Now showing items 246-265 of 560

    • GESAP trial rationale and methodology: management of patients with suspected obstructive sleep apnea in primary care units compared to sleep units 

      Tarraubella Balanya, Núria; Batlle Garcia, Jordi de; Nadal Braque, Núria; Castro-Grattoni, Anabel L.; Gómez Falguera, Silvia; Sánchez de la Torre, Manuel; Barbé Illa, Ferran (Nature Publishing Group, 2016-12)
      BACKGROUND Obstructive sleep apnea syndrome (OSA) is a chronic sleep disorder characterized by repeated episodes of upper airway collapse during sleep. This leads to arterial hypoxemia and sleep disruption and causes daytime ...
    • Glial cell line-derived neurotrophic factor increases intracellular calcium concentration. Role of calcium/calmodulin in the activation of the phosphatidylinositol 3-kinase pathway 

      Pérez García, María José; Ceña, Valentín; Pablo Llavall, Yolanda de; Llovera i Tomàs, Marta; Comella i Carnicé, Joan Xavier; Soler i Tatché, Rosa Ma. (American Society for Biochemistry and Molecular Biology; Elsevier, 2004)
      Moderate increases of intracellular Ca2+ concentration ([Ca2+]i), induced by either the activation of tropomyosin receptor kinase (Trk) receptors for neurotrophins or by neuronal activity, regulate different intracellular ...
    • Glutaredoxins Grx3 and Grx4 regulate nuclear localisation of Aft1 and the oxidative stress response in Saccharomyces cerevisiae 

      Pujol Carrión, Núria; Bellí i Martínez, Gemma; Herrero Perpiñán, Enrique; Nogues, Antoni; Torre Ruiz, M. A. de la (Company of Biologists, 2006)
      Grx3 and Grx4, two monothiol glutaredoxins of Saccharomyces cerevisiae, regulate Aft1 nuclear localisation. We provide evidence of a negative regulation of Aft1 activity by Grx3 and Grx4. The Grx domain of both proteins ...
    • Glutaredoxins Grx4 and Grx3 of Saccharomyces cerevisiae Play a Role in Actin Dynamics through Their Trx Domains, Which Contributes to Oxidative Stress Resistance 

      Pujol Carrión, Núria; Torre Ruiz, M. A. de la (American Society for Microbiology, 2010)
      Grx3 and Grx4 are two monothiol glutaredoxins of Saccharomyces cerevisiae that have previously been characterized as regulators of Aft1 localization and therefore of iron homeostasis. In this study, we present data showing ...
    • Glutaredoxins in fungi 

      Herrero Perpiñán, Enrique; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi; Bellí i Martínez, Gemma (Springer, 2006)
      Glutaredoxins (GRXs) can be subdivided into two subfamilies: dithiol GRXs with the CPY/FC active site motif, and monothiol GRXs with the CGFS motif. Both subfamilies share a thioredoxin-fold structure. Monothiol GRXs exist ...
    • Grx5 glutaredoxin plays a central role in protection against protein oxidative damage in Saccharomyces cerevisiae 

      Rodríguez Manzanaque, Maria Teresa; Ros Salvador, Joaquim; Cabiscol Català, Elisa; Sorribas Tello, Albert; Herrero Perpiñán, Enrique (American Society for Microbiology, 1999)
      Glutaredoxins are members of a superfamily of thiol disulfide oxidoreductases involved in maintaining the redox state of target proteins. In Saccharomyces cerevisiae, two glutaredoxins (Grx1 and Grx2) containing a cysteine ...
    • Grx5 is a mitochondrial glutaredoxin required for the activity of iron/sulfur enzymes 

      Rodríguez-Manzaneque Martínez, María Teresa; Tamarit Sumalla, Jordi; Bellí i Martínez, Gemma; Ros Salvador, Joaquim; Herrero Perpiñán, Enrique (American Society for Cell Biology, 2002)
      Yeast cells contain a family of three monothiol glutaredoxins: Grx3, 4, and 5. Absence of Grx5 leads to constitutive oxidative damage, exacerbating that caused by external oxidants. Phenotypic defects associated with the ...
    • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 

      Klionsky, Daniel J.; Cantí Nicolás, Carles; Garcera, Ana; Herreros Danés, Judit; Soler i Tatché, Rosa Ma.; others (Taylor & Francis, 2021-02-08)
      In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant ...
    • HBPF: a Home Blood Pressure Framework with SLA guarantees to follow up hypertensive patients 

      Cuadrado, Josep; Vilaplana Mayoral, Jordi; Mateo Fornés, Jordi; Solsona Tehàs, Francesc; Solsona, Sara; Rius Torrentó, Josep Maria; Alves, Rui; Camafort, Miguel; Torres, Gerard; Betriu i Bars, M. Àngels; Gutiérrez Vilaplana, Josep M.; Fernández i Giráldez, Elvira (PeerJ, 2016)
      Hypertension or high blood pressure is a condition on the rise. Not only does it affect the elderly but is also increasingly spreading to younger sectors of the population. Treating it involves exhaustive monitoring of ...
    • Heat shock response in yeast involves changes in both transcription rates and mRNA stabilities 

      Castells i Roca, Laia; García-Martínez, José; Moreno, Joaquín; Herrero Perpiñán, Enrique; Bellí i Martínez, Gemma; Pérez-Ortín, José E. (Public Library of Science (PLoS), 2011)
      We have analyzed the heat stress response in the yeast Saccharomyces cerevisiae by determining mRNA levels and transcription rates for the whole transcriptome after a shift from 25uC to 37uC. Using an established mathematical ...
    • Hepatocyte vitamin D receptor regulates lipid metabolism and mediates experimental diet-induced steatosis 

      Bozić Stanojević, Milica; Guzmán, Carla; Benet, Marta; Sánchez-Campos, Sonia; García-Monzón, Carmelo; Garí Marsol, Eloi; Gatius Calderó, Sònia; Valdivielso Revilla, José Manuel; Jover, Ramiro (Elsevier, 2016)
      Background & Aims The pathogenesis and progression of non-alcoholic fatty liver disease (NAFLD) is still incompletely understood. Several nuclear receptors play a role in liver lipid metabolism and can promote ...
    • HGF regulates the development of cortical pyramidal dendrites 

      Gutierrez, Humberto; Dolcet Roca, Xavier; Tolcos, Mary; Davies, Alun M. (Company of Biologists Ltd., 2004-08)
      Although hepatocyte growth factor (HGF) and its receptor tyrosine kinase MET are widely expressed in the developing and mature central nervous system, little is known about the role of MET signaling in the brain. We have ...
    • HIF-1α- Targeting Acriflavine Provides Long Term Survival and Radiological Tumor Response in Brain Cancer Therapy 

      Mangraviti, Antonella; Raghavan, Tula; Volpin, Francesco; Skuli, Nicolas; Gullotti, David; Zhou, Jinyuan; Asnaghi, Laura; Sankey, Eric; Liu, Ann; Wang, Yuan; Lee, Dong-Hoon; Gorelick, Noah; Serra, Riccardo; Peters, Michael; Schriefer, Destiny; Delaspre, Fabien; Rodriguez, Fausto J.; Eberhart, Charles G.; Brem, Henry; Olivi, Alessandro; Tyler, Betty (Nature Publishing Group, 2017-12-01)
      Tumor progression, limited efficacy of current standard treatments, and the rise in patient mortality are associated with gene expression caused by the synergistic action of intratumoral hypoxia and HIF-1α activation. For ...
    • High levels of hemoglobin promote carotid adventitial vasa vasorum neoangiogenesis in chronic kidney disease 

      Arcidiacono, Maria V.; Martínez Alonso, Montserrat; Belart, Montserrat; Vilar, Ana; Martín, Marisa; Craver Hospital, Lourdes; Betriu i Bars, M. Àngels; Mauricio Puente, Dídac; Valdivielso Revilla, José Manuel; Fernández i Giráldez, Elvira; Borràs, Mercè (Hindawi, 2017-01-04)
      Chronic kidney disease (CKD) patients, characterized by traditional and nontraditional risk factors, are prone to develop atheromatosis and thus cardiovascular events and mortality. The angiogenesis of the adventitial vasa ...
    • High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene 

      Torres-Arzayus, Maria I.; Font de Mora, Jaime; Yuan, Jing; Vazquez, Francisca; Bronson, Roderick; Rué i Monné, Montserrat; Sellers, William R.; Brown, Myles (Elsevier, 2004)
      The gene encoding AIB1, an estrogen receptor coactivator, is amplified in a subset of human breast cancers. Here we show that overexpression of AIB1 in transgenic mice (AIB1-tg) leads to mammary hypertrophy, hyperplasia, ...
    • High-grade Endometrial Carcinomas: Morphologic and Immunohistochemical Features, Diagnostic Challenges and Recommendations 

      Murali, Rajmohan; Davidson, Ben; Fadare, Oluwole; Carlson, Joseph A.; Crum, Christopher; Gilks, C. Blake; Irving, Julie A.; Malpica, Anais; Matias-Guiu, Xavier; McCluggage, W. Glenn; Mittal, Khush; Oliva, Esther; Parkash, Vinita; Rutgers, Joanne; Staats, Paul; Stewart, Colin; Tornos, Carmen; Soslow, Robert A. (Lippincott, Williams & Wilkins, 2019)
      This review of challenging diagnostic issues concerning high-grade endometrial carcinomasisderivedfromtheauthors’ reviewoftheliteraturefollowedbydiscussionsatthe Endometrial Cancer Workshop sponsored by the International ...
    • Hippocampal neurons require a large pool of glutathione to sustain dendrite integrity and cognitive function 

      Fernandez-Fernandez, Seila; Bobo-Jimenez, Veronica; Requejo-Aguilar, Raquel; Gonzalez-Fernandez, Silvia; Resch, Monica; Carabias-Carrascoa, Monica; Ros Salvador, Joaquim; Almeida, Angeles; Bolaños, Juan P. (Elsevier, 2018)
      Loss of brain glutathione has been associated with cognitive decline and neuronal death during aging and neurodegenerative diseases. However, whether decreased glutathione precedes or follows neuronal dysfunction has not ...
    • Histone deacetylase inhibitors promote glioma cell death by G2 checkpoint abrogation leading to mitotic catastrophe 

      Cornago Protomártir, Marta; Garcia-Alberich, C.; Blasco Angulo, Natividad; Vall-llaura Espinosa, Núria; Nàger Grifo, Mireia; Herreros Danés, Judit; Comella i Carnicé, Joan Xavier; Sanchis, Daniel; Llovera i Tomàs, Marta (Nature Publishing Group, 2014-10-02)
      Glioblastoma multiforme is resistant to conventional anti-tumoral treatments due to its infiltrative nature and capability of relapse; therefore, research efforts focus on characterizing gliomagenesis and identifying ...
    • Human Menstrual Blood-Derived Mesenchymal Stem Cells as Potential Cell Carriers for Oncolytic Adenovirus 

      Moreno, R.; Rojas, L.A.; Vilardell, Felip; Cervera Soriano, Vanessa; García-Castro, J.; Fajardo, C. A.; Alemany, R. (Hindawi, 2017)
      Antitumor efficacy of systemically administered oncolytic adenoviruses (OAdv) is limited due to diverse factors such as liver sequestration, neutralizing interactions in blood, elimination by the immune system, and physical ...
    • Hypoxia-independent gene expression signature associated with radiosensitisation of prostate cancer cell lines by histone deacetylase inhibition 

      Jonsson, Marte; Ragnum, Harald Bull; Julin, Cathinka Halle; Yeramian Hakim, Andree; Clancy, Trevor; Frikstad, Kari-Anne Myrum; Seierstad, Therese; Stokke, Trond; Matias-Guiu, Xavier; Ree, Anne Hansen; Flatmark, Kjersti; Lyng, Heidi (Nature Publishing Group, 2016-10-11)
      Background: Histone deacetylase inhibitors (HDACis) like vorinostat are promising radiosensitisers in prostate cancer, but their effect under hypoxia is not known. We investigated gene expression associated with ...