Browsing Articles publicats (Ciències Mèdiques Bàsiques) by Title
Now showing items 494-513 of 548
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The oxidative stress response in yeast cells involves changes in the stability of Aft1 regulon mRNAs
(John Wiley & SonsBlackwell Publishing, 2011)Saccharomyces cerevisiae can import iron through a high-affinity system consisting of the Ftr1/Fet3- mediated reductive pathway and the siderophoremediated non-reductive one. Expression of components of the high-affinity ... -
The PacC-family protein Rim101 prevents selenite toxicity in Saccharomyces cerevisiae by controlling vacuolar acidification
(Elsevier, 2014)Saccharomyces cerevisiae Rim101 is a member of the fungal PacC family of transcription factors involved in the response to alkaline pH stress. Further studies have also implicated Rim101 in the responses to other stresses, ... -
The plasma membrane-enriched fraction proteome response during adaptation to hydrogen peroxide in Saccharomyces cerevisiae
(Informa Healthcare, 2012)In Saccharomyces cerevisiae, adaptation to hydrogen peroxide (H2O2) decreases plasma membrane permeability to H2O2, changes its lipid composition and reorganizes ergosterol-rich microdomains by a still unknown mechanism. ... -
The Power-law formalism as a tool for modeling hormonal systems
(Hindawi, 1999)Modeling a hormone system requires a number of simplifying assumptions. Often, the final conceptual model incorporates a number of aggregated processes that have no correspondence with a single enzyme-catalyzed ... -
The production of reactive oxygen species is a universal action mechanism of Amphotericin B against pathogenic yeasts and contributes to the fungicidal effect of this drug
(American Society for Microbiology, 2014)Amphotericin B (AMB) is an antifungal drug that binds to ergosterol and forms pores at the cell membrane, causing the loss of ions. In addition, AMB induces the accumulation of reactive oxygen species (ROS), and although ... -
The relative importance of transcription rate, cryptic transcription and mRNA stability on shaping stress responses in yeast
(Taylor & FrancisLandes Bioscience, 2012)It has been recently stated that stress-responding genes in yeast are enriched in cryptic transcripts and that this is the cause of the differences observed between mRNA amount and RNA polymerase occupancy profiles. Other ... -
The rise of T-type channels in melanoma progression and chemotherapeutic resistance
(Elsevier, 2020-04-07)Hyperactivation of the Mitogen Activated Protein Kinase (MAPK) pathway is prevalent in melanoma, principally due to mutations in the B-Raf and NRas genes. MAPK inhibitors are effective only shortterm, and recurrence occurs ... -
The role of morbid obesity in the promotion of metabolic disruptions and non-alcoholic steatohepatitis by Helicobacter Pylori
(Public Library of Science, 2016)Helicobacter pylory (HP) infection has been associated to an increased rate of type 2 diabetes (T2D) and liver disease through its effect on insulin resistance and systemic inflammation. However, results are inconstant ... -
The single AmphiTrk receptor highlights increased complexity of neurotrophin signalling in vertebrates and suggests an early role in developing sensory neuroepidermal cells
(Company of Biologists Ltd., 2005-02)Neurotrophins (Nt) and their tyrosine kinase Trk receptors play an essential role in the development and maintenance of the complex vertebrate nervous system. Invertebrate genome sequencing projects have suggested that the ... -
The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages
(Oxford University Press, 2010)Mitotic chromosome segregation requires the removal of physical connections between sister chromatids. In addition to cohesin and topological entrapments, sister chromatid separation can be prevented by the presence of ... -
The transcriptional network activated by Cln3 cyclin at the G1-to-S transition of the yeast cell cycle
(BioMed Central, 2010)Background: The G1-to-S transition of the cell cycle in the yeast Saccharomyces cerevisiae involves an extensive transcriptional program driven by transcription factors SBF (Swi4-Swi6) and MBF (Mbp1-Swi6). Activation of ... -
The use of treatment modality specific analysis according to Selwood in epidemiological studies
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The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors
(Public Library of Science, 2009)In order to identify genetic factors related to thyroid cancer susceptibility, we adopted a candidate gene approach. We studied tag- and putative functional SNPs in genes involved in thyroid cell differentiation and ... -
The yeast Aft2 transcription factor determines selenite toxicity by controlling the low affinity phosphate transport system
(Scientific Reports, 2016)The yeast Saccharomyces cerevisiae is employed as a model to study the cellular mechanisms of toxicity and defense against selenite, the most frequent environmental selenium form. We show that yeast cells lacking Aft2, a ... -
Thyroid hormones directly activate the expression of the human and mouse uncoupling protein-3 genes through a thyroid response element in the proximal promoter region
(Portland Press, 2005)The transcription of the human UCP3 (uncoupling protein-3) gene in skeletal muscle is tightly regulated by metabolic signals related to fatty acid availability. However, changes in thyroid status also modulate UCP3 gene ... -
Toll Like Receptor 2 promoter -196 to -174 deletion affects CD4 levels along HIV infection progression
(Infectious Diseases Society of AmericaOxford University Press, 2020-06-09)TLR2 plays a key role in innate immune response recognizing molecular patterns expressed by pathogens. rs111200466 is a TLR2 promoter Insertion/Deletion polymorphism with contradictory data about its role in HIV-1 infection. ... -
Tools for kinetic modeling of biochemical networks
(Nature Publishing Group, 2006)The number of software packages for kinetic modeling of biochemical networks continues to grow. Although most packages share a common core of functionality, the specific capabilities and user interfaces of different ... -
Tor1, Sch9 and PKA downregulation in quiescence rely on Mtl1 to preserve mitochondrial integrity and cell survival
(John Wiley & Sons, 2015-07-22)Here we show that Mtl1, member of the cell wall integrity pathway of Saccharomyces cerevisiae, plays a positive role in chronological life span (CLS). The absence of Mtl1 shortens CLS and causes impairment in the mitochondrial ... -
Transcription of ribosomal genes can cause nondisjunction
(The Rockefeller University Press, 2006)Mitotic disjunction of the repetitive ribosomal DNA (rDNA) involves specialized segregation mechanisms dependent on the conserved phosphatase Cdc14. The reason behind this requirement is unknown. We show that rDNA ... -
Transcriptomic and proteomic insights of the wine yeast biomass propagation process
(Oxford University Press, 2010)Transcriptome and proteome profiles have been established for the commercial wine yeast strain T73 during an important industrial process: yeast biomass propagation. The data from both analyses reveal that the metabolic ...