Now showing items 1-6 of 6

    • Depletion of oxidative and endoplasmic reticulum stress regulators in Pick disease 

      Ilieva, Ekaterina V.; Naudí i Farré, Alba; Kichev, Anton Vladimirov; Ferrer, Isidre; Pamplona Gras, Reinald; Portero Otín, Manuel (Elsevier, 2010)
      Both oxidative and endoplasmic reticulum (ER) stress is associated with multiple neurodegenerative, age-related diseases. The rare disorder Pick disease (PiD) shares some pathological hallmarks of other neurodegenerative ...
    • Dietary protein restriction decreases oxidative protein damage, peroxidizability index, and mitochondrial complex I content in rat liver 

      Ayala Jové, Ma. Victoria (Maria Victoria); Naudí i Farré, Alba; Sanz, Alberto; Caro, Pilar; Portero Otín, Manuel; Barja, Gustavo; Pamplona Gras, Reinald (Oxford University Press, 2007)
      Caloric restriction (CR) decreases oxidative damage, which contributes to the slowing of aging rate. It is not known if such decreases are due to calories themselves or specific dietary components. In this work, the ...
    • Effect of 8.5% and 25% caloric restriction on mitochondrial free radical production and oxidative stress in rat liver 

      Gómez, José; Caro, Pilar; Naudí i Farré, Alba; Portero Otín, Manuel; Pamplona Gras, Reinald; Barja, Gustavo (Springer Verlag, 2007)
      Previous studies have consistently shown that 40% caloric restriction (CR) decreases the rate of mitochondrial ROS production and steady-state levels of markers of oxidative damage to macromolecules including mitochondrial ...
    • Mitochondrial Dysfunction and Oxidative and Endoplasmic Reticulum Stress in Argyrophilic Grain Disease 

      Ilieva, Ekaterina V.; Kichev, Anton Vladimirov; Naudí i Farré, Alba; Ferrer, Isidre; Pamplona Gras, Reinald; Portero Otín, Manuel (Oxford University Press, 2011)
      Argyrophilic grain disease (AGD) is characterized by the accumulation of hyperphosphorylated 4R tau in dendritic varicosities (i.e."grains") in neurons and pretangles in certain areas of the cerebral cortex and other brain ...
    • Plant-derived phenolics inhibit the accrual of structurally characterised protein and lipid oxidative modifications 

      Soler Cantero, Arantza; Jové Font, Mariona; Cacabelos Barral, Daniel; Boada Pallàs, Jordi; Naudí i Farré, Alba; Romero Fabregat, Mª Paz; Cassanyé, Anna; Serrano Casasola, José Carlos Enrique; Arola i Ferrer, Lluís; Valls, Josep; Bellmunt i Curcó, Josepa; Prat Corominas, Joan; Pamplona Gras, Reinald; Portero Otín, Manuel; Motilva Casado, Mª José (Public Library of Science, 2012)
      Epidemiological data suggest that plant-derived phenolics beneficial effects include an inhibition of LDL oxidation. After applying a screening method based on 2,4-dinitrophenyl hydrazine- protein carbonyl reaction to 21 ...
    • Sixty years old is the breakpoint of human frontal cortex aging 

      Cabré Cucó, Rosanna; Naudí i Farré, Alba; Dominguez Gonzalez, Mayelin; Ayala Jové, Ma. Victoria (Maria Victoria); Jové Font, Mariona; Mota Martorell, Natalia; Piñol Ripoll, Gerard; Gil Villar, M. Pilar; Rué i Monné, Montserrat; Portero Otín, Manuel; Ferrer, Isidre; Pamplona Gras, Reinald (Elsevier, 2017)
      Human brain aging is the physiological process which underlies as cause of cognitive decline in the elderly and the main risk factor for neurodegenerative diseases such as Alzheimer's disease. Human neurons are functional ...