Now showing items 377-396 of 561

    • Phosphorylated Tyr142 β-catenin localizes to centrosomes and is regulated by Syk 

      Bhardwaj, Deepshikha; Nàger Grifo, Mireia; Visa Pretel, Anna; Crespí Sallán, Marta; Coopman, PJ; Cantí Nicolás, Carles; Herreros Danés, Judit (Willey, 2018-04-01)
      β-catenin is a central component of adherent junctions and a key effector of canonical Wnt signalling, in which dephosphorylated Ser/Thr β-catenin regulates gene transcription. β-catenin phosphorylation at Tyr142 (PTyr142 ...
    • Phosphorylation of Hsl1 by Hog1 leads to a G2 arrest essential for cell survival at high osmolarity 

      Clotet Bellmunt, Josep; Escoté, Xavier; Àngel Adrover, Miquel; Yaakov, Gilad; Garí Marsol, Eloi; Aldea, Martí; de Nadal, Eulàlia; Posas, Francesc (EMBOPress, 2006)
      Control of cell cycle progression by stress-activated protein kinases (SAPKs) is essential for cell adaptation to extracellular stimuli. Exposure of yeast to osmostress leads to activation of the Hog1 SAPK, which controls ...
    • Physical Activity Behavior, Aerobic Fitness and Quality of Life in School-Age Children 

      Serra Payà, Noemí; Ensenyat Solé, Assumpta; Serra Paya, Pau; Blanco Nespereira, Alfonso (Elsevier, 2015)
      The aim of this article is to assess the differences in sedentary and physical activity behavior, physical fitness and quality of lifein school-age children according to their adiposity state (BMI-SD= Body Mass Index ...
    • Physical interaction between the MAPK Slt2 of the PKC1-MAPK pathway and Grx3/Grx4 glutaredoxins is required for the oxidative stress response in budding yeast 

      Pujol Carrión, Núria; Torre Ruiz, M. A. de la (Elsevier, 2017)
      This study demonstrates that both monothiol glutaredoxins Grx3 and Grx4 physically interact with the MAPK Slt2 forming a complex involved in the cellular response to oxidative stress. The simultaneous absence of Grx3 and ...
    • Pkc1 and the upstream elements of the cell integrity pathway in Saccharomyces cerevisiae, Rom2 and Mtl1, are required for cellular responses to oxidative stress 

      Vilella Mitjana, Felipe; Herrero Perpiñán, Enrique; Torres Rosell, Jordi; Torre Ruiz, M. A. de la (The American Society for Biochemistry and Molecular Biology, 2005)
      In this study we analyze the participation of the PKC1-MAPK cell integrity pathway in cellular re- sponses to oxidative stress in Saccharomyces cerevisiae. Evidence is presented demonstrating that only Pkc1 and the ...
    • Plant-derived phenolics inhibit the accrual of structurally characterised protein and lipid oxidative modifications 

      Soler Cantero, Arantza; Jové Font, Mariona; Cacabelos Barral, Daniel; Boada Pallàs, Jordi; Naudí i Farré, Alba; Romero Fabregat, Mª Paz; Cassanyé, Anna; Serrano Casasola, José Carlos Enrique; Arola i Ferrer, Lluís; Valls, Josep; Bellmunt i Curcó, Josepa; Prat Corominas, Joan; Pamplona Gras, Reinald; Portero Otín, Manuel; Motilva Casado, Mª José (Public Library of Science, 2012)
      Epidemiological data suggest that plant-derived phenolics beneficial effects include an inhibition of LDL oxidation. After applying a screening method based on 2,4-dinitrophenyl hydrazine- protein carbonyl reaction to 21 ...
    • Plasma profiling reveals a blood-based metabolic fingerprint of obstructive sleep apnea 

      Pinilla, Lucía; Benítez, Iván; Santamaría Martos, Fernando; Targa, Adriano; Moncusí Moix, Anna; Dalmases, Mireia; Minguez Roure, Olga; Aguilà, Maria; Jové Font, Mariona; Sol, Joaquim; Pamplona Gras, Reinald; Barbé Illa, Ferran; Sánchez de la Torre, Manuel (Elsevier, 2022)
      Introduction: Obstructive sleep apnea (OSA) is a chronic, heterogeneous and multicomponent disorder with associated cardiovascular and metabolic alterations. Despite being the most common sleep-disordered breathing, it ...
    • Pleiotropic analysis of lung cancer and blood triglycerides 

      Zuber, Verena; Marconett, Crystal N.; Shi, Jianxin; Hua, Xing; Wheeler, William; Yang, Chenchen; Song, Lei; Dale, Anders M.; Laplana Lafaja, Marina; Risch, Angela; Witoelar, Aree; Thompson, Wesley K.; Schork, Andrew J.; Bettella, Francesco; Wang, Yunpeng; Djurovic, Srdjan; Zhou, Beiyun; Borok, Zea; van der Heijden, Henricus F. M.; Graaf, Jacqueline de; Swinkels, Dorine; Aben, Katja K.; McKay, James D.; Hung, Rayjean J.; Bikeböller, Heike; Stevens, Victoria L.; Albanes, Demetrius; Caporaso, Neil E.; Han, Younghun; Wei, Yongyue; Panadero, Maria Ángeles; Mayordomo, José I.; Christiani, David C.; Kiemeney, Lambertus; Andreassen, O. A.; Houlston, Richard; Amos, Christopher I.; Chatterjee, Nilanjan; Laird-Offringa, Ite A.; Mills, Ian G.; Landi, Maria Teresa (Oxford University Press, 2016)
      Epidemiologically related traits may share genetic risk factors, and pleiotropic analysis could identify individual loci associated with these traits. Because of their shared epidemiological associations, we conducted ...
    • Plurality of opinion, scientific discourse and pseudoscience: an in depth analysis of the Séralini et al. study claiming that Roundup™ Ready corn or the herbicide Roundup™ cause cancer in rats 

      Arjó Pont, Gemma; Portero Otín, Manuel; Piñol Felis, Carme; Viñas Salas, Joan; Matias-Guiu, Xavier; Capell Capell, Teresa; Bartholomaeus, Andrew; Parrot, Wayne; Christou, Paul (Springer Verlag, 2013)
      A recent paper published in the journal Food and Chemical Toxicology presents the results of a long-term toxicity study related to a widely-used commercial herbicide (RoundupTM) and a Rounduptolerant genetically modified ...
    • Polyphosphate is a key factor for cell survival after DNA damage in eukaryotic cells 

      Bru, Samuel; Samper Martín, Bàrbara; Quandt, Eva; Hernández Ortega, Sara; Martínez Laínez, Joan M; Garí Marsol, Eloi; Rafel i Borrell, Marta; Torres Torronteras, Javier; Martí, Ramón; Ribeiro, Mariana; Jiménez, Javier; Clotet, Josep (Elsevier, 2017-08-08)
      Cells require extra amounts of dNTPs to repair DNA after damage. Polyphosphate (polyP) is an evolutionary conserved linear polymer of up to several hundred inorganic phosphate (Pi) residues that is involved in many functions, ...
    • Polypyrimidine tract binding proteins (PTB) regulate the expression of apoptotic genes and susceptibility to caspase-dependent apoptosis in differentiating cardiomyocytes 

      Zhang, Jisheng; Bahi i Pla, Núria; Comella i Carnicé, Joan Xavier; Sanchis, Daniel (Nature Publishing Group, 2009)
      Cardiac morphologic abnormalities in mice deficient for key regulators of the caspase-dependent signaling underscored its role in heart development. However, the mechanisms regulating apoptotic gene expression in the ...
    • Poorer Quality of Life and Treatment Satisfaction is Associated with Diabetic Retinopathy in Patients with Type 1 Diabetes without Other Advanced Late Complications 

      Granado Casas, Minerva; Castelblanco Echavarría, Esmeralda; Ramírez-Morros, Anna; Martín, Mariona; Alcubierre Calvo, Núria; Martínez Alonso, Montserrat; Valldeperas, Xavier; Traveset Maeso, Alicia; Rubinat, Esther; Lucas-Martin, Ana; Hernández García, Marta; Alonso, Núria; Mauricio Puente, Dídac (MDPI, 2019-03-18)
      Diabetic retinopathy (DR) may potentially cause vision loss and affect the patient's quality of life (QoL) and treatment satisfaction (TS). Using specific tools, we aimed to assess the impact of DR and clinical factors on ...
    • PPAR gamma agonist leriglitazone improves frataxin-loss impairments in cellular and animal models of Friedreich Ataxia 

      Rodríguez-Pascau, Laura; Britti, Elena; Calap Quintana, Pablo; Na Dong, Yi; Vergara, Cristina; Delaspre, Fabien; Medina Carbonero, Marta; Tamarit Sumalla, Jordi; Pallardó, Federico V.; Gonzalez Cabo, Pilar; Ros Salvador, Joaquim; Lynch, David R.; Martinell, Marc; Pizcueta, Pilar (Elsevier, 2021)
      Friedreich ataxia (FRDA), the most common autosomal recessive ataxia, is characterized by degeneration of the large sensory neurons and spinocerebellar tracts, cardiomyopathy, and increased incidence in diabetes. The ...
    • Preclinical carotid atherosclerosis in patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes and classical type 1 diabetes 

      Hernández García, Marta; López Cano, Carolina; Real, Jordi; Valls Marsal, Joan; Ortega, Emilio; Vázquez, Federico; Rubinat, Esther; Granado Casas, Minerva; Alonso, Núria; Molí, Teresa; Betriu i Bars, M. Àngels; Lecube Torelló, Albert; Fernández i Giráldez, Elvira; David Leslie, Richard; Mauricio Puente, Dídac (BioMed Central, 2017)
      LADA is probably the most prevalent form of autoimmune diabetes. Nevertheless, there are few data about cardiovascular disease in this group of patients. The aim of this study was to investigate the frequency of carotid ...
    • Predictive Reconstruction of the Mitochondrial Iron-Sulfur Cluster Assembly Metabolism. II. Role of Glutaredoxin Grx5 

      Alves, Rui; Herrero Perpiñán, Enrique; Sorribas Tello, Albert (John Wiley & Sons, 2004)
      Grx5 is a Saccharomyces cerevi- siae glutaredoxin involved in iron-sulfur cluster (FeSC) biogenesis. Previous work suggests that Grx5 is involved in regulating protein cysteine glutathio- nylation, prompting several ...
    • Predictors of Subclinical Atheromatosis Progression over 2 Years in Patients with Different Stages of CKD 

      Gracia, Marta; Betriu i Bars, M. Àngels; Martínez Alonso, Montserrat; Arroyo, David; Abajo, María; Fernández i Giráldez, Elvira; Valdivielso Revilla, José Manuel (American Society of Nephrology, 2016-02)
      Background and objectives Ultrasonographic detection of subclinical atheromatosis is a noninvasive method predicting cardiovascular events. Risk factors predicting atheromatosis progression in CKD are unknown. Predictors ...
    • Preliminary Results of a Screening Programme for Chlamydia in an Asymptomatic Young Population in Spain 

      Yuguero Torres, Oriol; Fernández Armenteros, José Manuel; Vilela, Álvaro; Aramburu, Jesus; Laín, Raquel; Godoy i García, Pere (Frontiers Media, 2021)
      Introduction: Chlamydia trachomatis (CT) infection has increased in recent years, reaching 127 million cases in 2016. Possible complications, especially among women, require intervention for early detection of the ...
    • Premalignant SOX2 overexpression in the fallopian tubes of ovarian cancer patients: discovery and validation studies 

      Hellner, Karin; Miranda, Fabrizio; Fotso Chedom, Donatien; Herrero Gonzalez, Sandra; Hayden, Daniel M.; Tearle, Rick; Artibani, Mara; KaramiNejadRanjbar, Mohammad; Williams, Ruth; Gaitskell, Kezia; Elorbany, Samar; Xu, Ruoyan; Laios, Alex; Buiga, Petronela; Ahmed, Karim; Dhar, Sunanda; Yu Zhang, Rebecca; Campo, Leticia; Myers, Kevin A.; Lozano, María; Ruiz Miró, Maria; Gatius Calderó, Sònia; Mota, Alba; Moreno Bueno, Gema; Matias-Guiu, Xavier; Benítez, Javier; Witty, Lorna; McVean, Gil; Leedham, Simon; Tomlinson, Ian; Drmanac, Radoje; Cazier, Jean Baptiste; Klein, Robert; Dunne, Kevin; Bast Jr, Robert C.; Kennedy, Stephen H.; Hassan, Bassim; Lise, Stefano; Garcia, María José; Peters, Brock A.; Yau, Christopher; Sauka-Spengler, Tatjana; Ashour Ahmed, Ahmed (Elsevier, 2016)
      Current screening methods for ovarian cancer can only detect advanced disease. Earlier detection has proved difficult because the molecular precursors involved in the natural history of the disease are unknown. To identify ...
    • Presenilin/γ-secretase-dependent EphA3 processing mediates axon elongation through non-muscle myosin IIA 

      Javier-Torrent, Míriam; Marco, Sergio; Rocandio Durán, Daniel; Pons-Vizcarra, Maria; Janes, Peter W; Lackmann, Martin; Egea Navarro, Joaquim; Saura, Carlos A (eLife Sciences Publications, 2019)
      EphA/ephrin signaling regulates axon growth and guidance of neurons, but whether this process occurs also independently of ephrins is unclear. We show that presenilin-1 (PS1)/γ-secretase is required for axon growth in the ...
    • Prevention of Ventilator-Associated Pneumonia: The Multimodal Approach of the Spanish ICU “Pneumonia Zero” Program 

      Álvarez Lerma, Francisco; Palomar Martínez, Mercedes; Sánchez García, Miguel; Martínez Alonso, Montserrat; Álvarez Rodríguez, Joaquín; Lorente, Leonardo; Arias Rivera, Susana; García, Rosa; Gordo, Federico; Añón, José M.; Jam Gatell, M. Rosa; Vázquez Calatayud, Mónica; Agra varela, Yolanda (Society of Critical Care Medicine; Wolters Kluwer Health, 2018-02)
      Objectives: The “Pneumonia Zero” project is a nationwide multimodal intervention based on the simultaneous implementation of a comprehensive evidence-based bundle measures to prevent ventilator-associated pneumonia in ...