Now showing items 1-16 of 16

    • Calpain activation and CaMKIV reduction in spinal cords from hSOD1G93A mouse model 

      Gou Fabregas, Myriam; Ramírez-Núñez, Omar; Cacabelos Barral, Daniel; Bahi i Pla, Núria; Portero Otín, Manuel; Garcera, Ana; Soler i Tatché, Rosa Ma. (Elsevier, 2014)
      Amyotrophic Lateral Sclerosis (ALS), a severe neurodegenerative disease, affects the upper and lower motor neurons in the brain and spinal cord. In some studies, ALS disease progression has been associatedwith an increase ...
    • Depletion of oxidative and endoplasmic reticulum stress regulators in Pick disease 

      Ilieva, Ekaterina V.; Naudí i Farré, Alba; Kichev, Anton Vladimirov; Ferrer, Isidre; Pamplona Gras, Reinald; Portero Otín, Manuel (Elsevier, 2010)
      Both oxidative and endoplasmic reticulum (ER) stress is associated with multiple neurodegenerative, age-related diseases. The rare disorder Pick disease (PiD) shares some pathological hallmarks of other neurodegenerative ...
    • Dietary protein restriction decreases oxidative protein damage, peroxidizability index, and mitochondrial complex I content in rat liver 

      Ayala Jové, Ma. Victoria (Maria Victoria); Naudí i Farré, Alba; Sanz, Alberto; Caro, Pilar; Portero Otín, Manuel; Barja, Gustavo; Pamplona Gras, Reinald (Oxford University Press, 2007)
      Caloric restriction (CR) decreases oxidative damage, which contributes to the slowing of aging rate. It is not known if such decreases are due to calories themselves or specific dietary components. In this work, the ...
    • Effect of 8.5% and 25% caloric restriction on mitochondrial free radical production and oxidative stress in rat liver 

      Gómez, José; Caro, Pilar; Naudí i Farré, Alba; Portero Otín, Manuel; Pamplona Gras, Reinald; Barja, Gustavo (Springer Verlag, 2007)
      Previous studies have consistently shown that 40% caloric restriction (CR) decreases the rate of mitochondrial ROS production and steady-state levels of markers of oxidative damage to macromolecules including mitochondrial ...
    • Estudio de intervención aleatorizado para evaluar la prevalencia de enfermedad ateromatosa y renal ocultas y su impacto en la morbimortalidad: Proyecto ILERVA 

      Betriu i Bars, M. Àngels; Farràs-Sallés, Cristina; Abajo, María; Martínez Alonso, Montserrat; Arroyo, David; Barbé Illa, Ferran; Buti, Miquel; Lecube Torelló, Albert; Portero Otín, Manuel; Purroy Garcia, Francisco; Torres, Gerard; Valdivielso Revilla, José Manuel; Fernández i Giráldez, Elvira (Sociedad Española de Nefrología, 2016)
      Antecedentes y objetivos: La enfermedad renal crónica (ERC) y la ateromatosis son 2 enfermedades interrelacionadas que aumentan el riesgo de morbimortalidad cardiovascular. Los objetivos del proyecto ILERVAS son: 1) conocer ...
    • Faecal bacterial and short-chain fatty acids signature in hypercholesterolemia 

      Granado-Serrano, Ana Belén; Martín Garí, Meritxell; Sánchez, V.; Riart Solans, M.; Berdún Hernández, Rebeca; Ludwig, Iziar A.; Rubió Piqué, Laura; Vilaprinyo Terré, Ester; Portero Otín, Manuel; Serrano Casasola, José Carlos Enrique (Nature Research, 2019)
      Gut microbiota has been suggested to affect lipid metabolism. The objective of this study was to characterize the faecal microbiota signature and both short chain fatty acids (SCFAs) and bile acids (BA) profile of ...
    • Metabolomics predicts neuroimaging characteristics of transient ischemic attack patients 

      Purroy Garcia, Francisco; Cambray Carner, Serafí; Mauri-Capdevila, Gerard; Jové Font, Mariona; Sanahuja Montesinos, Jordi; Farré, Joan; Benabdelhak Abbou, Ikram; Molina Seguin, Jessica; Colàs Campàs, Laura; Begué Gómez, Robert; Gil, M. Isabel; Pamplona Gras, Reinald; Portero Otín, Manuel (Elsevier, 2016)
      Background: Neuroimaging is essential for the diagnosis and prognosis of transient ischemic attack (TIA). The discovery of a plasmatic biomarker related to neuroimaging findings is of enormous interest because, despite ...
    • Metabolomics predicts stroke recurrence after transient ischemic attack 

      Jové Font, Mariona; Mauri-Capdevila, Gerard; Suárez-Luis, Idalmis; Cambray Carner, Serafí; Sanahuja Montesinos, Jordi; Quilez Martínez, Alejandro; Farré, Joan; Benabdelhak Abbou, Ikram; Pamplona Gras, Reinald; Portero Otín, Manuel; Purroy Garcia, Francisco (American Academy of Neurology, 2015)
      Objective: To discover, by using metabolomics, novel candidate biomarkers for stroke recurrence (SR) with a higher prediction power than present ones. Methods: Metabolomic analysis was performed by liquid chromatography ...
    • Metabotyping human endometrioid endometrial adenocarcinoma reveals an implication of endocannabinoid metabolism 

      Jové Font, Mariona; Gatius Calderó, Sònia; Yeramian Hakim, Andree; Portero Otín, Manuel; Eritja Sánchez, Núria; Santacana Espasa, Maria; Colás, Eva; Ruiz, M.; Pamplona Gras, Reinald; Matias-Guiu, Xavier (Impact Journals, 2016)
      Metabolomics, an essential technique in precision medicine, contributes to the molecular fingerprinting of tumours, further helping to understand their pathogenesis. In this work, using a LC-ESI-QTOF-MS/MS platform, we ...
    • Mitochondrial Dysfunction and Oxidative and Endoplasmic Reticulum Stress in Argyrophilic Grain Disease 

      Ilieva, Ekaterina V.; Kichev, Anton Vladimirov; Naudí i Farré, Alba; Ferrer, Isidre; Pamplona Gras, Reinald; Portero Otín, Manuel (Oxford University Press, 2011)
      Argyrophilic grain disease (AGD) is characterized by the accumulation of hyperphosphorylated 4R tau in dendritic varicosities (i.e."grains") in neurons and pretangles in certain areas of the cerebral cortex and other brain ...
    • Plant-derived phenolics inhibit the accrual of structurally characterised protein and lipid oxidative modifications 

      Soler Cantero, Arantza; Jové Font, Mariona; Cacabelos Barral, Daniel; Boada Pallàs, Jordi; Naudí i Farré, Alba; Romero Fabregat, Mª Paz; Cassanyé, Anna; Serrano Casasola, José Carlos Enrique; Arola i Ferrer, Lluís; Valls, Josep; Bellmunt i Curcó, Josepa; Prat Corominas, Joan; Pamplona Gras, Reinald; Portero Otín, Manuel; Motilva Casado, Mª José (Public Library of Science, 2012)
      Epidemiological data suggest that plant-derived phenolics beneficial effects include an inhibition of LDL oxidation. After applying a screening method based on 2,4-dinitrophenyl hydrazine- protein carbonyl reaction to 21 ...
    • Plurality of opinion, scientific discourse and pseudoscience: an in depth analysis of the Séralini et al. study claiming that Roundup™ Ready corn or the herbicide Roundup™ cause cancer in rats 

      Arjó Pont, Gemma; Portero Otín, Manuel; Piñol Felis, Carme; Viñas Salas, Joan; Matias-Guiu, Xavier; Capell Capell, Teresa; Bartholomaeus, Andrew; Parrot, Wayne; Christou, Paul (Springer Verlag, 2013)
      A recent paper published in the journal Food and Chemical Toxicology presents the results of a long-term toxicity study related to a widely-used commercial herbicide (RoundupTM) and a Rounduptolerant genetically modified ...
    • Psoriasis, metabolic syndrome and cardiovascular risk factors. A population-based study. 

      Fernández Armenteros, José Manuel; Gómez Arbonés, Javier; Buti, Miquel; Betriu i Bars, M. Àngels; Sanmartín Novell, Verònica; Ortega Bravo, Marta; Martínez Alonso, Montserrat; Garí Marsol, Eloi; Portero Otín, Manuel; Santamaria-Babi, L.; Casanova i Seuma, Josep M. (Josep Manel) (Wiley, 2019)
      Abstract Background: Psoriasis is a very prevalent systemic chronic inflammatory disease. Major cardiovascular events are the main cause of mortality in these patients which suggests an association between psoriasis and ...
    • Sixty years old is the breakpoint of human frontal cortex aging 

      Cabré Cucó, Rosanna; Naudí i Farré, Alba; Dominguez Gonzalez, Mayelin; Ayala Jové, Ma. Victoria (Maria Victoria); Jové Font, Mariona; Mota Martorell, Natàlia; Piñol Ripoll, Gerard; Gil Villar, M. Pilar; Rué i Monné, Montserrat; Portero Otín, Manuel; Ferrer, Isidre; Pamplona Gras, Reinald (Elsevier, 2017)
      Human brain aging is the physiological process which underlies as cause of cognitive decline in the elderly and the main risk factor for neurodegenerative diseases such as Alzheimer's disease. Human neurons are functional ...
    • Tumour-microenvironmental blood flow determines a metabolomic signature identifying lysophospholipids and resolvin D as biomarkers in endometrial cancer patients 

      Eritja Sánchez, Núria; Jové Font, Mariona; Eldevik Fasmer, Kristine; Gatius Calderó, Sònia; Portero Otín, Manuel; Trovik, Jone; Krakstad, Camilla; Sol, Joaquim; Pamplona Gras, Reinald; Haldorsen, Ingfrid S.; Matias-Guiu, Xavier (Impact Journals, 2017)
      Purpose: We aimed to study the potential influence of tumour blood flow –obtained from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)- in the metabolomic profiles of endometrial tumours. Methods: Liquid ...
    • When cholesterol is not cholesterol: a note on the enzymatic determination of its concentration in model systems containing vegetable extracts 

      Jové Font, Mariona; Serrano Casasola, José Carlos Enrique; Bellmunt i Curcó, Josepa; Cassanyé, Anna; Anglès, Neus; Reguant, Jordi; Morelló, José R.; Pamplona Gras, Reinald; Portero Otín, Manuel (BioMed Central, 2010)
      Background: Experimental evidences demonstrate that vegetable derived extracts inhibit cholesterol absorption in the gastrointestinal tract. To further explore the mechanisms behind, we modeled duodenal contents with several ...