Now showing items 1-3 of 3

    • A SUMO-Dependent Step during Establishment of Sister Chromatid Chohesion 

      Almedawar, Seba; Colomina i Gabarrella, Neus; Bermúdez López, Marcelino; Pociño Merino, Irene; Torres Rosell, Jordi (Elsevier, 2012-09-11)
      Cohesin is a protein complex that ties sister DNA molecules from the time of DNA replication until the metaphase to anaphase transition. Current models propose that the association of the Smc1, Smc3, and Scc1/Mcd1 subunits ...
    • ATPase-dependent control of the Mms21 SUMO ligase during DNA repair 

      Bermúdez López, Marcelino; Pociño Merino, Irene; Sánchez, Humberto; Bueno, Andrés; Guasch, Clàudia; Almedawar, Seba; Brú i Virgili, Sergi; Garí Marsol, Eloi; Wyman, Claire; Reverter Cendrós, David; Colomina i Gabarrella, Neus; Torres Rosell, Jordi (Plos Biology, 2015-03-12)
      Modification of proteins by SUMO is essential for the maintenance of genome integrity. During DNA replication, the Mms21-branch of the SUMO pathway counteracts recombination intermediates at damaged replication forks, thus ...
    • Sumoylation of Smc5 Promotes Error-free Bypass at Damaged Replication Forks 

      Zapatka, Mariel; Pociño Merino, Irene; Heluani-Gahete, Hayat; Bermúdez López, Marcelino; Tarrés, Marc; Ibars, Eva; Solé-Soler, Roger; Gutiérrez-Escribano, Pilar; Apostolova, Sonia; Casas Herranz, Celia; Aragon, Luis; Wellinger, Ralf Erik; Colomina i Gabarrella, Neus; Torres Rosell, Jordi (Elsevier, 2019)
      Replication of a damaged DNA template can threaten the integrity of the genome, requiring the use of various mechanisms to tolerate DNA lesions. The Smc5/6 complex, together with the Nse2/Mms21 SUMO ligase, plays essential ...