Now showing items 1-10 of 10

    • Barley β-glucan accelerates wound healing by favoring migration versus proliferation of human dermal fibroblasts 

      Pérez Fusté, Noel; Guasch Vallés, Marta; Guillén, Pere; Anerillas, Carlos; Cemeli, Tània; Pedraza González, Neus; Ferrezuelo, Francisco; Encinas Martín, Mario; Moralejo Vidal, Mª Angeles; Garí Marsol, Eloi (Elsevier, 2019)
      β-Glucans are considered candidates for the medication in different human pathologies. In this work, we have purified β-glucan from a selected barley line and tested their effects in primary human dermal fibroblasts. ...
    • Characterization of cytoplasmic cyclin D1 as a marker of invasiveness in cancer 

      Pérez Fusté, Noel; Castelblanco Echavarría, Esmeralda; Felip, Isidre; Santacana Espasa, Maria; Fernández-Hernández, Rita; Gatius Calderó, Sònia; Pedraza González, Neus; Pallares, Judit; Cemeli, Tània; Valls Marsal, Joan; Tarres, Marc; Ferrezuelo, Francisco; Dolcet Roca, Xavier; Matias-Guiu, Xavier; Garí Marsol, Eloi (Impact Journals, 2016)
      Cyclin D1 (Ccnd1) is a proto-oncogen amplified in many different cancers and nuclear accumulation of Ccnd1 is a characteristic of tumor cells. Ccnd1 activates the transcription of a large set of genes involved in cell ...
    • Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin 

      Pérez Fusté, Noel; Fernández Hernández, Rita; Cemeli, Tània; Mirantes Barbeito, Cristina; Pedraza González, Neus; Rafel i Borrell, Marta; Torres Rosell, Jordi; Colomina i Gabarrella, Neus; Ferrezuelo, Francisco; Dolcet Roca, Xavier; Garí Marsol, Eloi (Nature Publishing Group, 2016)
      Cyclin D1 (Ccnd1) together with its binding partner Cdk4 act as a transcriptional regulator to control cell proliferation and migration, and abnormal Ccnd1 Cdk4 expression promotes tumour growth and metastasis. While ...
    • Cytoplasmic Cyclin D1 regulates glioblastoma dissemination 

      Cemeli, Tània; Guasch Vallés, Marta; Nàger Grifo, Mireia; Felip, Isidre; Cambray Carner, Serafí; Santacana Espasa, Maria; Gatius Calderó, Sònia; Pedraza González, Neus; Dolcet Roca, Xavier; Ferrezuelo, Francisco; Schuhmacher, Alberto J.; Herreros Danés, Judit; Garí Marsol, Eloi (Wiley, 2019)
      Glioblastoma (GBM) is a highly invasive brain neoplasia with an elevated recurrence rate after surgical resection. The CyclinD1 (Ccnd1)/Cdk4-RB1 axis is frequently altered in GBM, leading to over-proliferation by RB1 ...
    • Developmental and Tissue-Specific Involvement of Peroxisome Proliferator-Activated Receptor-α in the Control of Mouse Uncoupling Protein-3 Gene Expression 

      Pedraza González, Neus; Rosell, Meritxell; Villarroya, Joan; Iglesias, Roser; Gonzalez, Frank J.; Solanes, Gemma; Villarroya, Francesc (Endocrine Society, 2006)
      Uncoupling protein-3 (UCP3) is a member of the mitochondrial carrier family expressed preferentially in skeletal muscle and heart. It appears to be involved in metabolic handling of fatty acids in a way that minimizes ...
    • Protective role of renal proximal tubular alpha-synuclein in the pathogenesis of kidney fibrosis 

      Bozić Stanojević, Milica; Caus, Maite; Rodrigues-Diez, Raul; Pedraza González, Neus; Ruiz-Ortega, Marta; Garí Marsol, Eloi; Gallel Vicente, María del Pilar; Panadés, Maria José; Martinez, Ana; Fernández i Giráldez, Elvira; Valdivielso Revilla, José Manuel (Nature Publishing Group, 2020)
      Kidney fibrosis is a highly deleterious process and a final manifestation of chronic kidney disease. Alpha-(α)-synuclein (SNCA) is an actin-binding neuronal protein with various functions within the brain; however, its ...
    • Protein Kinase KIS Localizes to RNA Granules and Enhances Local Translation 

      Cambray Carner, Serafí; Pedraza González, Neus; Rafel i Borrell, Marta; Garí Marsol, Eloi; Aldea, Martí; Gallego, Carme (American Society for Microbiology, 2009)
      The regulation of mRNA transport is a fundamental process for cytoplasmic sorting of transcripts and spatially controlled translational derepression once properly localized. There is growing evidence that translation is ...
    • Recruitment of Staufen2 Enhances Dendritic Localization of an Intron-Containing CaMKIIα mRNA 

      Ortiz, Raul; Georgieva, Maya V.; Gutiérrez, Sara; Pedraza González, Neus; Fernández-Moya, Sandra M.; Gallego, Carme (Elsevier, 2017)
      Regulation of mRNA localization is a conserved cellular process observed in many types of cells and organisms. Asymmetrical mRNA distribution plays a particularly important role in the nervous system, where local translation ...
    • Regulation of small GTPase activity by G1 cyclins 

      Pedraza González, Neus; Cemeli, Tània; Monserrat Monserrat, Maria Ventura; Garí Marsol, Eloi; Ferrezuelo, Francisco (Taylor & Francis, 2017-01-27)
      Together with a cyclin-dependent kinase (CDK) partner G1 cyclins control cell cycle entry by phosphorylating a number of nuclear targets and releasing a transcriptional program at the end of G1 phase. Yeast G1 cyclins also ...
    • Thyroid hormones directly activate the expression of the human and mouse uncoupling protein-3 genes through a thyroid response element in the proximal promoter region 

      Solanes, Gemma; Pedraza González, Neus; Calvo Garrido, Verónica; Vidal Puig, Antonio; Lowell, Bradford B.; Villarroya, Francesc (Portland Press, 2005)
      The transcription of the human UCP3 (uncoupling protein-3) gene in skeletal muscle is tightly regulated by metabolic signals related to fatty acid availability. However, changes in thyroid status also modulate UCP3 gene ...