Browsing Articles publicats (Ciències Mèdiques Bàsiques) by Author "Pallares, Judit"
Now showing items 1-7 of 7
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Abnormalities in the NF-κB family and related proteins in endometrial carcinoma
Pallares, Judit; Martínez-Guitarte, Jose Luis; Dolcet Roca, Xavier; Llobet Navàs, David; Rué i Monné, Montserrat; Palacios, José; Prat, Jaime; Matias-Guiu, Xavier (Wiley, 2004)The NF-κB family of transcription factors regulates a wide variety of cellular processes including cell growth, differentiation, and apoptosis. A tissue microarray was constructed from paraffin wax-embedded blocks from ... -
An inducible knockout mouse to model the cellautonomous role of PTEN in initiating endometrial, prostate and thyroid neoplasias
Mirantes Barbeito, Cristina; Eritja Sánchez, Núria; Dosil, Maria Alba; Santacana Espasa, Maria; Pallares, Judit; Gatius Calderó, Sònia; Bergadà Bertran, Laura; Maiques Carlos, Oscar; Matias-Guiu, Xavier; Dolcet Roca, Xavier (Company of Biologists, 2013)PTEN is one of the most frequently mutated tumor suppressor genes in human cancers. The role of PTEN in carcinogenesis has been validated by knockout mouse models. PTEN heterozygous mice develop neoplasms in multiple ... -
Characterization of cytoplasmic cyclin D1 as a marker of invasiveness in cancer
Pérez Fusté, Noel; Castelblanco Echavarría, Esmeralda; Felip, Isidre; Santacana Espasa, Maria; Fernández-Hernández, Rita; Gatius Calderó, Sònia; Pedraza González, Neus; Pallares, Judit; Cemeli, Tània; Valls Marsal, Joan; Tarres, Marc; Ferrezuelo, Francisco; Dolcet Roca, Xavier; Matias-Guiu, Xavier; Garí Marsol, Eloi (Impact Journals, 2016)Cyclin D1 (Ccnd1) is a proto-oncogen amplified in many different cancers and nuclear accumulation of Ccnd1 is a characteristic of tumor cells. Ccnd1 activates the transcription of a large set of genes involved in cell ... -
FLIP is frequently expressed in endometrial carcinoma and has a role in resistance to TRAIL-induced apoptosis
Dolcet Roca, Xavier; Llobet Navàs, David; Pallares, Judit; Rué i Monné, Montserrat; Comella i Carnicé, Joan Xavier; Matias-Guiu, Xavier (Nature Publishing Group, 2005)The FLICE-inhibitory protein (FLIP) plays a key role in the regulation of apoptosis triggered by death ligands. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to induce apoptosis in some types ... -
Immunohistochemical analysis of PTEN in endometrial carcinoma: a tissue microarray study with a comparison of four commercial antibodies in correlation with molecular abnormalities
Pallares, Judit; Bussaglia, Elena; Martínez-Guitarte, Jose Luis; Dolcet Roca, Xavier; Llobet Navàs, David; Rué i Monné, Montserrat; Sanchez-Verde, Lidia; Palacios, José; Prat, Jaime; Matias-Guiu, Xavier (Nature Publishing Group, 2005)The tumor suppressor gene PTEN/MMAC1 is located on chromosome 10q23.3. Inactivation of PTEN, either by mutations, deletions, or promoter hypermethylation, has been identified in a wide variety of tumors. Inactivation of ... -
Optimal protocol for PTEN immunostaining; role of analytical and preanalytical variables in PTEN staining in normal and neoplastic endometrial, breast, and prostatic tissues
Maiques Carlos, Oscar; Santacana Espasa, Maria; Valls Marsal, Joan; Pallares, Judit; Mirantes Barbeito, Cristina; Gatius Calderó, Sònia; García Dios, Diego Andrés; Amant, Frederic; Pedersen, Hans Christian; Dolcet Roca, Xavier; Matias-Guiu, Xavier (Elsevier, 2014)In some tumors, phosphatase and tensin homolog (PTEN) inactivation may have prognostic importance and predictive value for targeted therapies. Immunohistochemistry (IHC) may be an effective method to demonstrate PTEN loss. ... -
The role of morbid obesity in the promotion of metabolic disruptions and non-alcoholic steatohepatitis by Helicobacter Pylori
Lecube Torelló, Albert; Valladares, Silvia; López Cano, Carolina; Gutiérrez Carrasquilla, Liliana; Ciudin, Andreea; Fort, José Manuel; Reñé Espinet, Josep Maria; Matias-Guiu, Xavier; Torres, Inés de; Bueno Díez, Marta; Pallares, Judit; Baena-Fustegueras, Juan A (Public Library of Science, 2016)Helicobacter pylory (HP) infection has been associated to an increased rate of type 2 diabetes (T2D) and liver disease through its effect on insulin resistance and systemic inflammation. However, results are inconstant ...