal survival induced by neurotrophins requires calmodulin 

      Egea Navarro, Joaquim; Espinet Mestre, Carme; Soler i Tatché, Rosa Ma.; Dolcet Roca, Xavier; Yuste Mateos, Víctor J. (Víctor José); Encinas Martín, Mario; Iglesias Durán, Montserrat; Rocamora Ibars, Nativitat; Comella i Carnicé, Joan Xavier (Rockefeller University Press, 2001)
      It has been reported that phosphoinositide 3-kinase (PI 3-kinase) and its downstream target, protein kinase B (PKB), play a central role in the signaling of cell survival triggered by neurotrophins (NTs). In this report, ...
    • Presenilin/g-secretase-dependent EphA3 processing mediates axon elongation through non-muscle myosin IIA 

      Javier-Torrent, Míriam; Marco, Sergio; Rocandio, Daniel; Pons-Vizcarra, Maria; Janes, Peter W; Lackmann, Martin; Egea Navarro, Joaquim; Saura, Carlos A (eLife Sciences Publications, 2019)
      EphA/ephrin signaling regulates axon growth and guidance of neurons, but whether this process occurs also independently of ephrins is unclear. We show that presenilin-1 (PS1)/γ-secretase is required for axon growth in the ...
    • Relevance of death receptors in nervous system: role in the pathogenesis of neurodegenerative diseases and targets for therapy 

      Segura Ginard, Miguel Francisco; Comella i Carnicé, Joan Xavier (Institut d'Estudis Catalans. Secció de Ciències i Tecnologia, 2008)
      L’apoptosi és un procés fisiològic que controla el nombre de cèl·lules en organismes superiors. L’apoptosi està estrictament regulada i s’ha vist que està implicada en la patogènesi d’algunes malalties del sistema nerviós. ...