Now showing items 367-386 of 502

    • Quality of care indicators for a resuscitation unit: A descriptive study and proposal 

      Yuguero Torres, Oriol; Vena Martínez, Ana Belén; Forné Izquierdo, Carles; Lacasta García, José Daniel; Llobet, Cecilia; Abadías, María José (Lippincott, Williams & Wilkins, 2018)
      There are lack of indicators of quality of care in resuscitation units of emergency departments. With the aim of proposing a series of indicators to evaluate the quality of care delivered in hospital resuscitation areas, ...
    • Quality Reporting of Multivariable Regression Models in Observational Studies 

      Real, Jordi; Forné Izquierdo, Carles; Roso-Llorach, Albert; Martínez Sánchez, Jose M. (Lippincott, Williams & Wilkins, 2016)
      Controlling for confounders is a crucial step in analytical observational studies, and multivariable models are widely used as statistical adjustment techniques. However, the validation of the assumptions of the ...
    • Quantification of Unmethylated Alu (QUAlu): a tool to assess global hypomethylation in routine clinical samples 

      Buj, Raquel; Mallona, Izaskun; Díez Villanueva, Anna; Barrera, Víctor; Mauricio Puente, Dídac; Puig-Domingo, Manuel; Reverter, Jordi L.; Matias-Guiu, Xavier; Azuara, Daniel; Ramírez, Jose L.; Alonso, Sergio; Rosell, Rafael; Capellà, Gabriel; Perucho, Manuel; Robledo, Mercedes; Peinado, Miguel A.; Jordà, Mireia (Impact Journals, 2016)
      Hypomethylation of DNA is a hallmark of cancer and its analysis as tumor biomarker has been proposed, but its determination in clinical settings is hampered by lack of standardized methodologies. Here, we present QUAlu ...
    • Quantitative operating principles of yeast metabolism during adaptation to heat stress 

      Pereira, Tania; Vilaprinyo Terré, Ester; Bellí i Martínez, Gemma; Herrero Perpiñán, Enrique; Salvadó López, Baldiri; Sorribas Tello, Albert; Altés, Gisela; Alves, Rui (Elsevier, 2018)
      Microorganisms evolved adaptive responses to survive stressful challenges in ever-changing environments. Understanding the relationships between the physiological/metabolic adjustments allowing cellular stress adaptation ...
    • Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer 

      Wang, Yufei; McKay, James D.; Rafnar, Thorunn; Wang, Zhaoming; Timofeeva, Maria N.; Broderick, Peter; Zong, Xuchen; Laplana Lafaja, Marina; Wei, Yongyue; Han, Younghun; Lloyd, Amy; Delahaye-Sourdeix, Manon; Chubb, Daniel; Gaborieau, Valerie; Wheeler, William; Chatterjee, Nilanjan; Thorleifsson, Gudmar; Sulem, Patrick; Liu, Geoffrey; Kaaks, Rudolf; Henrion, Marc; Kinnersley, Ben; Vallée, Maxime; LeCalvez-Kelm, Florence; Stevens, Victoria L.; Gapstur, Susan M.; Chen, Wei V.; Zaridze, David; Szeszenia-Dabrowska, Neonilia; Lissowska, Jolanta; Rudnai, Peter; Fabianova, Eleonora; Mates, Dana; Bencko, Vladimir; Foretova, Lenka; Janout, Vladimir; Krokan, Hans E.; Gabrielsen, Maiken Elvestad; Skorpen, Frank; Vatten, Lars (Springer Nature, 2014)
      We conducted imputation to the 1000 Genomes Project of four genome-wide association studies of lung cancer in populations of European ancestry (11,348 cases and 15,861 controls) and genotyped an additional 10,246 cases and ...
    • Recruitment of Staufen2 Enhances Dendritic Localization of an Intron-Containing CaMKIIα mRNA 

      Ortiz, Raul; Georgieva, Maya V.; Gutiérrez, Sara; Pedraza González, Neus; Fernández-Moya, Sandra M.; Gallego, Carme (Elsevier, 2017)
      Regulation of mRNA localization is a conserved cellular process observed in many types of cells and organisms. Asymmetrical mRNA distribution plays a particularly important role in the nervous system, where local translation ...
    • Redox control and oxidative stress in yeast cells 

      Herrero Perpiñán, Enrique; Ros Salvador, Joaquim; Bellí i Martínez, Gemma; Cabiscol Català, Elisa (Elsevier, 2008)
      Protein structure and function can be altered by reactive oxygen species produced either by cell metabolism or by external oxidants. Although catalases, superoxide dismutases and peroxidases contribute to maintaining ...
    • Redox control of yeast Sir2 activity is involved in acetic acid resistance and longevity 

      Vall-llaura Espinosa, Núria; Mir, Noèlia; Garrido, Lourdes; Vived Maza, Celia; Cabiscol Català, Elisa (Elsevier, 2019-06)
      Yeast Sir2 is an NAD-dependent histone deacetylase related to oxidative stress and aging. In a previous study, we showed that Sir2 is regulated by S-glutathionylation of key cysteine residues located at the catalytic domain. ...
    • Reduction of oxidative cellular damage by overexpression of the thioredoxin TRX2 gene improves yield and quality of wine yeast dry active biomass 

      Gómez-Pastor, Rocío; Pérez-Torrado, Roberto; Cabiscol Català, Elisa; Ros Salvador, Joaquim; Matallana, Emilia (BioMed Central, 2010)
      Background: Wine Saccharomyces cerevisiae strains, adapted to anaerobic must fermentations, suffer oxidative stress when they are grown under aerobic conditions for biomass propagation in the industrial process of active ...
    • Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment 

      Georgouli, Mirella; Herraiz, Cecilia; Crosas-Molist, Eva; Fanshawe, Bruce; Maiques Carlos, Oscar; Perdrix, Anna; Pandya, Pahini; Rodríguez Hernández, Irene; Ilieva, Kristina M.; Cantelli, Gaia; Karagiannis, Panagiotis; Mele, Silvia; Lam, Hoyin; Josephs, Debra H.; Matias-Guiu, Xavier; Martí Laborda, Rosa Ma.; Nestle, Frank O.; Orgaz, Jose L.; Malanchi, Ilaria; Fruhwirth, Gilbert O.; Karagiannis, Sophia N.; Sanz Moreno, Victoria (Elsevier, 2019)
      ROCK-Myosin II drives fast rounded-amoeboid migration in cancer cells during metastatic dissemination. Analysis of human melanoma biopsies revealed that amoeboid melanoma cells with high Myosin II activity are predominant ...
    • Regulation of EphA4 Kinase Activity Is Required for a Subset of Axon Guidance Decisions Suggesting a Key Role for Receptor Clustering in Eph Function 

      Egea Navarro, Joaquim; Vig Nissen, Ulla; Dufour, Audrey; Sahin, Mustafa; Greer, Paul; Kullander, Klas; Mrsic-Flogel, Thomas D.; Greenberg, Michael E.; Kiehn, Ole; Vanderhaeghen, Pierre; Klein, Rüdiger (Elsevier, 2005)
      Signaling by receptor tyrosine kinases (RTKs) is mediated by their intrinsic kinase activity. Typically, kinase-activating mutations result in ligand-independent signaling and gain-of-function phenotypes. Like other RTKs, ...
    • Regulation of small GTPase activity by G1 cyclins 

      Pedraza González, Neus; Cemeli, Tània; Monserrat Monserrat, Maria Ventura; Garí Marsol, Eloi; Ferrezuelo, Francisco (Taylor & Francis, 2017-01-27)
      Together with a cyclin-dependent kinase (CDK) partner G1 cyclins control cell cycle entry by phosphorylating a number of nuclear targets and releasing a transcriptional program at the end of G1 phase. Yeast G1 cyclins also ...
    • Regulation of survival motor neuron protein by the nuclear factor-kappa B pathway in mouse spinal cord motoneurons 

      Arumugam, Saravanan; Tasheva, Stefka Mincheva; Periyakaruppiah, Ambika; Fuente Ruiz, Sandra de la; Soler i Tatché, Rosa Ma.; Garcera, Ana (Springer Verlag, 2017-08-14)
      Survival motor neuron (SMN) protein deficiency causes the genetic neuromuscular disorder spinal muscular atrophy (SMA), characterized by spinal cord motoneuron degeneration. Since SMN protein level is critical to disease ...
    • Regulation of the cell integrity pathway by rapamycin-sensitive TOR function in budding yeast 

      Torres Rosell, Jordi; Di Como, Charles J.; Herrero Perpiñán, Enrique; Torre Ruiz, M. A. de la (The American Society for Biochemistry and Molecular Biology, 2002)
      The TOR (target of rapamycin) pathway controls cell growth in response to nutrient availability in eukary- otic cells. Inactivation of TOR function by rapamycin or nutrient exhaustion is accompanied by triggering various ...
    • Regulation of the Na+/K+-ATPase Ena1 Expression by Calcineurin/Crz1 under High pH Stress: a quantitative study 

      Petrezsélyová, Silvia; López Malo, María; Canadell, David; Roque, Alicia; Serra Cardona, Albert; Marqués, M. Carmen; Vilaprinyo Terré, Ester; Alves, Rui; Yenush, Lynne; Ariño Carmona, Joaquín (Public Library of Science, 2016)
      Regulated expression of the Ena1 Na+-ATPase is a crucial event for adaptation to high salt and/or alkaline pH stress in the budding yeast Saccharomyces cerevisiae. ENA1 expression is under the control of diverse signaling ...
    • Relationship of the adherence to the Mediterranean diet with health-related quality of life and treatment satisfaction in patients with type 2 diabetes mellitus: a post-hoc analysis of a cross-sectional study 

      Alcubierre Calvo, Núria; Martínez Alonso, Montserrat; Valls Marsal, Joan; Rubinat, Esther; Traveset Maeso, Alicia; Hernandez, Marta; Martínez González, María Dolores; Granado Casas, Minerva; Jurjo Campo, Carmen; Vioque, Jesus; Navarrete Muñoz, Eva María; Mauricio Puente, Dídac (BioMed Central, 2016)
      Objective: The main aim of this study was to assess the association between adherence to the traditional Mediterranean diet (MedDiet) and health-related quality of life (HRQoL) and treatment satisfaction in patients ...
    • Relative amino acid composition signatures of organisms and environments 

      Moura, Alexandra; Savageau, Michael A.; Alves, Rui (Public Library of Science, 2013)
      Background: Identifying organism-environment interactions at the molecular level is crucial to understanding how organisms adapt to and change the chemical and molecular landscape of their habitats. In this work we ...
    • Relevance of death receptors in nervous system: role in the pathogenesis of neurodegenerative diseases and targets for therapy 

      Segura Ginard, Miguel Francisco; Comella i Carnicé, Joan Xavier (Institut d'Estudis Catalans. Secció de Ciències i Tecnologia, 2008)
      L’apoptosi és un procés fisiològic que controla el nombre de cèl·lules en organismes superiors. L’apoptosi està estrictament regulada i s’ha vist que està implicada en la patogènesi d’algunes malalties del sistema nerviós. ...
    • Reporting of methodologic information on trial registries for quality assessment: a study of trial records retrieved from the WHO search portal 

      Reveiz, Ludovic; Chan, An-Wen; Krleza-Jeric, Karmela; Granados, Carlos Eduardo; Pinart, Mariona; Etxeandia, Itziar; Rada, Diego; Martínez Alonso, Montserrat; Bonfill, Xavier; Cardona, Andrés Felipe (Public Library of Science (PLoS), 2010)
      Background: Although randomized clinical trials (RCTs) are considered the gold standard of evidence, their reporting is often suboptimal. Trial registries have the potential to contribute important methodologic information ...
    • Reproducibility of measurement of myometrial invasion in endometrial carcinoma 

      van der Putten, Louis J. M.; van de Vijver, Koen; Bartosch, Carla; Davidson, Ben; Gatius Calderó, Sònia; Matias-Guiu, Xavier; McCluggage, W. Glenn; Toledo, Gemma; van der Wurff, Anneke A. M.; Pijnenborg, Johanna M. A.; Massuger, Leon F. A. G.; Bulten, Johan (Springer Berlin Heidelberg, 2016)
      Myometrial invasion (MI) as a percentage (%MI), categorized into <50 or ≥50 %, is an important predictor of prognosis in endometrial carcinoma. Recent studies suggest that tumor-free distance (TFD) to serosa and the absolute ...