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    • Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer 

      Signoretti, Sabina; Di Marcotullio, Lucia; Richardson, Andrea; Ramaswamy, Sridhar; Isaac, Beth; Rué i Monné, Montserrat; Monti, Franco; Loda, Massimo; Pagano, Michele (American Society for Clinical Investigation, 2002)
      Estrogen receptor (ER) expression and Her-2 amplification define specific subsets of breast tumors for which specific therapies exist. The S-phase kinase-associated protein Skp2 is required for the ubiquitin-mediated degradation ...