Now showing items 1-5 of 5

    • Calcium channel expression and applicability as targeted therapies in melanoma 

      Macià Armengol, Anna; Herreros Danés, Judit; Martí Laborda, Rosa Ma.; Cantí Nicolás, Carles (Hindawi Publishing Corporation, 2015)
      The remodeling of Ca2+ signaling is a common finding in cancer pathophysiology serving the purpose of facilitating proliferation, migration, or survival of cancer cells subjected to stressful conditions. One particular ...
    • Immunohistochemical analysis of T-type calcium channels in acquired melanocytic nevi and melanoma 

      Maiques Carlos, Oscar; Macià Armengol, Anna; Moreno, Sara; Barceló Gómez, Carla; Santacana Espasa, Maria; Veà Jódar, Àlvar; Herreros Danés, Judit; Gatius Calderó, Sònia; Ortega Izquierdo, Maria Eugenia; Valls Marsal, Joan; Chen, Bo-Juen; Llovet Navàs, David; Matias-Guiu, Xavier; Cantí Nicolás, Carles; Martí Laborda, Rosa Ma. (Wiley Online Library, 2016-10-08)
      BACKGROUND AND OBJECTIVES: Cutaneous malignant melanoma arises from transformed melanocytes de novo or from congenital or acquired melanocytic nevi. We have recently reported that T-type Ca2+ channels (TTCs) are upregulated ...
    • Inhibition of WNT-CTNNB1 signaling upregulates SQSTM1 and sensitizes glioblastoma cells to autophagy blockers 

      Nàger Grifo, Mireia; Crespí Sallán, Marta; Visa Pretel, Anna; Pushparaj, Charumathi; Santacana Espasa, Maria; Macià Armengol, Anna; Yeramian Hakim, Andree; Cantí Nicolás, Carles; Herreros Danés, Judit (Taylor & Francis, 2018-01-09)
      WNT-CTNN1B signaling promotes cancer cell proliferation and stemness. Furthermore, recent evidence indicates that macroautophagy/autophagy regulates WNT signaling. Here we investigated the impact of inhibiting WNT signaling ...
    • Sprouty1 haploinsufficiency accelerates pheochromocytoma development in Pten+/- mice 

      Vaquero, Marta; Macià Armengol, Anna; Anerillas Aljama, Diego; Velasco Sánchez, Ana; Matias-Guiu, Xavier; Ribera i Calvet, Joan; Encinas Martín, Mario (Society for Endocrinology, 2016-02-01)
      Pheochromocytomas (PCCs) are rare catecholamine-secreting tumors arising from the chromaffin cells in the adrenal medulla. Closely related paragangliomas share developmental origin but arise extra-adrenally, in the paraganglia ...
    • T-type calcium channels drive migration/invasion in BRAFV600E melanoma cells through Snail1 

      Maiques Carlos, Oscar; Barceló Gómez, Carla; Panosa, Anaïs; Pijuan Marquilles, Jordi; Orgaz, Jose L.; Rodríguez Hernández, Irene; Matas Nadal, Clara; Tell, Gemma; Vilella, Ramón; Fabra, Angels; Puig, Susana; Sanz Moreno, Victoria; Matias-Guiu, Xavier; Cantí Nicolás, Carles; Herreros Danés, Judit; Martí Laborda, Rosa Ma.; Macià Armengol, Anna (Wiley, 2018)
      Melanoma is a malignant tumor derived from melanocytes. Once disseminated, it is usually highly resistant to chemotherapy and is associated with poor prognosis. We have recently reported that T-type calcium channels (TTCCs) ...