Browsing Articles publicats (Ciències Mèdiques Bàsiques) by Title
Now showing items 514-523 of 523
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What is microbiology gaining from genomics?
(Springer-Verlag Ibérica, 1999) -
When cholesterol is not cholesterol: a note on the enzymatic determination of its concentration in model systems containing vegetable extracts
(BioMed Central, 2010)Background: Experimental evidences demonstrate that vegetable derived extracts inhibit cholesterol absorption in the gastrointestinal tract. To further explore the mechanisms behind, we modeled duodenal contents with several ... -
Whi3 binds the mRNA of the G(1) cyclin CLN3 to modulate cell fate in budding yeast
(Cold Spring Harbor Laboratory Press, 2001)Eukaryotic cells commit in G1 to a new mitotic cycle or to diverse differentiation processes. Here we show that Whi3 is a negative regulator of Cln3, a G1 cyclin that promotes transcription of many genes to trigger the ... -
Whi3 regulates morphogenesis in budding yeast by enhancing Cdk functions in apical growth
(Landes Bioscience, 2009)The Whi3 protein is associated with the endoplasmic reticulum, interacts with Cdc28, the budding-yeast Cdk, binds the mRNA of cyclin CLN3 and prevents accumulation of the Cdc28-Cln3 in the nucleus until late G1. Besides ... -
Whi3, a developmental regulator of budding yeast, binds a large set of mRNAs functionally related to the endoplasmic reticulum
(American Society for Biochemistry and Molecular Biology, 2008)Whi3 is an RNA-binding protein associated with the endoplasmic reticulum (ER) that binds the CLN3 mRNA and plays a key role in the efficient retention of cyclin Cln3 at the ER. In the present work, we have identified new ... -
Wnt-3a and Wnt-3 differently stimulate proliferation and neurogenesis of spinal neural precursors and promote neurite outgrowth by canonical signaling
(Wiley, 2010)Wnt factors regulate neural stem cell development and neuronal connectivity. Here we investigated whether Wnt-3a and Wnt-3, expressed in the developing spinal cord, regulate proliferation and the neuronal differentiation ... -
Yeast as a model system to study metabolic impact of selenium compounds
(Shared Science Publishers, 2015)Inorganic Se forms such as selenate or selenite (the two more abundant forms in nature) can be toxic in Saccharomyces cerevisiae cells, which constitute an adequate model to study such toxicity at the molecular level ... -
Yeast frataxin mutants display decreased superoxide dismutase activity crucial to promote protein oxidative damage
(Elsevier, 2010)Iron overload is involved in several pathological conditions, including Friedreich ataxia, a disease caused by decreased expression of the mitochondrial protein frataxin. In a previous study, we identified 14 proteins ... -
Zim17/Tim15 links mitochondrial iron–sulfur cluster biosynthesis to nuclear genome stability
(Oxford University Press, 2011)Genomic instability is related to a wide-range of human diseases. Here, we show that mitochondrial iron–sulfur cluster biosynthesis is important for the maintenance of nuclear genome stability in Saccharomyces cerevisiae. ... -
β-catenin signalling in Glioblastoma multiforme and Glioma-initiating cells
(Hindawi Publishing Corporation, 2012)Glioblastoma multiforme (GBM) is a commonly occurring brain tumor with a poor prognosis. GBM can develop both “de novo” or evolve from a previous astrocytoma and is characterized by high proliferation and infiltration into ...