Now showing items 311-330 of 548

    • Metabolic remodeling in frataxin-deficient yeast is mediated by Cth2 and Adr1 

      Moreno Cermeño, Armando J.; Alsina Obiols, David; Cabiscol Català, Elisa; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim (Elsevier, 2013)
      Frataxin is a mitochondrial protein involved in iron metabolism whose deficiency in humans causes Friedreich ataxia. We performed transcriptomic and proteomic analyses of conditional Yeast Frataxin Homologue (Yfh1) mutants ...
    • Metabolomic and lipidomic profiling identifies the role of the RNA editing pathway in endometrial carcinogenesis 

      Altadill, Tatiana; Dowdy, Tyrone M.; Gill, Kirandeep; Reques, Armando; Menon, Smrithi S.; Moiola, Cristian P.; Lopez-Gil, Carlos; Coll, Eva; Matias-Guiu, Xavier; Cabrera, Silvia; Garcia, Angel; Reventós, Jaume; W. Byers, Stephen; Gil-Moreno, Antonio; Cheema, Amrita K.; Colás, Eva (Nature Publishing Group, 2017)
      Endometrial cancer (EC) remains the most common malignancy of the genital tract among women in developed countries. Although much research has been performed at genomic, transcriptomic and proteomic level, there is still ...
    • Metabolomics predicts neuroimaging characteristics of transient ischemic attack patients 

      Purroy Garcia, Francisco; Cambray Carner, Serafí; Mauri-Capdevila, Gerard; Jové Font, Mariona; Sanahuja Montesinos, Jordi; Farré, Joan; Benabdelhak Abbou, Ikram; Molina Seguin, Jessica; Colàs Campàs, Laura; Begué Gómez, Robert; Gil, M. Isabel; Pamplona Gras, Reinald; Portero Otín, Manuel (Elsevier, 2016)
      Background: Neuroimaging is essential for the diagnosis and prognosis of transient ischemic attack (TIA). The discovery of a plasmatic biomarker related to neuroimaging findings is of enormous interest because, despite ...
    • Metabolomics predicts stroke recurrence after transient ischemic attack 

      Jové Font, Mariona; Mauri-Capdevila, Gerard; Suárez-Luis, Idalmis; Cambray Carner, Serafí; Sanahuja Montesinos, Jordi; Quilez Martínez, Alejandro; Farré, Joan; Benabdelhak Abbou, Ikram; Pamplona Gras, Reinald; Portero Otín, Manuel; Purroy Garcia, Francisco (American Academy of Neurology, 2015)
      Objective: To discover, by using metabolomics, novel candidate biomarkers for stroke recurrence (SR) with a higher prediction power than present ones. Methods: Metabolomic analysis was performed by liquid chromatography ...
    • Metabotyping human endometrioid endometrial adenocarcinoma reveals an implication of endocannabinoid metabolism 

      Jové Font, Mariona; Gatius Calderó, Sònia; Yeramian Hakim, Andree; Portero Otín, Manuel; Eritja Sánchez, Núria; Santacana Espasa, Maria; Colás, Eva; Ruiz, M.; Pamplona Gras, Reinald; Matias-Guiu, Xavier (Impact Journals, 2016)
      Metabolomics, an essential technique in precision medicine, contributes to the molecular fingerprinting of tumours, further helping to understand their pathogenesis. In this work, using a LC-ESI-QTOF-MS/MS platform, we ...
    • Metal-catalyzed Oxidation of Fe2+ Dehydrogenases: consensus target sequence between Propanediol Oxidoreductase of Escherichia Coli and alcohol dehydrogenase I1 of Zymomonas Mobilis 

      Cabiscol Català, Elisa; Aguilar, Juan; Ros Salvador, Joaquim (American Society for Biochemistry and Molecular Biology, 1994)
      We have studied two enzymes of a newly described family of dehydrogenases with high sequence homology, 1,2-propanediol oxidoreductase of Escherichia coli and alcohol dehydrogenase II of Zymomonas mobilis. These enzymes ...
    • Metàstasis de melanoma maligne en nòduls pulmonar múltiples 

      Tarragona Foradada, Jordi; Pallarés, J.; Buetas, P.; Subirats, A.; Matias-Guiu, Xavier (Societat Catalana de Citopatologia, 2019-10)
    • Methods for and results from the study of design principles in molecular systems 

      Salvadó López, Baldiri; Karathia, Hiren; Usié Chimenos, Anabel; Vilaprinyo Terré, Ester; Omholt, Stig; Sorribas Tello, Albert; Alves, Rui (Elsevier, 2011)
      Most aspects of molecular biology can be understood in terms of biological design principles. These principles can be loosely defined as qualitative and quantitative features that emerge in evolution and recur more ...
    • Methylation alterations are not a major cause of PTTG1 missregulation 

      Hidalgo, Manuel; Galan, Jose J.; Sáez, Carmen; Ferrero, Eduardo; Castilla, Carolina; Ramirez Lorca, Reposo; Pelaez, Pablo; Ruiz, Agustín; Japón, Miguel A.; Royo Sánchez-Palencia, José Luis (BioMed Central, 2008)
      Background: On its physiological cellular context, PTTG1 controls sister chromatid segregation during mitosis. Within its crosstalk to the cellular arrest machinery, relies a checkpoint of integrity for which gained the ...
    • Mice harboring the FXN I151F pathological point mutation present decreased frataxin levels, a Friedreich ataxia-like phenotype, and mitochondrial alterations 

      Medina Carbonero, Marta; Sanz Alcázar, Arabela; Britti, Elena; Delaspre, Fabien; Cabiscol Català, Elisa; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (SpringerBirkhäuser Verlag, 2022)
      Friedreich Ataxia (FA) is a rare neuro-cardiodegenerative disease caused by mutations in the frataxin (FXN) gene. The most prevalent mutation is a GAA expansion in the first intron of the gene causing decreased frataxin ...
    • Micromorphological characterization and lithification of microbial mats from the Ebro Delta (Spain) 

      Wierzchos, Jacek; Berlanga Herranz, Mercedes; Ascaso Ciria, María del Carmen; Guerrero, Ricardo (Sociedad Española de Microbiología, 2006)
      The structural organization of microbial mats from the Ebro Delta (Spain) and their accretion and partial lithification processes were explored using scanning electron microscopy in back-scattered electron mode and ...
    • Minimization of biosynthetic costs in adaptive gene expression responses of yeast to environmental changes 

      Vilaprinyo Terré, Ester; Alves, Rui; Sorribas Tello, Albert (Public Library of Science (PLoS), 2010)
      Yeast successfully adapts to an environmental stress by altering physiology and fine-tuning metabolism. This fine-tuning is achieved through regulation of both gene expression and protein activity, and it is shaped by ...
    • Mitochondrial calcium signaling and neurodegenerative diseases 

      Britti, Elena; Delaspre, Fabien; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim (Portland Press, 2018-11-16)
      Calcium is utilised by cells in signalling and in regulating ATP production; it also contributes to cell survival and, when concentrations are unbalanced, triggers pathways for cell death. Mitochondria contribute to calcium ...
    • Mitochondrial Dysfunction and Oxidative and Endoplasmic Reticulum Stress in Argyrophilic Grain Disease 

      Ilieva, Ekaterina V.; Kichev, Anton Vladimirov; Naudí i Farré, Alba; Ferrer, Isidre; Pamplona Gras, Reinald; Portero Otín, Manuel (Oxford University Press, 2011)
      Argyrophilic grain disease (AGD) is characterized by the accumulation of hyperphosphorylated 4R tau in dendritic varicosities (i.e."grains") in neurons and pretangles in certain areas of the cerebral cortex and other brain ...
    • Mitochondrial Hsp60, resistance to oxidative stress, and the labile iron pool are closely connected in Saccharomyces cerevisiae 

      Cabiscol Català, Elisa; Bellí i Martínez, Gemma; Tamarit Sumalla, Jordi; Echave Lozano, Pedro; Herrero Perpiñán, Enrique; Ros Salvador, Joaquim (The American Society for Biochemistry and Molecular Biology, 2002)
      In the present study, we have analyzed the role of the molecular chaperone Hsp60 in protection of Saccharo- myces cerevisiae against oxidative damage. We con- structed mutant strains in which the levels of Hsp60 protein, ...
    • Mitochondrial localization of the yeast forkhead factor Hcm1 

      Rodríguez Colman, Maria José; Ros Salvador, Joaquim; Cabiscol Català, Elisa (MDPI, 2020-12)
      Hcm1 is a member of the forkhead transcription factor family involved in segregation, spindle pole dynamics, and budding in Saccharomyces cerevisiae. Our group described the role of Hcm1 in mitochondrial biogenesis and ...
    • Modelos probabilísticos de mortalidad para pacientes hospitalizados en unidades convencionales 

      Rué i Monné, Montserrat; Roqué, Marta; Solà, Judit; Macià, Marta (Elsevier España, 2001)
      FUNDAMENTO: Se ha desarrollado un instrumento de medida de la gravedad para pacientes hospitalizados en unidades convencionales, adecuado para evaluar y comparar la efectividad y la calidad de la asistencia sanitaria en ...
    • Modulating Glypican4 suppresses tumorigenicity of embryonic stem cells while preserving self-renewal and pluripotency 

      Fico, Annalisa; Chevigny, Antoine De; Egea Navarro, Joaquim; Bösl, Michael R.; Cremer, Harold; Maina, Flavio; Dono, Rosanna (Wiley, 2012)
      Self-renewal and differentiation of stem cell depend on a dynamic interplay of cell-extrinsic and -intrinsic regulators. However, how stem cells perceive the right amount of signal and at the right time to undergo a ...
    • Modulation of plasma membrane lipid profile and microdomains by H2O2 in Saccharomyces cerevisiae 

      Pedroso, Nuno; Matias, Ana C.; Cyrne, Luísa; Antunes, Fernando; Borges, Carlos; Malhó, Rui; de Almeida, Rodrigo F.M.; Herrero Perpiñán, Enrique; Marinho, H. Susana (Elsevier, 2009)
      In Saccharomyces cerevisiae, the rate of hydrogen peroxide (H2O2) diffusion through the plasma membrane decreases during adaptation to H2O2 by a still unknown mechanism. Here, adaptation to H2O2 was observed to modulate ...
    • Molecular Basis of Tumor Heterogeneity in Endometrial Carcinosarcoma 

      Leskelä, Susanna; Pérez-Mies, Belén; Rosa-Rosa, Juan Manuel; Cristobal, Eva; Biscuola, Michele; Palacios-Berraquero, María L.; Ong, SuFey; Matias-Guiu, Xavier; Palacios, José (MDPI, 2019)
      Endometrial carcinosarcoma (ECS) represents one of the most extreme examples of tumor heterogeneity among human cancers. ECS is a clinically aggressive, high-grade, metaplastic carcinoma. At the morphological level, ...