Now showing items 1-9 of 9

    • Chemokines induce axon outgrowth downstream of Hepatocyte Growth Factor and TCF/β-catenin signaling 

      Bhardwaj, Deepshikha; Nàger Grifo, Mireia; Camats, Judith; David, Mónica Delia; Benguria, Alberto; Dopazo, Ana; Cantí Nicolás, Carles; Herreros Danés, Judit (Frontiers, 2013)
      Axon morphogenesis is a complex process regulated by a variety of secreted molecules, including morphogens and growth factors, resulting in the establishment of the neuronal circuitry. Our previous work demonstrated that ...
    • Cytoplasmic Cyclin D1 regulates glioblastoma dissemination 

      Cemeli, Tània; Guasch Vallés, Marta; Nàger Grifo, Mireia; Felip, Isidre; Cambray Carner, Serafí; Santacana Espasa, Maria; Gatius Calderó, Sònia; Pedraza González, Neus; Dolcet Roca, Xavier; Ferrezuelo, Francisco; Schuhmacher, Alberto J.; Herreros Danés, Judit; Garí Marsol, Eloi (Wiley, 2019)
      Glioblastoma (GBM) is a highly invasive brain neoplasia with an elevated recurrence rate after surgical resection. The CyclinD1 (Ccnd1)/Cdk4-RB1 axis is frequently altered in GBM, leading to over-proliferation by RB1 ...
    • FAK inhibition induces glioblastoma cell senescence-like state through p62 and p27 

      Alza, Lía; Nàger Grifo, Mireia; Visa Pretel, Anna; Cantí Nicolás, Carles; Herreros Danés, Judit (MDPI, 2020-04-27)
      Focal adhesion kinase (FAK) is a central component of focal adhesions that regulate cancer cell proliferation and migration. Here, we studied the effects of FAK inhibition in glioblastoma (GBM), a fast growing brain tumor ...
    • Histone deacetylase inhibitors promote glioma cell death by G2 checkpoint abrogation leading to mitotic catastrophe 

      Cornago Protomártir, Marta; Garcia-Alberich, C.; Blasco Angulo, Natividad; Vall-llaura Espinosa, Núria; Nàger Grifo, Mireia; Herreros Danés, Judit; Comella i Carnicé, Joan Xavier; Sanchis, Daniel; Llovera i Tomàs, Marta (Nature Publishing Group, 2014-10-02)
      Glioblastoma multiforme is resistant to conventional anti-tumoral treatments due to its infiltrative nature and capability of relapse; therefore, research efforts focus on characterizing gliomagenesis and identifying ...
    • Inhibition of WNT-CTNNB1 signaling upregulates SQSTM1 and sensitizes glioblastoma cells to autophagy blockers 

      Nàger Grifo, Mireia; Crespí Sallán, Marta; Visa Pretel, Anna; Pushparaj, Charumathi; Santacana Espasa, Maria; Macià Armengol, Anna; Yeramian Hakim, Andree; Cantí Nicolás, Carles; Herreros Danés, Judit (Taylor & Francis, 2018-01-09)
      WNT-CTNN1B signaling promotes cancer cell proliferation and stemness. Furthermore, recent evidence indicates that macroautophagy/autophagy regulates WNT signaling. Here we investigated the impact of inhibiting WNT signaling ...
    • Phosphorylated Tyr142 β-catenin localizes to centrosomes and is regulated by Syk 

      Bhardwaj, Deepshikha; Nàger Grifo, Mireia; Visa Pretel, Anna; Crespí Sallán, Marta; Coopman, PJ; Cantí Nicolás, Carles; Herreros Danés, Judit (Willey, 2018-04-01)
      β-catenin is a central component of adherent junctions and a key effector of canonical Wnt signalling, in which dephosphorylated Ser/Thr β-catenin regulates gene transcription. β-catenin phosphorylation at Tyr142 (PTyr142 ...
    • T-type Ca2+ Channels: T for Targetable 

      Crespí Sallán, Marta; Visa, Anna; Shaikh, Soni; Nàger Grifo, Mireia; Herreros Danés, Judit; Cantí Nicolás, Carles (Taylor & Francis, 2018-01-17)
      In the last decade TTCC have been unveiled as key regulators of cancer cells biology and thus have been proposed as chemotherapeutic targets. Indeed in vitro and in vivo studies indicate that TTCC pharmacological blockers ...
    • Voltage-gated calcium channel blockers deregulate macroautophagy in cardiomyocytes 

      Pushparaj, Charumathi; Das, Arindam; Purroy, Rosa; Nàger Grifo, Mireia; Herreros Danés, Judit; Pamplona Gras, Reinald; Cantí Nicolás, Carles (Elsevier, 2015)
      Voltage-gated calcium channel blockers are widely used for the management of cardiovascular diseases, however little is known about their effects on cardiac cells in vitro. We challenged neonatal ventricular cardiomyocytes ...
    • β-catenin signalling in Glioblastoma multiforme and Glioma-initiating cells 

      Nàger Grifo, Mireia; Bhardwaj, Deepshikha; Cantí Nicolás, Carles; Medina Hernández, Loreta Mª; Nogués Bara, Pere; Herreros Danés, Judit (Hindawi Publishing Corporation, 2012)
      Glioblastoma multiforme (GBM) is a commonly occurring brain tumor with a poor prognosis. GBM can develop both “de novo” or evolve from a previous astrocytoma and is characterized by high proliferation and infiltration into ...