Now showing items 471-490 of 559

    • T-type Ca2+ Channels: T for Targetable 

      Crespí Sallán, Marta; Visa Pretel, Anna; Shaikh, Soni; Nàger Grifo, Mireia; Herreros Danés, Judit; Cantí Nicolás, Carles (Taylor & Francis, 2018-01-17)
      In the last decade TTCC have been unveiled as key regulators of cancer cells biology and thus have been proposed as chemotherapeutic targets. Indeed in vitro and in vivo studies indicate that TTCC pharmacological blockers ...
    • T-type calcium channels drive migration/invasion in BRAFV600E melanoma cells through Snail1 

      Maiques Carlos, Oscar; Barceló Gómez, Carla; Panosa, Anaïs; Pijuan Marquilles, Jordi; Orgaz, Jose L.; Rodríguez Hernández, Irene; Matas Nadal, Clara; Tell, Gemma; Vilella, Ramón; Fabra, Angels; Puig, Susana; Sanz Moreno, Victoria; Matias-Guiu, Xavier; Cantí Nicolás, Carles; Herreros Danés, Judit; Martí Laborda, Rosa Ma.; Macià Armengol, Anna (Wiley, 2018)
      Melanoma is a malignant tumor derived from melanocytes. Once disseminated, it is usually highly resistant to chemotherapy and is associated with poor prognosis. We have recently reported that T-type calcium channels (TTCCs) ...
    • T-type Cav3.1 channels mediate progression and chemotherapeutic resistance in glioblastoma 

      Visa Pretel, Anna; Crespí Sallán, Marta; Maiques Carlos, Oscar; Alza, Lía; Talavera, Elisabeth; López Ortega, Ricard; Santacana Espasa, Maria; Herreros Danés, Judit; Cantí Nicolás, Carles (American Association for Cancer Research, 2019)
      T-type Ca2+ channels (TTCC) have been identified as key regulators of cancer cell cycle and survival. In vivo studies in glioblastoma (GBM) murine xenografts have shown that drugs able to block TTCC in vitro (such as ...
    • T-type channels in cancer cells: Driving in reverse 

      Alza, Lía; Visa Pretel, Anna; Herreros Danés, Judit; Cantí Nicolás, Carles (Elsevier, 2022-06-06)
      In the strongly polarized membranes of excitable cells, activation of T-type Ca2+ channels (TTCCs) by weak depolarizing stimuli allows the influx of Ca2+ which further amplifies membrane depolarization, thus 'recruiting' ...
    • Tagging long-lived individuals through vitamin-D receptor (VDR) haplotypes 

      Laplana Lafaja, Marina; Sánchez de la Torre, Manuel; Aguiló, Alicia; Casado, Ignasi; Flores, Miquel; Sánchez-Pellicer, Ramon; Fibla Palazón, Joan (Springer, 2010)
      Longevity is a complex phenomenon involving multiple environmental and biological factors. Genetic studies of longevity have focussed on DNA repair, oxidative damage correction and immune-related genes. Vitamin-D works by ...
    • Targeted transcriptomic and metabolic profiling reveals temporal bottlenecks in the maize carotenoid pathway that may be addressed by multigene engineering 

      Farré Martinez, Gemma; Rivera Vélez, Sol Maiam; Alves, Rui; Vilaprinyo Terré, Ester; Sorribas Tello, Albert; Canela i Garayoa, Ramon; Naqvi, Shaista; Sandmann, Gerhard; Capell Capell, Teresa; Zhu, Changfu; Christou, Paul (Wiley, 2013)
      Carotenoids are a diverse group of tetraterpenoid pigments found in plants, fungi, bacteria and some animals. They play vital roles in plants and provide important health benefits to mammals, including humans. We ...
    • Targeting T-type channels in cancer: what is on and what is off? 

      Visa Pretel, Anna; Alza, Lía; Casas Benito, Adrian; Herreros Danés, Judit; Cantí Nicolás, Carles (Elsevier, 2022)
      Over the last 20 years several studies have demonstrated a pivotal role of T‐type calcium channels (TTCCs) in tumor progression. Cytotoxic effects of TTCC pharmacological blockers have been reported in vitro and in preclinical ...
    • Tau inhibits mitochondrial calcium efflux and makes neurons vulnerable to calciuminduced cell death 

      Britti, Elena; Ros Salvador, Joaquim; Esteras, Noemi; Abramov, Andey Y. (Elsevier, 2020-03)
      Aggregation or phosphorylation of the microtubule-associated protein tau is the pathological hallmark in a number of diseases termed tauopathies, which include the most common neurodegenerative disorder, Alzheimer’s disease; ...
    • TControl: A mobile app to follow up tobacco-quitting patients 

      Pifarré Montalà, Marc; Carrera Peruga, Adrián; Vilaplana Mayoral, Jordi; Cuadrado, Josep; Solsona, Sara; Abella i Pons, Francesc; Solsona Tehàs, Francesc; Alves, Rui (Elsevier, 2017-04)
      Background and Objective Tobacco smoking is a major risk factor for a wide range of respiratory and circulatory diseases in active and passive smokers. Well-designed campaigns are raising awareness to the problem and an ...
    • Tenosynovitis with rice body formation presenting as a cutaneous abscess 

      Moreno, Sara; Forcada Calvet, Pau; Soria, Xavier; Altemir, Victoria; Gatius Calderó, Sònia; Gil, Mabel; Matias-Guiu, Xavier; Casanova i Seuma, Josep M. (Josep Manel); Martí Laborda, Rosa Ma. (John Wiley & Sons, 2014)
      A 62-year-old woman with a past medical history of rheumatoid arthritis was referred to the Department of Dermatology because of an enlarging cutaneous lesion on the right thumb which resembled a soft tissue infection. ...
    • Tetralol derivative NNC-55-0396 induces glioblastoma cell death by activating IRE1α, JNK1 and calcium signaling 

      Visa Pretel, Anna; Alza, Lía; Cantí Nicolás, Carles; Herreros Danés, Judit (Elsevier, 2022-04-04)
      Mibefradil and NNC-55-0396, tetralol derivatives with a proven ability to block T-type calcium channels in excitable cells, reduce cancer cell viability in vitro, causing cell death. Furthermore, they reduce tumor growth ...
    • TGF-β-Induced transcription sustains amoeboid melanoma migration and dissemination 

      Cantelli, Gaia; Orgaz, Jose L.; Rodríguez Hernández, Irene; Karagiannis, Panagiotis; Maiques Carlos, Oscar; Matias-Guiu, Xavier; Nestle, Frank O.; Martí Laborda, Rosa Ma.; Karagiannis, Sophia N.; Sanz Moreno, Victoria (Elsevier, 2015)
      Cell migration underlies metastatic dissemination of cancer cells, and fast “amoeboid” migration in the invasive fronts of tumors is controlled by high levels of actomyosin contractility. How amoeboid migration is regulated ...
    • The Absence of Oligonucleosomal DNA Fragmentation during Apoptosis of IMR-5 Neuroblastoma Cells 

      Yuste Mateos, Víctor J. (Víctor José); Bayascas Ramírez, José Ramón; Llecha Cano, Núria; Sánchez-López, Isabel; Boix Torras, Jacint; Comella i Carnicé, Joan Xavier (American Society for Biochemistry and Molecular Biology, 2001)
      Caspase-activated DNase is responsible for the oligonucleosomal DNA degradation during apoptosis. DNA degradation is thought to be important for multicellular organisms to prevent oncogenic transformation or as a mechanism ...
    • The Activating Component of the Anaerobic Ribonucleotide Reductase from Escherichia coli 

      Tamarit Sumalla, Jordi; Gerez, Catherine; Meier, Christian; Mulliez, Etienne; Trautwein, Alfred; Fontecave, Marc (American Society for Biochemistry and Molecular Biology, 2000)
      Class III anaerobic ribonucleotide reductase small component, named protein b, contains a (4Fe-4S) center. Its function is to mediate electron transfer from reduced flavodoxin to S-adenosylmethionine, required for ...
    • The AMPK family member Snf1 protects Saccharomyces cerevisiae cells upon glutatione oxidation 

      Pérez Sampietro, María; Casas Herranz, Celia; Herrero Perpiñán, Enrique (Public Library of Science, 2013)
      The AMPK/Snf1 kinase has a central role in carbon metabolism homeostasis in Saccharomyces cerevisiae. In this study, we show that Snf1 activity, which requires phosphorylation of the Thr210 residue, is needed for protection ...
    • The Anaerobic Ribonucleotide Reductase from Escherichia coli 

      Tamarit Sumalla, Jordi; Mulliez, Etienne; Meier, Christian; Trautwein, Alfred; Fontecave, Marc (American Society for Biochemistry and Molecular Biology, 1999)
      For deoxyribonucleotide synthesis during anaerobic growth, Escherichia coli cells depend on an oxygen-sensitive class III ribonucleotide reductase. The enzyme system consists of two proteins: protein a, on which ribo ...
    • The Aurora-B-dependent NoCut checkpoint prevents damage of anaphase bridges after DNA replication stress 

      Amaral, Nuno; Vendrell, Alexandre; Maier, Michael; Kumar, Arun; Mendoza, Manuel; Funaya, Charlotta; Geli, María Isabel; Idrissi, Fatima-Zahra; Colomina i Gabarrella, Neus; Torres Rosell, Jordi (Nature, 2016)
      Anaphase chromatin bridges can lead to chromosome breakage if not properly resolved before completion of cytokinesis. The NoCut checkpoint, which depends on Aurora B at the spindle midzone, delays abscission in response ...
    • The bronchodilator test in chronic obstructive pulmonary disease: interpretation methods 

      Rodríguez-Carballeira, M.; Heredia, J. L.; Rué i Monné, Montserrat; Quintana, Salvador; Almagro, Pere (Elsevier, 2007)
      The objective of the study was to evaluate the best method for interpreting the bronchodilator test (BDT). Five formulas for expressing the BDT results were analyzed and compared: changes experienced by maximum ...
    • The Bronchodilator Test with Increasing Doses of Terbutaline in Chronic Obstructive Pulmonary Disease Patients 

      Rodríguez-Carballeira, M.; Heredia, J. L.; Rué i Monné, Montserrat; Quintana, Salvador; Gómez, S. (Elsevier, 2001)
      There is no uniform consensus on the dose of bronchodilator to be used in the bronchodilator test (BDT). The objective of the study was to determine the dose of inhaled terbutaline that can safely achieve a greater number ...
    • The cell cycle–regulated genes of schizosaccharomyces pombe 

      Oliva, Anna; Rosebrock, Adam; Ferrezuelo, Francisco; Pyne, Saumyadipta; Chen, Haiying; kiena, Steve; Futcher, Bruce; Leatherwood, Janet (Public Library of Science (PLoS), 2005)
      Many genes are regulated as an innate part of the eukaryotic cell cycle, and a complex transcriptional network helps enable the cyclic behavior of dividing cells. This transcriptional network has been studied in Saccharomyces ...