Now showing items 1-16 of 16

    • A pathway involving HDAC5, cFLIP and caspases regulates expression of the splicing regulator polypyrimidine tract binding protein in the heart 

      Ye, Junmei; Llorian, Miriam; Cardona, Maria; Rongvaux, Anthony; Moubarak, Rana S.; Comella i Carnicé, Joan Xavier; Bassel-Duby, Rhonda; Flavell, Richard A.; Olson, Eric N.; Smith, Christopher W. J.; Sanchis, Daniel (Company of Biologists Ltd., 2013)
      Polypyrimidine tract binding protein (PTB) regulates pre-mRNA splicing, having special relevance for determining gene expression in the differentiating muscle. We have previously shown that PTB protein abundance is ...
    • AKT2 Blocks Nucleus Translocation of Apoptosis-Inducing Factor (AIF) and Endonuclease G (EndoG) While Promoting Caspase Activation during Cardiac Ischemia 

      Yang, Shuai; Zhao, Xinmei; Xu, Hui; Chen, Fan; Xu, Yitao; Li, Zhe; Sanchis, Daniel; Jin, Liang; Zhang, Yubin; Ye, Junmei (MDPI, 2017)
      The AKT (protein kinase B, PKB) family has been shown to participate in diverse cellular processes, including apoptosis. Previous studies demonstrated that protein kinase B2 (AKT2 − / − ) mice heart was sensitized to ...
    • BCL-XL regulates TNF-α-mediated cell death independently of NF-κB, FLIP and IAPs 

      Gozzelino, Raffaella; Solé Serra, Carme; Llecha Cano, Núria; Segura Ginard, Miguel Francisco; Moubarak, Rana S.; Iglesias Guimarais, Victoria; Pérez García, María José; Reix, Stéphanie; Zhang, Jisheng; Badiola, Nahuai; Sanchis, Daniel; Rodríguez Álvarez, José; Trullas, Ramon; Yuste Mateos, Víctor J. (Víctor José); Comella i Carnicé, Joan Xavier (Springer Nature, 2008)
      Upon activation, tumor necrosis factor alpha (TNF-α) receptor can engage apoptotic or survival pathways. Inhibition of macromolecular synthesis is known to sensitize cells to TNF-α-induced cell death. It is believed that ...
    • Cardiomyocyte hypertrophy induced by Endonuclease G deficiency requires reactive oxygen radicals accumulation and is inhibitable by the micropeptide humanin. 

      Blasco Angulo, Natividad; Cámara, Yolanda; Núñez, Estefanía; Beà, Aida; Barés Junqué, Gisel; Forné, Carles; Ruiz Meana, Marisol; Girón, Cristina; Barba, Ignasi; García Arumí, Elena; García Dorado, David; Vázquez, Jesús; Martí, Ramón; Llovera i Tomàs, Marta; Sanchis, Daniel (Elsevier, 2018-03-01)
      The endonuclease G gene (Endog), which codes for a mitochondrial nuclease, was identified as a determinant of cardiac hypertrophy. How ENDOG controls cardiomyocyte growth is still unknown. Thus, we aimed at finding the ...
    • Developmental silencing and independency from E2F of apoptotic gene expression in postmitotic tissues 

      Zhang, Jisheng; Bahi i Pla, Núria; Zubiaga, Ana M.; Comella i Carnicé, Joan Xavier; Llovera i Tomàs, Marta; Sanchis, Daniel (Wiley, 2007)
      The involvement of caspases in postmitotic cell death is controversial. Here we report that adult brain and heart are devoid of many key pro-apoptotic proteins due to a progressive postnatal silencing event involving a ...
    • EndoG links Bnip3-induced mitochondrial damage and caspase-independent DNA fragmentation in ischemic cardiomyocytes 

      Zhang, Jisheng; Ye, Junmei; Altafaj, Albert; Cardona Colom, Maria; Bahi i Pla, Núria; Llovera i Tomàs, Marta; Cañas, Xavier; Cook, Stuart A.; Comella i Carnicé, Joan Xavier; Sanchis, Daniel (Public Library of Science (PLoS), 2011)
      Mitochondrial dysfunction, caspase activation and caspase-dependent DNA fragmentation are involved in cell damage in many tissues. However, differentiated cardiomyocytes repress the expression of the canonical apoptotic ...
    • Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function 

      McDermott Roe, Chris; Ye, Junmei; Ahmed, Rizwan; Sun, Xi-Ming; Serafín, Anna; Ware, James; Bottolo, Leonardo; Muckett, Phil; Cañas, Xavier; Zhang, Jisheng; Rowe, Glenn C.; Buchan, Rachel; Lu, Han; Braithwaite, Adam; Mancini, Massimiliano; Hauton, David; Martí, Ramon; García Arumí, Elena; Hubner, Norbert; Jacob, Howard; Serikawa, Tadao; Zidek, Vaclav; Papousek, Frantisek; Kolar, Frantisek; Cardona Colom, Maria; Ruiz Meana, Marisol; García Dorado, David; Comella i Carnicé, Joan Xavier; Felkin, Leanne E.; Barton, Paul J. R.; Zoltan Arany; Pravenec, Michal; Petretto, Enrico; Sanchis, Daniel; Cook, Stuart A. (Macmillan Publishers Limited, 2011)
      Left ventricular mass (LVM) is a highly heritable trait1 and an independent risk factor for all-cause mortality2. So far, genome-wide association studies have not identified the genetic factors that underlie LVM variation3, ...
    • Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart 

      Cardona, Maria; López, Juan Antonio; Serafín, Anna; Rongvaux, Anthony; Inserte Igual, Javier; García-Dorado, David; Flavell, Richard; Llovera i Tomàs, Marta; Cañas, Xavier; Vázquez, Jesús; Sanchis, Daniel (Public Library of Science, 2015-06-29)
      Executioner caspase-3 and -7 are proteases promoting cell death but non-apoptotic roles are being discovered. The heart expresses caspases only during development, suggesting they contribute to the organ maturation process. ...
    • FAIM-L Is an IAP-Binding Protein That Inhibits XIAP Ubiquitinylation and Protects from Fas-Induced Apoptosis 

      Moubarak, Rana S.; Planells Ferrer, Laura; Urresti, Jorge; Reix, Stéphanie; Segura Ginard, Miguel Francisco; Carriba, Paulina; Marqués Fernàndez, Fernando; Solé Serra, Carme; Llecha Cano, Núria; López Soriano, Joaquin; Sanchis, Daniel; Yuste Mateos, Víctor J. (Víctor José); Comella i Carnicé, Joan Xavier (Society for Neuroscience, 2013)
      The neuronal long isoform of Fas Apoptotic Inhibitory Molecule (FAIM-L) protects from death receptor (DR)-induced apoptosis, yet its mechanism of protection remains unknown. Here, we show that FAIM-L protects rat neuronal ...
    • Frataxin deficiency in neonatal rat ventricular myocytes targets mitochondria and lipid metabolism 

      Obis Monné, Èlia; Irazusta, Verónica Patricia; Sanchis, Daniel; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (Elsevier, 2014)
      Friedreich ataxia (FRDA) is a hereditary disease caused by deficient frataxin expression. This mitochondrial protein has been related to iron homeostasis, energy metabolism, and oxidative stress. Patients with FRDA experience ...
    • Genome Wide Meta-Analysis identifies common genetic signatures shared by heart function and Alzheimer’s disease 

      Sáez, M. E.; González-Pérez, Antonio; Hernández-Olasagarre, B.; Beà, Aida; Moreno-Grau, S.; de Rojas, I.; Monté-Rubio, G.; Orellana, A.; Valero, S.; Comella i Carnicé, Joan Xavier; Sanchis, Daniel; Ruiz, Agustín (Nature Publishing Group, 2019)
      Echocardiography has become an indispensable tool for the study of heart performance, improving the monitoring of individuals with cardiac diseases. Diverse genetic factors associated with echocardiographic measures have ...
    • Histone deacetylase inhibitors promote glioma cell death by G2 checkpoint abrogation leading to mitotic catastrophe 

      Cornago Protomártir, Marta; Garcia-Alberich, C.; Blasco Angulo, Natividad; Vall-llaura Espinosa, Núria; Nàger Grifo, Mireia; Herreros Danés, Judit; Comella i Carnicé, Joan Xavier; Sanchis, Daniel; Llovera i Tomàs, Marta (Nature Publishing Group, 2014-10-02)
      Glioblastoma multiforme is resistant to conventional anti-tumoral treatments due to its infiltrative nature and capability of relapse; therefore, research efforts focus on characterizing gliomagenesis and identifying ...
    • Polypyrimidine tract binding proteins (PTB) regulate the expression of apoptotic genes and susceptibility to caspase-dependent apoptosis in differentiating cardiomyocytes 

      Zhang, Jisheng; Bahi i Pla, Núria; Comella i Carnicé, Joan Xavier; Sanchis, Daniel (Nature Publishing Group, 2009)
      Cardiac morphologic abnormalities in mice deficient for key regulators of the caspase-dependent signaling underscored its role in heart development. However, the mechanisms regulating apoptotic gene expression in the ...
    • The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-κB signaling 

      Solé Serra, Carme; Dolcet Roca, Xavier; Segura Ginard, Miguel Francisco; Gutierrez, Humberto; Diaz Meco, Maria Teresa; Gozzelino, Raffaella; Sanchis, Daniel; Bayascas Ramírez, José Ramón; Gallego, Carme; Moscat, Jorge; Davies, Alun M.; Comella i Carnicé, Joan Xavier (Rockefeller University Press, 2004)
      Fas apoptosis inhibitory molecule (FAIM) is a protein identified as an antagonist of Fas-induced cell death. We show that FAIM overexpression fails to rescue neurons from trophic factor deprivation, but exerts a marked ...
    • Translation of Myocyte Enhancer Factor-2 is induced by hypertrophic stimuli in cardiomyocytes through a Calcineurin-dependent pathway 

      Ye, Junmei; Cardona, Maria; Llovera i Tomàs, Marta; Comella i Carnicé, Joan Xavier; Sanchis, Daniel (Elsevier, 2012)
      The Myocyte Enhancer Factor-2 (MEF2) family of transcription factors regulates gene expression during cardiomyocyte differentiation and adaptation of the myocardium to stress. MEF2 activity is enhanced by increasing its ...
    • Ubiquitination of TrkA by Nedd4-2 regulates receptor lysosomal targeting and mediates receptor signaling 

      Georgieva, Maya V.; Pablo Llavall, Yolanda de; Sanchis, Daniel; Comella i Carnicé, Joan Xavier; Llovera i Tomàs, Marta (Wiley, 2011)
      The nerve growth factor receptor TrkA (tropomyosin-related kinase receptor) participates in the survival and differentiation of several neuronal populations. The C-terminal tail of TrkA contains a PPXY motif, the binding ...