Now showing items 1-11 of 11

    • 2-phenylethynesulphonamide (PFT-μ) enhances the anticancer effect of the novel hsp90 inhibitor NVP-AUY922 in melanoma, by reducing GSH levels 

      Yeramian Hakim, Andree; Veà Jódar, Àlvar; Benítez, Sandra; Ribera i Calvet, Joan; Domingo, Mónica; Santacana Espasa, Maria; Martínez Alonso, Montserrat; Maiques Carlos, Oscar; Valls Marsal, Joan; Dolcet Roca, Xavier; Vilella, Ramón; Cabiscol Català, Elisa; Matias-Guiu, Xavier; Marti, Rosa M. (Wiley online library, 2016)
      Heat shock proteins (HSPs), are molecular chaperones that assist the proper folding of nascent proteins. This study aims to evaluate the antitumour effects of the hsp90 inhibitor NVP-AUY922 in melanoma, both in vitro ...
    • A Smad3-PTEN regulatory loop controls proliferation and apoptotic responses to TGF-β in mouse endometrium 

      Eritja Sánchez, Núria; Felip, Isidre; Dosil Garcia, Maria Alba; Vigezzi, Lucia; Mirantes Barbeito, Cristina; Yeramian Hakim, Andree; Navaridas Fernández de Bobadilla, Raúl; Santacana Espasa, Maria; Llobet Navàs, David; Yoshimura, Akihiko; Nomura, Masatoshi; Encinas Martín, Mario; Matias-Guiu, Xavier; Dolcet Roca, Xavier (Nature Publishing Group, 2017-05-19)
      The TGF-β/Smad and the PI3K/AKT signaling pathways are important regulators of proliferation and apoptosis, and their alterations lead to cancer development. TGF-β acts as a tumor suppressor in premalignant cells, but it ...
    • Antioxidants impair anti-tumoral effects of Vorinostat, but not anti-neoplastic effects of Vorinostat and caspase-8 downregulation 

      Bergadà Bertran, Laura; Yeramian Hakim, Andree; Sorolla Bardají, Anabel; Matias-Guiu, Xavier; Dolcet Roca, Xavier (Public Library of Science, 2014)
      We have recently demonstrated that histone deacetylase inhibitor, Vorinostat, applied as a single therapy or in combination with caspase-8 downregulation exhibits high anti-tumoral activity on endometrial carcinoma cell ...
    • Autophagy orchestrates adaptive responses to targeted therapy in endometrial cancer 

      Eritja Sánchez, Núria; Chen, Bo-Juen; Rodríguez Barrueco, Ruth; Santacana Espasa, Maria; Gatius Calderó, Sònia; Vidal, August; Martí, Maria Dolores; Ponce, Jordi; Bergadà Bertran, Laura; Yeramian Hakim, Andree; Encinas Martín, Mario; Ribera i Calvet, Joan; Reventós, Jaume; Boyd, Jeff; Villanueva, Alberto; Matias-Guiu, Xavier; Dolcet Roca, Xavier; Llobet Navàs, David (Taylor & Francis, 2017)
      Targeted therapies in endometrial cancer (EC) using kinase inhibitors rarely result in complete tumor remission and are frequently challenged by the appearance of refractory cell clones, eventually resulting in disease ...
    • Combination of Vorinostat and caspase-8 inhibition exhibitshigh anti-tumoral activity on endometrial cancer cells 

      Eritja Sánchez, Núria; Bergadà Bertran, Laura; Sorolla Bardají, Anabel; Yeramian Hakim, Andree; Mirantes, Cristina; Matias-Guiu, Xavier; Dolcet Roca, Xavier (Elsevier, 2013)
      Histone deacetylase inhibitors such as Vorinostat display anti-neoplastic activity against avariety of solid tumors. Here, we have investigated the anti-tumoral activity of Vorinostaton endometrial cancer cells. We have ...
    • Expression of somatostatin receptors in human melanoma cell lines: effect of two different somatostatin analogues, octreotide and SOM230, on cell proliferation 

      Martínez Alonso, Montserrat; Llecha Cano, Núria; Mayorga Mayorga, Maritza Elfride; Sorolla Bardají, Anabel; Dolcet Roca, Xavier; Sanmartín Novell, Verònica; Abal Diaz, Leandro; Casanova i Seuma, Josep M. (Josep Manel); Baradad Brusau, Manuel; Yeramian Hakim, Andree; Egido Garcia, Ramon Maria; Puig, Susana; Vilella, Ramón; Matias-Guiu, Xavier; Martí Laborda, Rosa Ma. (Field House Publishing, 2009)
      Somatostatin analogues (SAs) are potential anticancer agents. This study was designed to investigate the expression of somatostatin receptors (SSTRs) in melanoma cells and the effect of two SAs on cell proliferation and ...
    • Hypoxia-independent gene expression signature associated with radiosensitisation of prostate cancer cell lines by histone deacetylase inhibition 

      Jonsson, Marte; Ragnum, Harald Bull; Julin, Cathinka Halle; Yeramian Hakim, Andree; Clancy, Trevor; Frikstad, Kari-Anne Myrum; Seierstad, Therese; Stokke, Trond; Matias-Guiu, Xavier; Ree, Anne Hansen; Flatmark, Kjersti; Lyng, Heidi (Nature Publishing Group, 2016-10-11)
      Background: Histone deacetylase inhibitors (HDACis) like vorinostat are promising radiosensitisers in prostate cancer, but their effect under hypoxia is not known. We investigated gene expression associated with ...
    • Inhibition of WNT-CTNNB1 signaling upregulates SQSTM1 and sensitizes glioblastoma cells to autophagy blockers 

      Nàger Grifo, Mireia; Crespí Sallán, Marta; Visa Pretel, Anna; Pushparaj, Charumathi; Santacana Espasa, Maria; Macià Armengol, Anna; Yeramian Hakim, Andree; Cantí Nicolás, Carles; Herreros Danés, Judit (Taylor & Francis, 2018-01-09)
      WNT-CTNN1B signaling promotes cancer cell proliferation and stemness. Furthermore, recent evidence indicates that macroautophagy/autophagy regulates WNT signaling. Here we investigated the impact of inhibiting WNT signaling ...
    • Metabotyping human endometrioid endometrial adenocarcinoma reveals an implication of endocannabinoid metabolism 

      Jové Font, Mariona; Gatius Calderó, Sònia; Yeramian Hakim, Andree; Portero Otín, Manuel; Eritja Sánchez, Núria; Santacana Espasa, Maria; Colás, Eva; Ruiz, M.; Pamplona Gras, Reinald; Matias-Guiu, Xavier (Impact Journals, 2016)
      Metabolomics, an essential technique in precision medicine, contributes to the molecular fingerprinting of tumours, further helping to understand their pathogenesis. In this work, using a LC-ESI-QTOF-MS/MS platform, we ...
    • Signalling by neurotrophins and hepatocyte growth factor regulates axon morphogenesis by differential β-catenin phosphorylation 

      David, Mónica Delia; Yeramian Hakim, Andree; Duñach, Mireia; Llovera i Tomàs, Marta; Cantí Nicolás, Carles; Garcia de Herreros, Antonio; Comella i Carnicé, Joan Xavier; Herreros Danés, Judit (Company of Biologist, 2008)
      Tyrosine phosphorylation of ß-catenin, a component of adhesion complexes and the Wnt pathway, affects cell adhesion, migration and gene transcription. By reducing ßcatenin availability using shRNA-mediated gene silencing ...
    • Skin Autofluorescence Measurement in Subclinical Atheromatous Disease: Results from the ILERVAS Project 

      Sánchez Peña, Enric; Betriu i Bars, M. Àngels; Yeramian Hakim, Andree; Fernández i Giráldez, Elvira; Purroy Garcia, Francisco; Sánchez de la Torre, Manuel; Pamplona Gras, Reinald; Miquel, Eva; Kerkeni, M.; Hernández, Cristina; Simó, Rafael; Lecube Torelló, Albert (Japan Atherosclerosis Society, 2019)
      AIM: Advanced glycation end-products (AGEs) have been involved in the atherogenic process in the high-risk population. The goal of this study was to demonstrate that AGEs are related to subclinical atheromatous disease in ...