Now showing items 162-181 of 505

    • EndoG links Bnip3-induced mitochondrial damage and caspase-independent DNA fragmentation in ischemic cardiomyocytes 

      Zhang, Jisheng; Ye, Junmei; Altafaj, Albert; Cardona Colom, Maria; Bahi i Pla, Núria; Llovera i Tomàs, Marta; Cañas, Xavier; Cook, Stuart A.; Comella i Carnicé, Joan Xavier; Sanchis, Daniel (Public Library of Science (PLoS), 2011)
      Mitochondrial dysfunction, caspase activation and caspase-dependent DNA fragmentation are involved in cell damage in many tissues. However, differentiated cardiomyocytes repress the expression of the canonical apoptotic ...
    • Endometrial Carcinoma Diagnosis: Use of FIGO Grading and Genomic Subcategories in Clinical Practice: Recommendations of the International Society of Gynecological Pathologists 

      Soslow, Robert A.; Tornos, Carmen; Park, Kay J.; Malpica, Anais; Matias-Guiu, Xavier; Oliva, Esther; Parkash, Vinita; Carlson, Joseph A.; McCluggage, W. Glenn; Gilks, C. Blake (Lippincott, Williams & Wilkins, 2019)
      In this review, we sought to address 2 important issues in the diagnosis of endometrial carcinoma: how to grade endometrial endometrioid carcinomas and how to incorporate the 4 genomic subcategories of endometrial carcinoma, ...
    • Endometrial Carcinoma, Grossing and Processing Issues: Recommendations of the International Society of Gynecologic Pathologists 

      Malpica, Anais; Euscher, Elizabeth; Hecht, Jonathan; Ali-Fehmi, Rouba; Quick, Charles; Singh, Naveena; Horn, Lars-Christian; Alvarado-Cabrero, Isabel; Matias-Guiu, Xavier; Hirschowitz, Lynn; Duggan, Máire; Ordi, Jaume; Parkash, Vinita; Mikami, Yoshiki; Quddus, M. Ruhul; Zaino, Richard; Staebler, Annette; Zaloudek, Charles; McCluggage, W. Glenn; Oliva, Esther (Lippincott, Williams & Wilkins, 2019)
      Endometrial cancer is the most common gynecologic neoplasm in developed countries; however, updated universal guidelines are currently not available to handle specimens obtained during the surgical treatment of patients ...
    • Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function 

      McDermott Roe, Chris; Ye, Junmei; Ahmed, Rizwan; Sun, Xi-Ming; Serafín, Anna; Ware, James; Bottolo, Leonardo; Muckett, Phil; Cañas, Xavier; Zhang, Jisheng; Rowe, Glenn C.; Buchan, Rachel; Lu, Han; Braithwaite, Adam; Mancini, Massimiliano; Hauton, David; Martí, Ramon; García Arumí, Elena; Hubner, Norbert; Jacob, Howard; Serikawa, Tadao; Zidek, Vaclav; Papousek, Frantisek; Kolar, Frantisek; Cardona Colom, Maria; Ruiz Meana, Marisol; García Dorado, David; Comella i Carnicé, Joan Xavier; Felkin, Leanne E.; Barton, Paul J. R.; Zoltan Arany; Pravenec, Michal; Petretto, Enrico; Sanchis, Daniel; Cook, Stuart A. (Macmillan Publishers Limited, 2011)
      Left ventricular mass (LVM) is a highly heritable trait1 and an independent risk factor for all-cause mortality2. So far, genome-wide association studies have not identified the genetic factors that underlie LVM variation3, ...
    • Engineered Trx2p industrial yeast strain protects glycolysis and fermentation proteins from oxidative carbonylation during biomass propagation 

      Gómez-Pastor, Rocío; Pérez-Torrado, Roberto; Cabiscol Català, Elisa; Ros Salvador, Joaquim; Matallana, Emilia (BioMed Central, 2012)
      Background: In the yeast biomass production process, protein carbonylation has severe adverse effects since it diminishes biomass yield and profitability of industrial production plants. However, this significant detriment ...
    • Enhanced synaptic plasticity and spatial memory in female but not male FLRT2-haplodeficient mice 

      Cicvaric, Ana; Yang, Jiaye; Bulat, Tanja; Zambon, Alice; Dominguez-Rodriguez, Manuel; Kühn, Rebekka; Sadowicz, Michael G.; Siwert, Anjana; Egea Navarro, Joaquim; Pollak, Daniela D.; Moeslinger, Thomas; Monje, Francisco J. (Nature Publishing Group, 2018)
      The Fibronectin Leucine-Rich Transmembrane protein 2 (FLRT2) has been implicated in several hormone -and sex-dependent physiological and pathological processes (including chondrogenesis, menarche and breast cancer); is ...
    • EphA4-Dependent Axon Guidance Is Mediated by the RacGAP a2-Chimaerin 

      Wegmeyer, Heike; Egea Navarro, Joaquim; Rabe, Nadine; Gezelius, Henrik; Filosa, Alessandro; Enjin, Anders; Varoqueaux, Frederique; Deininger, Katrin; Schnütgen, Frank; Brose, Nils; Klein, Rüdiger; Kullander, Klas; Betz, Andrea (Elsevier, 2007)
      Neuronal network formation in the developing nervous system is dependent on the accurate navigation of nerve cell axons and dendrites, which is controlled by attractive and repulsive guidance cues. Ephrins and their ...
    • Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis 

      Moran, Sebastian; Martínez Cardús, Anna; Sayols, Sergi; Musulén, Eva; Balañá, Carme; Estival Gonzalez, Anna; Moutinho, Cátia; Heyn, Holger; Diaz Lagares, Angel; Castro de Moura, Manuel; Stella, Giulia M.; Comoglio, Paolo M.; Ruiz Miró, Maria; Pazo Cid, Roberto; Antón, Antonio; Lopez Lopez, Rafael; Soler, Gemma; Longo, Federico; Guerra, Isabel; Fernandez, Sara; Assenov, Yassen; Plass, Christoph; Morales, Rafael; Carles, Joan; Bowtell, David; Mileshkin, Linda; Sia, Daniela; Tothill, Richard; Tabernero, Josep; Llovet, Josep M.; Esteller, Manel; Matias-Guiu, Xavier (Elsevier, 2016)
      Cancer of unknown primary ranks in the top ten cancer presentations and has an extremely poor prognosis. Identification of the primary tumour and development of a tailored site-specific therapy could improve the survival ...
    • ER alpha-mediated repression of pro-inflammatory cytokine expression by glucocorticoids reveals a crucial role for TNF alpha and IL1 alpha in lumen formation and maintenance 

      Eritja Sánchez, Núria; Mirantes Barbeito, Cristina; Llobet Navàs, David; Masip Vilà, Gemma; Matias-Guiu, Xavier; Dolcet Roca, Xavier (Company of Biologists Ltd., 2013)
      Most glandular tissues comprise polarized epithelial cells organized around a single central lumen. Although there is active research investigating the molecular networks involved in the regulation of lumenogenesis, little ...
    • Erectile dysfunction in obstructive sleep apnea patients: A randomized trial on the effects of Continuous Positive Airway Pressure (CPAP) 

      Pascual, Mercè; Batlle Garcia, Jordi de; Barbé Illa, Ferran; Castro-Grattoni, Anabel L.; Auguet, Josep M.; Pascual, Lydia; Vilà, Manel; Cortijo, Anunciación; Sánchez de la Torre, Manuel (Public Library of Science, 2018)
      Objectives Obstructive sleep apnea (OSA) is among the least studied risk factors for erectile dysfunction (ED). We aimed to determine ED prevalence in newly-diagnosed OSA patients, describe their main characteristics ...
    • Erk1/2 activation in stromal fibroblasts from sporadic basal cell carcinomas 

      Aguayo Ortiz, Rafael; Rafel i Borrell, Marta; Santacana Espasa, Maria; Pérez Fusté, Noel; Garí Marsol, Eloi (American Society for Dermatologic Surgery, 2015)
      BACKGROUND Constitutive activation of the Erk pathway can lead to oncogenic transformation. However, the Erk pathway is not activated in human basal cell carcinomas (BCCs); although in animal models, this seems to be ...
    • Estimation of age- and stage-specific Catalan breast cancer survival functions using US and Catalan survival data 

      Vilaprinyo Terré, Ester; Rué i Monné, Montserrat; Marcos-Gragera, Rafael; Martínez Alonso, Montserrat (BioMed Central, 2009)
      Background: During the last part of the 1990s the chance of surviving breast cancer increased. Changes in survival functions reflect a mixture of effects. Both, the introduction of adjuvant treatments and early screening ...
    • Estudio de intervención aleatorizado para evaluar la prevalencia de enfermedad ateromatosa y renal ocultas y su impacto en la morbimortalidad: Proyecto ILERVA 

      Betriu i Bars, M. Àngels; Farràs-Sallés, Cristina; Abajo, María; Martínez Alonso, Montserrat; Arroyo, David; Barbé Illa, Ferran; Buti, Miquel; Lecube Torelló, Albert; Portero Otín, Manuel; Purroy Garcia, Francisco; Torres, Gerard; Valdivielso Revilla, José Manuel; Fernández i Giráldez, Elvira (Sociedad Española de Nefrología, 2016)
      Antecedentes y objetivos: La enfermedad renal crónica (ERC) y la ateromatosis son 2 enfermedades interrelacionadas que aumentan el riesgo de morbimortalidad cardiovascular. Los objetivos del proyecto ILERVAS son: 1) conocer ...
    • Estudio descriptivo sobre el uso de la anticoncepción de emergencia en Cataluña. Comparación entre una zona rural y una urbana 

      Ros, Clara; Miret, Marta; Rué i Monné, Montserrat (Elsevier, 2009)
      Objective: In the last few years, the number of unplanned pregnancies has increased, especially in young women. Among other measures, emergency contraception (EC) was introduced by the Health Department to reduce unwanted ...
    • Estudio observacional del gasto farmacéutico en población inmigrante y autóctona de la región sanitaria de Lleida (Cataluña) 

      Rué i Monné, Montserrat; Bosch Gaya, Anna; Serna Arnaiz, Catalina; Soler González, Jorge; Galván, Leonardo; Cruz Esteve, María Inés (Elsevier, 2010)
      Objetivos Analizar si hay diferencias en el gasto farmacéutico entre inmigrantes y autóctonos en la población general y si el ámbito de residencia (urbano/rural) está asociado al gasto en farmacia. Diseño Estudio ...
    • ETV6 mutations in early immature human T cell leukemias 

      Vlierberghe, Pieter Van; Ambesi-Impiombato, Alberto; Pérez-García, Arianne; Haydu, J. Erika; Rigo, Isaura; Hadler, Michael; Tosello, Valeria; Della Gatta, Giusy; Paietta, Elisabeth; Racevskis, Janis; Wiernik, Peter H.; Luger, Selina M.; Rowe, Jacob M.; Rué i Monné, Montserrat; Ferrando, Adolfo A. (The Rockefeller University Press, 2011)
      Early immature T cell acute lymphoblastic leukemias (T-ALLs) account for 5–10% of pediatric T-ALLs and are associated with poor prognosis. However, the genetic defects that drive the biology of these tumors remain largely ...
    • EV-associated miRNAs from peritoneal lavage as potential diagnostic biomarkers in colorectal cancer 

      Roman-Canal, Berta; Tarragona Foradada, Jordi; Moiola, Cristian P.; Gatius Calderó, Sònia; Bonnin, Sarah; Ruiz Miró, Maria; Sierra, José Enrique; Rufas, Maria; González, Esperanza; Porcel Pérez, José Manuel; Gil-Moreno, Antonio; Falcon-Perez, Juan M.; Ponomarenko, Julia; Matias-Guiu, Xavier; Colás, Eva (BioMed Central, 2019)
      Background: Colorectal cancer (CRC) is the third leading cause of cancer-related mortality worldwide. Current systematic methods for diagnosing have inherent limitations so development of a minimally-invasive diagnosis, ...
    • EV-associated miRNAs from pleural lavage as potential diagnostic biomarkers in lung cancer 

      Roman-Canal, Berta; Moiola, Cristian P.; Gatius Calderó, Sònia; Bonnin, Sarah; Ruiz Miró, Maria; González, Esperanza; Ojanguren, Amaia; Recuero, José Luis; Gil-Moreno, Antonio; Falcón-Pérez, Juan M.; Ponomarenko, Julia; Porcel Pérez, José Manuel; Matias-Guiu, Xavier; Colás, Eva (Nature Research, 2019)
      Lung cancer is the leading cause of cancer-related deaths among men and women in the world, accounting for the 25% of cancer mortality. Early diagnosis is an unmet clinical issue. In this work, we focused to develop a ...
    • Evaluating multi-locus phylogenies for species boundaries determination in the genus Diaporthe 

      Santos, Liliana; Alves, Artur; Alves, Rui (Peerj, 2017-03-28)
      Background. Species identification is essential for controlling disease, understanding epidemiology, and to guide the implementation of phytosanitary measures against fungi from the genus Diaporthe. Accurate Diaporthe ...
    • Evaluation of health benefits and harms of the breast cancer screening programme in the Basque Country using discrete event simulation 

      Rué i Monné, Montserrat; Arrospide, Arantzazu; Ravesteyn, Nicolien T. van; Comas, Mercè; Larrañaga, Nerea; Sarriugarte, Garbiñe; Mar, Javier (BioMed Central, 2015)
      Background: Since the breast cancer screening programme in the Basque Country (BCSPBC) was started in 1996, more than 400,000 women aged 50 to 69 years have been invited to participate. Based on epidemiological observations ...