Now showing items 1-3 of 3

    • Protein oxidation in Huntington disease affects energy production and vitamin B6 metabolism 

      Sorolla Bardají, Maria Alba; Rodríguez Colman, Maria José; Tamarit Sumalla, Jordi; Ortega, Zaira; Lucas, José J.; Ferrer, Isidre; Ros Salvador, Joaquim; Cabiscol Català, Elisa (Elsevier, 2010)
      Huntington disease (HD) is an inherited neurodegenerative disorder that initially affects the striatum and progressively the cortex. Oxidative stress in HD has been described as important to disease progression. In ...
    • Proteomic and oxidative stress analysis in human brain samples of Huntington disease 

      Sorolla Bardají, Maria Alba; Reverter Branchat, Gemma; Tamarit Sumalla, Jordi; Ferrer, Isidre; Ros Salvador, Joaquim; Cabiscol Català, Elisa (Elsevier, 2008)
      Huntington disease (HD) is a neurodegenerative disorder caused by expansion of CAG repeats in exon 1 of the huntingtin gene, affecting initially the striatum and progressively the cortex. This work reports a proteomic analysis ...
    • Sir2 is induced by oxidative stress in a yeast model of Huntington disease and its activation reduces protein aggregation 

      Sorolla Bardají, Maria Alba; Nierga, Clara; Rodríguez Colman, Maria José; Reverter Branchat, Gemma; Arenas, Alicia; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim; Cabiscol Català, Elisa (Elsevier, 2011)
      Huntington disease (HD) is a neurodegenerative disorder caused by expansion of CAG trinucleotide repeats, leading to an elongated polyglutamine sequence (polyQ) in the huntingtin protein. Misfolding of mutant polyQ ...