Now showing items 1-4 of 4

    • A Smad3-PTEN regulatory loop controls proliferation and apoptotic responses to TGF-β in mouse endometrium 

      Eritja Sánchez, Núria; Felip, Isidre; Dosil Garcia, Maria Alba; Vigezzi, Lucia; Mirantes Barbeito, Cristina; Yeramian Hakim, Andree; Navaridas Fernández de Bobadilla, Raúl; Santacana Espasa, Maria; Llobet Navàs, David; Yoshimura, Akihiko; Nomura, Masatoshi; Encinas Martín, Mario; Matias-Guiu, Xavier; Dolcet Roca, Xavier (Nature Publishing Group, 2017-05-19)
      The TGF-β/Smad and the PI3K/AKT signaling pathways are important regulators of proliferation and apoptosis, and their alterations lead to cancer development. TGF-β acts as a tumor suppressor in premalignant cells, but it ...
    • ENDOG Impacts on Tumor Cell Proliferation and Tumor Prognosis in the Context of PI3K/PTEN Pathway Status 

      Barés Junqué, Gisel; Beà Tàrrega, Aida; Hernández, Luís; Navaridas Fernández de Bobadilla, Raúl; Felip, Isidre; Megino-Luque, Cristina; Blasco Angulo, Natividad; Nadeu, Ferran; Campo, Elías; Llovera i Tomàs, Marta; Dolcet Roca, Xavier; Sanchis, Daniel (MDPI, 2021)
      EndoG influences mitochondrial DNA replication and is involved in somatic cell proliferation. Here, we investigated the effect of ENDOG/Endog expression on proliferation in different tumor models. Noteworthy, ENDOG ...
    • Involvement of the mitochondrial nuclease EndoG in the regulation of cell proliferation through the control of reactive oxygen species 

      Blasco Angulo, Natividad; Beà Tàrrega, Aida; Barés Junqué, Gisel; Girón, Cristina; Navaridas Fernández de Bobadilla, Raúl; Irazoki, Andrea; López-Lluch, Guillermo; Zorzano, Antonio; Dolcet Roca, Xavier; Llovera i Tomàs, Marta; Sanchis, Daniel (Elsevier, 2020-10-05)
      The apoptotic nuclease EndoG is involved in mitochondrial DNA replication. Previous results suggested that, in addition to regulate cardiomyocyte hypertrophy, EndoG could be involved in cell proliferation. Here, by using ...
    • Palbociclib has antitumour effects on Pten-deficient endometrial neoplasias 

      Dosil Garcia, Maria Alba; Mirantes Barbeito, Cristina; Eritja Sánchez, Núria; Felip, Isidre; Navaridas Fernández de Bobadilla, Raúl; Gatius Calderó, Sònia; Santacana Espasa, Maria; Colás, Eva; Moiola, Cristian P.; Schoenenberger, Joan Antoni; Encinas Martín, Mario; Garí Marsol, Eloi; Matias-Guiu, Xavier; Dolcet Roca, Xavier (Wiley, 2017-04-28)
      PTEN is one of the most frequently mutated genes in human cancers. The frequency of PTEN alterations is particularly high in endometrial carcinomas. Loss of PTEN leads to dysregulation of cell division, and promotes the ...