Browsing Articles publicats (Ciències Mèdiques Bàsiques) by Issue Date
Now showing items 1-20 of 523
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Insertion of a malE B-Galactosidase fusion protein into the envelope of Escherichia coli disrupts biogenesis of outer membrane proteins and processing of inner membrane proteins
(American Society for Microbiology, 1982)The synthesis of a membrane-bound MalE ,B-galactosidase hybrid protein, when induced by growth of Escherichia coli on maltose, leads to inhibition of cell division and eventually a reduced rate of mass increase. In ... -
Anys potencials de vida perduts: comparació de tres mètodes de càlcul
(Ajuntament de Barcelona. Àrea de Sanitat, Salut Pública i Medi Ambient, 1991)En l’estudi es comparen dos mètodes de càlcul dels Anys Potencials de Vida Perduts (de 0 a 65 anys i d'1 a 70 anys) amb un tercer (de 0 anys a Ev), considerat a priori el més adequat; al mateix temps es vol corroborar que ... -
Isolation and characterization of Saccharomyces cerevisiae mutants resistant to aculeacin A
(American Society for Microbiology, 1991)Aculeacin A is a lipopeptide that inhibits ,B-glucan synthesis in yeasts. A number of Saccharomyces cerevisiae mutants resistant to this antibiotic were isolated, and four loci (ACRI, ACR2, ACR3, and ACR4) whose products ... -
Creixement tumoral i metabolisme de l'hoste: dues cares d'una mateixa moneda
(Institut d'Estudis Catalans, 1993)L'etiologia del càncer es basa fonamentalment en l'aparició d'un dany genètic en una cèl·lula que ocasiona una expressió anormal de determinats gens, els productes dels quals canvien dramàticament el fenotip cel·lular. Com ... -
Tumour necrosis factor-alpha increases the ubiquitinization of rat skeletal muscle proteins.
(Wiley, 1993)An acute intravenous administration of 100 micrograms/kg body weight of recombinant tumour necrosis factor-alpha (TNF) resulted in a time-dependent increase in the levels of both free and conjugated ubiquitin in rat skeletal ... -
Metal-catalyzed Oxidation of Fe2+ Dehydrogenases: consensus target sequence between Propanediol Oxidoreductase of Escherichia Coli and alcohol dehydrogenase I1 of Zymomonas Mobilis
(American Society for Biochemistry and Molecular Biology, 1994)We have studied two enzymes of a newly described family of dehydrogenases with high sequence homology, 1,2-propanediol oxidoreductase of Escherichia coli and alcohol dehydrogenase II of Zymomonas mobilis. These enzymes ... -
Ubiquitin gene expression is increased in skeletal muscle of tumour-bearing rats
(Elsevier, 1994)Rats bearing the fast-growing AH-130 Yoshida ascites hepatoma showed a marked cachectic response which has been previously reported [Tessitore et al. (1987) Biochem. J. 241, 153-159]. Thus tumour-bearing animals showed ... -
Carbonic Anhydrase III. Oxidative modification in vivo and loss of phosphatase activity during aging
(American Society for Biochemistry and Molecular Biology, 1995)Oxidative modification of DNA, lipids, and proteins occurs as a consequence of reaction with free radicals and activated oxygen. Oxidative modification of total cellular proteins has been described under many pathologic ... -
Ubiquitin gene expression in skeletal muscle is increased during sepsis: involvement of TNF-alpha but not IL-1
(Elsevier, 1995)Septic rats showed an enhanced expression in skeletal muscle of both 1.2 (500%) and 2.4 (530%) kb mRNAs for the peptide ubiquitin, which reflects the activity of the ATP-ubiquitin-dependent proteolytic system. An acute ... -
Spinal Anesthesia with Bupivacaine and Fentanyl in Geriatric Patients
(Lippincott, Williams & Wilkins, 1996)We assessed the risks and benefits of the administration of fentanyl during spinal anesthesia in the elderly. Forty patients (70-83 yr) undergoing knee or hip replacement were studied. Preoperatively, cognitive function ... -
Factors predicting failure of endoscopic injection therapy in bleeding duodenal ulcer
(Elsevier, 1996)Background: The aim of this study was to assess the factors that may cause failure of endoscopic injection in patients bleeding from a duodenal ulcer. Methods: One hundred twenty patients admitted for a bleeding duodenal ... -
Lung cancer mortality among males of Catalonia and Spain compared with other European countries between 1975-1977 and 1987-1989
(Wiley, 1996)This study compares the lung cancer mortality rates among males in the years 1975- I977 and 1987- I989 in Catalonia and Spain with other European countries selected for their geographical proximity. Adjusted calculations ... -
Comparison of cytospat and pipelle endometrial biopsy instruments
(Elsevier, 1997)OBJECTIVE: To compare two endometrial biopsy techniques, based on the quality of material obtained, cost effectiveness, and pain during the procedure. STUDY DESIGN: A single blind, randomized prospective study. RESULTS: A ... -
Comparative effects of beta2-adrenergic agonists on muscle waste associated with tumour growth.
(Elsevier, 1997)The implantation of the Yoshida AH- 130 ascites hepatoma (a fast growing tumour) to rats resulted in a drarnatic loss of both white adipose tissue and muscle (skeletal and cardiac) mass. Administration of &adrenergic ... -
Differential Inactivation of Alcohol Dehydrogenase Isoenzymes in Zymomonas mobilis by Oxygen
(American Society for Microbiology, 1997)Zymomonas mobilis is endowed with two isoenzymes of fermentative alcohol dehydrogenase, a zinc-containing enzyme (ADH I) and an iron-containing enzyme (ADH II). The activity of ADH I remains fully conserved, while ADH ... -
Evolution of an Escherichia coli Protein with Increased Resistance to Oxidative Stress
(American Society for Biochemistry and Molecular Biology, 1998)L-1,2-Propanediol:NAD1 1-oxidoreductase of Escherichia coli is encoded by the fucO gene, a member of the regulon specifying dissimilation of L-fucose. The enzyme normally functions during fermentative growth to ... -
An activator/repressor dual system allows tight tetracycline-regulated gene expression in budding yeast
(Oxford University Press, 1998)We have developed an activator/repressor expression system for budding yeast in which tetracyclines control in opposite ways the ability of tetR-based activator and repressor molecules to bind tetO promoters. This combination ... -
Identification of the Major Oxidatively Damaged Proteins in Escherichia coli Cells Exposed to Oxidative Stress
(American Society for Biochemistry and Molecular Biology, 1998)In the present study we have analyzed protein oxidation on Escherichia coli when these cells were submitted to different stress conditions such as hydrogen peroxide, superoxide-generating compounds, and iron ... -
Serum Deprivation and Protein Synthesis Inhibition Induce Two Different Apoptotic Processes in N18 Neuroblastoma Cells
(Elsevier, 1998)N18 are murine neuroblastoma cells that underwent cell death upon serum deprivation or inhibition of protein synthesis by means of cycloheximide (CHX). In both cases, an ultrastructural morphology and an internucleosomal ... -
Calmodulin Modulates Mitogen-Activated Protein Kinase Activation in Response to Membrane Depolarization in PC12 Cells
(Wiley, 1998)In the absence of neurotrophic factors, chronic depolarization of plasma membrane has been shown to maintain several populations of primary neurons in culture. We report that in the PC12 cell line, depolarization causes ...