Now showing items 337-356 of 560

    • Molecular Basis of Tumor Heterogeneity in Endometrial Carcinosarcoma 

      Leskelä, Susanna; Pérez-Mies, Belén; Rosa-Rosa, Juan Manuel; Cristobal, Eva; Biscuola, Michele; Palacios-Berraquero, María L.; Ong, SuFey; Matias-Guiu, Xavier; Palacios, José (MDPI, 2019)
      Endometrial carcinosarcoma (ECS) represents one of the most extreme examples of tumor heterogeneity among human cancers. ECS is a clinically aggressive, high-grade, metaplastic carcinoma. At the morphological level, ...
    • Molecular profiling of circulating tumor cells links plasticity to the metastatic process in endometrial cancer 

      Alonso-Alconada, Lorena; Muinelo-Romay, Laura; Madissoo, Kadri; Díaz-López, Antonio; Krakstad, Camilla; Trovik, Jone; Wik, Elisabeth; Hapangama, Dharani; Coenegrachts, Lieve; Cano, Amparo; Gil-Moreno, Antonio; Chiva, Luís; Cueva, Juan; Vieito, María; Ortega Izquierdo, Maria Eugenia; Mariscal, Javier; Colás, Eva; Castellví, Josep; Cusido, Maite; Dolcet Roca, Xavier; Nijman, Hans W.; Bosse, Tjalling; Green, John A.; Romano, Andrea; Reventós, Jaume; López-López, Rafael; Salvesen, Helga B.; Amant, Frederic; Matias-Guiu, Xavier; Moreno-Bueno, Gema; Abal, Miguel (Biomed Central, 2014)
      Background: About 20% of patients diagnosed with endometrial cancer (EC) are considered high-risk with unfavorable prognosis. In the framework of the European Network for Individualized Treatment in EC (ENITEC), we ...
    • Molecular staging of lymph node-negative colon carcinomas by one-step nucleic acid amplification (OSNA) results in upstaging of a quarter of patients in a prospective, European, multicentre study. 

      Croner, R. S.; Geppert, C. I.; Bader, F. G.; Nitsche, U.; Späth, C.; Rosenberg, R.; Zettl, A.; Matias-Guiu, Xavier; Tarragona Foradada, Jordi; Güller, U.; Stürzl, M.; Zuber, M. (Cancer Research, 2014)
      Background: Current histopathological staging procedures in colon carcinomas depend on midline division of the lymph nodes with one section of haematoxylin & eosin (H&E) staining only. By this method, tumour deposits outside ...
    • Molecularly determined total tumour load in lymph nodes of stage I–II colon cancer patients correlates with high-risk factors. A multicentre prospective study 

      Aldecoa, Iban; Atares, Begoña; Tarragona Foradada, Jordi; Bernet, Laia; Sardon, Jose Domingo; Pereda, Teresa; Villar, Carlos; Mendez, M. Carmen; Gonzalez-Obeso, Elvira; Elorriaga, Kepa; Lopez Alonso, Guadalupe; Zamora, Javier; Planell, Nuria; Palacios, José; Castells, Antoni; Matias-Guiu, Xavier; Cuatrecasas, Miriam (Springer, 2016)
      Stage I–II (pN0) colorectal cancer patients are surgically treated although up to 25 % will eventually die from disease recurrence. Lymph node (LN) status is an independent prognostic factor in colorectal cancer (CRC), and ...
    • Monitoring anti-PLA2R antibody titres to predict the likelihood of spontaneous remission of membranous nephropathy 

      Jatem Escalante, Elias; Martín Conde, María Luisa; Gracia-Lavedan, Esther; Benítez, Iván; González, Jorge; Colàs Campàs, Laura; Garcia Carrasco, Alicia; Martínez Martínez, Cristina; Segarra Medrano, Alfons (European Renal Association - European Dialysis and Transplant Association (ERA-EDTA); Oxford University Press, 2021)
      Background: In anti-phospholipase A2 receptor (PLA2R) membranous nephropathy (MN) there is controversy whether spontaneous remission (SR) can be predicted using a single titre or by assessing the dynamic changes in anti-PLA2R ...
    • Monothiol glutaredoxins: a common domain for multiple functions 

      Herrero Perpiñán, Enrique; Torre Ruiz, M. A. de la (Springer, 2007)
      Monothiol glutaredoxins with the CGFS sequence at the active site are widespread among prokaryotes and eukaryotes. Two subclasses exist, those with a single glutaredoxin domain and those with a thioredoxin-like region ...
    • Mtl1 is required to activate general stress response through Tor1 and Ras2 inhibition under conditions of glucose starvation and oxidative stress 

      Petkova, Mima Ivanova; Pujol Carrión, Núria; Arroyo, Javier; Garcia-Cantalejo, J.; Torre Ruiz, M. A. de la (American Society for Biochemistry and Molecular Biology, 2010)
      Mtl1 is a member of the cell wall integrity (CWI) pathway of Saccharomyces cerevisiae, which functions as a cell wall sensor for oxidative stress. Genome-wide transcriptional analysis revealed a cluster of genes that were ...
    • Mujeres que deciden interrumpir su embarazo: ¿Cómo son percibidas por un grupo de profesionales en Colombia? 

      Laza-Vásquez, Celmira; Castiblanco Montañez, Ruth Alexandra; Urrego Mendoza, Zulma Consuelo (Centro Latino-Americano em Sexualidade e Direitos Humanos (CLAM/IMS/UERJ), 2018-04-01)
      Este artículo presenta los resultados de una investigación cualitativa, que intentó comprender la percepción de 15 médicos del servicio de Ginecobstetricia de una Institución Prestadora de Servicios de Salud (IPS) en ...
    • Multicenter Phase 2 Trial of Rituximab for Waldenström Macroglobulinemia (WM): An Eastern Cooperative Oncology Group Study (E3A98) 

      Gertz, Morie A.; Rué i Monné, Montserrat; Blood, Emily; Kaminer, Lynne S.; Vesole, David H.; Greipp, Philip R. (Taylor & Francis, 2004)
      Waldenström macroglobulinemia (WM) is a low-grade lymphoplasmacytic lymphoma that strongly expresses CD20 on the cell surface. This study was undertaken to determine the response rate of patients with untreated or ...
    • Multidimensional independent predictors of cancer-related fatigue 

      Hwang, Shirley S.; Chang, Victor T.; Kasimis, Basil; Rué i Monné, Montserrat (Elsevier, 2003)
      The purpose of this study was to identify independent predictors of clinically significant fatigue based upon a multidimensional model. A total of 180 cancer patients completed the Brief Fatigue Inventory (BFI), Functional ...
    • Multilayer OMIC data in medullary thyroid carcinoma identifies the STAT3 pathway as a potential therapeutic target in RETM918T tumors 

      Mancikova, Veronica; Montero Conde, Cristina; Perales Paton, Javier; Fernandez, Agustin F; Santacana Espasa, Maria; Jodkowska, Karolina; Inglada-Pérez, Lucía; Castelblanco Echavarría, Esmeralda; Borrego, Salud; Encinas Martín, Mario; Matias-Guiu, Xavier; Fraga, Mario; Robledo, Mercedes (American Association for Cancer Research., 2016-09-12)
      Purpose: Medullary thyroid carcinoma (MTC) is a rare disease with few genetic drivers, and the etiology specific to each known susceptibility mutation remains unknown. Exploiting multilayer genomic data, we focused our ...
    • Multilevel interactions between native and ectopic isoprenoid pathways affect global metabolism in rice 

      Pérez, Lucía; Alves, Rui; Perez‑Fons, Laura; Albacete, Alfonso; Farré Martinez, Gemma; Soto, Erika; Vilaprinyo Terré, Ester; Martínez‑Andújar, Cristina; Basallo, Oriol; Fraser, Paul D.; Medina, Vicente; Zhu, Changfu; Capell Capell, Teresa; Christou, Paul (Springer, 2022)
      MVA pathway could be circumvented by express- ing an ectopic plastidial MVA pathway that increases the accumulation of IPP and DMAPP in plastids. We therefore introduced genes encoding the plastid- targeted enzymes ...
    • Neuronal survival induced by neurotrophins requires calmodulin 

      Egea Navarro, Joaquim; Espinet Mestre, Carme; Soler i Tatché, Rosa Ma.; Dolcet Roca, Xavier; Yuste Mateos, Víctor J. (Víctor José); Encinas Martín, Mario; Iglesias Durán, Montserrat; Rocamora Ibars, Nativitat; Comella i Carnicé, Joan Xavier (Rockefeller University Press, 2001)
      It has been reported that phosphoinositide 3-kinase (PI 3-kinase) and its downstream target, protein kinase B (PKB), play a central role in the signaling of cell survival triggered by neurotrophins (NTs). In this report, ...
    • Neuroprotection by neurotrophic factors and membrane depolarization is regulated by calmodulin kinase IV 

      Pérez García, María José; Gou Fàbregas, Myriam; Pablo Llavall, Yolanda de; Llovera i Tomàs, Marta; Comella i Carnicé, Joan Xavier; Soler i Tatché, Rosa Ma. (American Society for Biochemistry and Molecular Biology, 2008)
      Neurotrophic factors promote motoneuron (MN) survival through increased intracellular calcium (Ca(2+)) and regulation of the phosphatidylinositol (PI) 3-kinase/protein kinase B (PKB) pathway by calmodulin (CaM). Activation ...
    • New approaches to the study of Antarctic lithobiontic microrganisms and their inorganic traces, and their application in the detection of life in Martian rocks 

      Ascaso, C.; Wierzchos, Jacek (Springer Verlag, 2002)
      Microbial life in the harsh conditions of Antarctica’s cold desert may be considered an analogue of potential life on early Mars. In order to explore the development and survival of this epilithic and endolithic form ...
    • NF-κB signalling regulates the growth of neural processes in the developing PNS and CNS 

      Gutierrez, Humberto; Hale, Valerie A.; Dolcet Roca, Xavier; Davies, Alun M. (Company of Biologists Ltd., 2005-04)
      The proper growth and elaboration of neural processes is essential for the establishment of a functional nervous system during development and is an integral feature of neural plasticity throughout life. Nuclear factor-kappa ...
    • Nitric oxide prevents Aft1 activation and metabolic remodeling in frataxindeficient yeast 

      Alsina Obiols, David; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (Elsevier, 2018)
      Yeast frataxin homolog (Yfh1) is the orthologue of human frataxin, a mitochondrial protein whose deficiency causes Friedreich Ataxia. Yfh1 deficiency activates Aft1, a transcription factor governing iron homeostasis in ...
    • Non-invasive imaging techniques and assessment of carotid vasa vasorum neovascularization: promises and pitfalls 

      Pereira, Tania; Betriu i Bars, M. Àngels; Alves, Rui (Elsevier, 2018)
      Carotid adventitia vasa vasorum neovascularization (VVn) is associated with the initial stages of arteriosclerosis and with the formation of unstable plaque. However, techniques to accurately quantify that neovascularization ...
    • Notch signaling pathway is activated in motoneurons of spinal muscular atrophy 

      Cardona-Rossinyol, Andrea; Garcera, Ana; Torres-Benito, Laura; Soler i Tatché, Rosa Ma.; Tabares, Lucía; Lladó, Jerònia; Olmos, Gabriel; Caraballo-Miralles, Víctor (MDPI, 2013)
      Spinal muscular atrophy (SMA) is a neurodegenerative disease produced by low levels of Survival Motor Neuron (SMN) protein that affects alpha motoneurons in the spinal cord. Notch signaling is a cell-cell communication ...
    • Novel Antioxidant Role of Alcohol Dehydrogenase E from Escherichia coli 

      Echave Lozano, Pedro; Tamarit Sumalla, Jordi; Cabiscol Català, Elisa; Ros Salvador, Joaquim (American Society for Biochemistry and Molecular Biology, 2003)
      Alcohol dehydrogenase E (AdhE) is an Fe-enzyme that, under anaerobic conditions, is involved in dissimilation of glucose. The enzyme is also present under aerobic conditions, its amount is about one-third and its activity ...