Browsing Articles publicats (Ciències Mèdiques Bàsiques) by Title
Now showing items 146-165 of 548
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Differential Immunoexpression of BRAF/V600E, Senescence Markers, PTEN, and T-type Calcium Channels in Acquired Naevi According to their Histopathological and Dermoscopic Classification
(Society for Publication of Acta Dermato-Venereologica, 2021)BRAF/V600E mutation and other cell growth/growth-control mechanisms are involved in naevogenesis and melanomagenesis. Immunoexpression of BRAF/V600E and other molecules (p16, phosphatase and tensin homologue (PTEN), Ki67, ... -
Differential Inactivation of Alcohol Dehydrogenase Isoenzymes in Zymomonas mobilis by Oxygen
(American Society for Microbiology, 1997)Zymomonas mobilis is endowed with two isoenzymes of fermentative alcohol dehydrogenase, a zinc-containing enzyme (ADH I) and an iron-containing enzyme (ADH II). The activity of ADH I remains fully conserved, while ADH ... -
Directed pancreatic acinar differentiation of mouse embryonic stem cells via embryonic signalling molecules and exocrine transcription factors
(Public Library of Science, 2013-01-17)Pluripotent embryonic stem cells (ESC) are a promising cellular system for generating an unlimited source of tissue for the treatment of chronic diseases and valuable in vitro differentiation models for drug testing. Our ... -
Disease-specific health-related quality of life questionnaires for heart failure: a systematic review with meta-analyses
(Springer Verlag, 2009)Background Heart failure (HF) is an increasingly common condition affecting patients’ health-related quality of life (HRQL). However, there is little literature comparing HF-specific instruments. Our aim was to evaluate and ... -
Dissecting the Transcriptional Regulatory Properties of Human Chromosome 16 Highly Conserved Non-Coding Regions
(Public Library of Science, 2011)Non-coding DNA conservation across species has been often used as a predictor for transcriptional enhancer activity. However, only a few systematic analyses of the function of these highly conserved non-coding regions ... -
Dissemination of periodic mammography and patterns of use, by birth cohort, in Catalonia (Spain)
(BioMed Central, 2008)Background: In Catalonia (Spain) breast cancer mortality has declined since the beginning of the 1990s. The dissemination of early detection by mammography and the introduction of adjuvant treatments are among the possible ... -
Distribution of functional polymorphic variants of inflammation-related genes RANTES and CCR5 in long-lived individuals
(Elsevier, 2012)Although persistent inflammation has been related to unsuccessful aging, a pro-inflammatory status is the common phenotype in older people. To assess for a genetic component in the inflammatory status of the oldest we ... -
DNA activates the Nse2/Mms21 SUMO E3 ligase in the Smc5/6 complex
(EMBO Press, 2018-06-15)Modification of chromosomal proteins by conjugation to SUMO is a key step to cope with DNA damage and to maintain the integrity of the genome. The recruitment of SUMO E3 ligases to chromatin may represent one layer of ... -
DnaK dependence of mutant ethanol oxidoreductases evolved for aerobic function and protective role of the chaperone against protein oxidative damage in Escherichia coli
(National Academy of Sciences, 2002)The adhE gene of Escherichia coli encodes a multifunctional ethanol oxidoreductase (AdhE) that catalyzes successive reductions of acetyl-CoA to acetaldehyde and then to ethanol reversibly at the expense of NADH. Mutant ... -
Does an oral analgesic protocol improve pain control for patients with cancer? An intergroup study coordinated by the Eastern Cooperative Oncology Group
(Oxford University Press, 2005)Background: Cancer pain is highly prevalent and commonly undertreated. This study was designed to determine whether dissemination of a clinical protocol for pain management would improve outcomes in community oncology ... -
Down-regulation of fatty acid synthase increases the resistance of Saccharomyces cerevisiae cells to H2O2
(Elsevier, 2007)Changes in plasma membrane permeability caused by H2O2 were recently found to be involved in the adaptation to H2O2, but the mechanism responsible for this change remains largely unknown. Here this mechanism was addressed ... -
Duration and compliance with antidepressant treatment in immigrant and native-born populations in Spain: a four year follow-up descriptive study
(BioMed Central, 2012)Background: Non-compliance with antidepressant treatment continues to be a complex problem in mental health care. In immigrant populations non-compliance is one of several barriers to adequate management of mental illness; ... -
EasyModel: user-friendly tool for building and analysis of simple mathematical models in systems biology
(Oxford University Press, 2019-08-26)EasyModel is a new user-friendly web application that contains ready-for-simulation versions of the BioModels Database, and allows for the intuitive creation of new models. Its main target audience is the experimental ... -
Economic evaluation of the breast cancer screening programme in the Basque Country: retrospective cost-effectiveness and budget impact analysis
(BMC Cancer, 2016)Background: Breast cancer screening in the Basque Country has shown 20 % reduction of the number of BC deaths and an acceptable overdiagnosis level (4 % of screen detected BC). The aim of this study was to evaluate the ... -
Economic evaluations of screening strategies for the early detection of colorectal cancer in the average-risk population: a systematic literature review
(Public Library of Science, 2019-12-31)Background Colorectal cancer (CRC) screening has proven effective in reducing CRC mortality. This study aimed to systematically review, and evaluate the reporting quality, of the economic evidence regarding CRC screening ... -
Efecto del diseño muestral en el análisis de encuestas de diseño complejo. Aplicación a la encuesta de salud de Catalunya
(Elsevier España, 2000)Objetivo: Ilustrar cómo se puede incorporar fácilmente el diseño muestral en el análisis estadístico de encuestas con diseños muestrales complejos, para obtener estimaciones correctas. Métodos: Se ha utilizado un programa ... -
Efecto diferencial de los análogos de la vitamina D en la proliferación de células de músculo liso vascular
(Sociedad Espanola de Nefrologia, 2003)Existen datos experimentales contradictorios respecto al comportamiento de las células de músculo liso vascular (CMLV) expuestas al calcitriol. Determinar el efecto del calcitriol y de sus análogos a nivel vascular tiene ... -
Effect of 8.5% and 25% caloric restriction on mitochondrial free radical production and oxidative stress in rat liver
(Springer Verlag, 2007)Previous studies have consistently shown that 40% caloric restriction (CR) decreases the rate of mitochondrial ROS production and steady-state levels of markers of oxidative damage to macromolecules including mitochondrial ... -
Effect of Continuous Positive Airway Pressure on the Incidence of Hypertension and Cardiovascular Eventsin Nonsleepy Patients With Obstructive Sleep Apnea
(American Medical Association, 2013)Context Continuous positive airway pressure (CPAP) is the first-line treatment for patients with symptomatic obstructive sleep apnea (OSA). However, its indication for all patients with sleep-disordered breathing, ... -
Effect of information about the benefits and harms of mammography on women's decision making: The InforMa randomised controlled trial
(Public Library of Science, 2019-03-26)BACKGROUND: In Spain, women invited to breast screening are not usually informed about potential harms of screening. The objective of the InforMa study is to assess the effect of receiving information about the benefits ...