Browsing Articles publicats (Ciències Mèdiques Bàsiques) by Author "Periyakaruppiah, Ambika"
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Autophagy modulators regulate survival motor neuron protein stability in motoneurons
Periyakaruppiah, Ambika; Fuente Ruiz, Sandra de la; Arumugam, Saravanan; Bahi i Pla, Núria; Garcera, Ana; Soler i Tatché, Rosa Ma. (Elsevier, 2016)SpinalMuscular Atrophy (SMA), a neurodegenerative disorder primarily affecting motoneurons (MNs), is caused by the loss of the Survival Motor Neuron 1 (SMN1) gene and reduced levels of full-length survival motor neuron (SMN) ... -
Calpain Inhibition Increases SMN Protein in Spinal Cord Motoneurons and Ameliorates the Spinal Muscular Atrophy Phenotype in Mice
Fuente Ruiz, Sandra de la; Sansa Zaragoza, Alba; Periyakaruppiah, Ambika; Garcera, Ana; Soler i Tatché, Rosa Ma. (Springer Verlag, 2018)Spinal muscular atrophy (SMA), a leading genetic cause of infant death, is caused by the loss of survival motor neuron 1 (SMN1) gene. SMA is characterized by the degeneration and loss of spinal cord motoneurons (MNs), ... -
Regulation of survival motor neuron protein by the nuclear factor-kappa B pathway in mouse spinal cord motoneurons
Arumugam, Saravanan; Tasheva, Stefka Mincheva; Periyakaruppiah, Ambika; Fuente Ruiz, Sandra de la; Soler i Tatché, Rosa Ma.; Garcera, Ana (Springer Verlag, 2017-08-14)Survival motor neuron (SMN) protein deficiency causes the genetic neuromuscular disorder spinal muscular atrophy (SMA), characterized by spinal cord motoneuron degeneration. Since SMN protein level is critical to disease ... -
Survival motor neuron protein reduction deregulates autophagy in spinal cord motoneurons in vitro
Garcera, Ana; Bahi i Pla, Núria; Periyakaruppiah, Ambika; Arumugam, Saravanan; Soler i Tatché, Rosa Ma. (Macmillan Publishers Limited, 2013)Spinal muscular atrophy (SMA) is a genetic disorder characterized by degeneration of spinal cord motoneurons (MNs), resulting in muscular atrophy and weakness. SMA is caused by mutations in the Survival Motor Neuron 1 ...