Now showing items 499-502 of 502

    • Yeast as a model system to study metabolic impact of selenium compounds 

      Herrero Perpiñán, Enrique; Wellinger, Ralf Erik (Shared Science Publishers, 2015)
      Inorganic Se forms such as selenate or selenite (the two more abundant forms in nature) can be toxic in Saccharomyces cerevisiae cells, which constitute an adequate model to study such toxicity at the molecular level ...
    • Yeast frataxin mutants display decreased superoxide dismutase activity crucial to promote protein oxidative damage 

      Irazusta, Verónica Patricia; Obis Monné, Èlia; Moreno Cermeño, Armando J.; Cabiscol Català, Elisa; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (Elsevier, 2010)
      Iron overload is involved in several pathological conditions, including Friedreich ataxia, a disease caused by decreased expression of the mitochondrial protein frataxin. In a previous study, we identified 14 proteins ...
    • Zim17/Tim15 links mitochondrial iron–sulfur cluster biosynthesis to nuclear genome stability 

      Díaz de la Loza, María del Carmen; Gallardo, Mercedes; García-Rubio, María Luisa; Izquierdo, Alicia; Herrero Perpiñán, Enrique; Aguilera, Andrés; Wellinger, Ralf Erik (Oxford University Press, 2011)
      Genomic instability is related to a wide-range of human diseases. Here, we show that mitochondrial iron–sulfur cluster biosynthesis is important for the maintenance of nuclear genome stability in Saccharomyces cerevisiae. ...
    • β-catenin signalling in Glioblastoma multiforme and Glioma-initiating cells 

      Nàger Grifo, Mireia; Bhardwaj, Deepshikha; Cantí Nicolás, Carles; Medina Hernández, Loreta Mª; Nogués Bara, Pere; Herreros Danés, Judit (Hindawi Publishing Corporation, 2012)
      Glioblastoma multiforme (GBM) is a commonly occurring brain tumor with a poor prognosis. GBM can develop both “de novo” or evolve from a previous astrocytoma and is characterized by high proliferation and infiltration into ...