Now showing items 1-8 of 8

    • 1,25-Dihydroxyvitamin D3 regulates VEGF production through a vitamin D response element in the VEGF promoter 

      Cardús i Figueras, Anna; Panizo García, Sara; Encinas Martín, Mario; Dolcet Roca, Xavier; Gallego, Carme; Aldea, Martí; Fernandez, Elvira; Valdivielso Revilla, José Manuel (Elsevier, 2009)
      In previous studies we have demonstrated that the active form of vitamin D (1,25(OH)2D3) increases vascular endothelial growth factor (VEGF) expression and release in vascular smooth muscle cells (VSMC) in vitro. However, ...
    • Cyclin Cln3 is retained at the ER and released by the J chaperone Ydj1 in late G1 to trigger cell cycle entry 

      Vergés, Emili; Colomina i Gabarrella, Neus; Garí Marsol, Eloi; Gallego, Carme; Aldea, Martí (Elsevier, 2007)
      G1 cyclin Cln3 plays a key role in linking cell growth and proliferation in budding yeast. It is generally assumed that Cln3, which is present throughout G1, accumulates passively in the nucleus until a threshold is reached ...
    • Efecto diferencial de los análogos de la vitamina D en la proliferación de células de músculo liso vascular 

      Cardús i Figueras, Anna; Gallego, Carme; Muray, S.; Marco, M. P.; Parisi Capdevila, Eva; Aldea, Martí; Fernández i Giráldez, Elvira (Sociedad Espanola de Nefrologia, 2003)
      Existen datos experimentales contradictorios respecto al comportamiento de las células de músculo liso vascular (CMLV) expuestas al calcitriol. Determinar el efecto del calcitriol y de sus análogos a nivel vascular tiene ...
    • Protein Kinase KIS Localizes to RNA Granules and Enhances Local Translation 

      Cambray Carner, Serafí; Pedraza González, Neus; Rafel i Borrell, Marta; Garí Marsol, Eloi; Aldea, Martí; Gallego, Carme (American Society for Microbiology, 2009)
      The regulation of mRNA transport is a fundamental process for cytoplasmic sorting of transcripts and spatially controlled translational derepression once properly localized. There is growing evidence that translation is ...
    • Recruitment of Staufen2 Enhances Dendritic Localization of an Intron-Containing CaMKIIα mRNA 

      Ortiz, Raul; Georgieva, Maya V.; Gutiérrez, Sara; Pedraza González, Neus; Fernández-Moya, Sandra M.; Gallego, Carme (Elsevier, 2017)
      Regulation of mRNA localization is a conserved cellular process observed in many types of cells and organisms. Asymmetrical mRNA distribution plays a particularly important role in the nervous system, where local translation ...
    • The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation 

      Ferrezuelo, Francisco; Colomina i Gabarrella, Neus; Palmisano, Alida; Garí Marsol, Eloi; Gallego, Carme; Csikász-Nagy, Attila; Aldea, Martí (Nature, 2012)
      Budding yeast cells are assumed to trigger Start and enter the cell cycle only after they attain a critical size set by external conditions. However, arguing against deterministic models of cell size control, cell volume ...
    • The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-κB signaling 

      Solé Serra, Carme; Dolcet Roca, Xavier; Segura Ginard, Miguel Francisco; Gutierrez, Humberto; Diaz Meco, Maria Teresa; Gozzelino, Raffaella; Sanchis, Daniel; Bayascas Ramírez, José Ramón; Gallego, Carme; Moscat, Jorge; Davies, Alun M.; Comella i Carnicé, Joan Xavier (Rockefeller University Press, 2004)
      Fas apoptosis inhibitory molecule (FAIM) is a protein identified as an antagonist of Fas-induced cell death. We show that FAIM overexpression fails to rescue neurons from trophic factor deprivation, but exerts a marked ...
    • Whi3 binds the mRNA of the G(1) cyclin CLN3 to modulate cell fate in budding yeast 

      Garí Marsol, Eloi; Volpe, Tom; Wang, Hongyin; Gallego, Carme; Futcher, Bruce; Aldea, Martí (Cold Spring Harbor Laboratory Press, 2001)
      Eukaryotic cells commit in G1 to a new mitotic cycle or to diverse differentiation processes. Here we show that Whi3 is a negative regulator of Cln3, a G1 cyclin that promotes transcription of many genes to trigger the ...