Now showing items 340-359 of 523

    • Palbociclib has antitumour effects on Pten-deficient endometrial neoplasias 

      Dosil Garcia, Maria Alba; Mirantes Barbeito, Cristina; Eritja Sánchez, Núria; Felip, Isidre; Navaridas Fernández de Bobadilla, Raúl; Gatius Calderó, Sònia; Santacana Espasa, Maria; Colás, Eva; Moiola, Cristian P.; Schoenenberger, Joan Antoni; Encinas Martín, Mario; Garí Marsol, Eloi; Matias-Guiu, Xavier; Dolcet Roca, Xavier (Wiley, 2017-04-28)
      PTEN is one of the most frequently mutated genes in human cancers. The frequency of PTEN alterations is particularly high in endometrial carcinomas. Loss of PTEN leads to dysregulation of cell division, and promotes the ...
    • Pathologic Prognostic Factors in Endometrial Carcinoma (Other Than Tumor Type and Grade) 

      Singh, Naveena; Hirschowitz, Lynn; Zaino, Richard; Alvarado-Cabrero, Isabel; Duggan, Máire; Ali-Fehmi, Rouba; Euscher, Elizabeth; Hecht, Jonathan; Horn, Lars-Christian; Ioffe, Olga; Matias-Guiu, Xavier; McCluggage, W. Glenn; Mikami, Yoshiki; Ordi, Jaume; Parkash, Vinita; Quddus, M. Ruhul; Quick, Charles; Staebler, Annette; Zaloudek, Charles; Nucci, Marisa; Malpica, Anais; Oliva, Esther (Lippincott, Williams & Wilkins, 2019)
      Although endometrial carcinoma (EC) is generally considered to have a good prognosis, over 20% of women with EC die of their disease, with a projected increase in both incidence and mortality over the next few decades. The ...
    • Pathways to defense metabolites and evading fruit bitterness in genus Solanum evolved through 2-oxoglutarate-dependent dioxygenases 

      Cárdenas, Pablo D.; Sonawane, Prashant D.; Heinig, Uwe; Jozwiak, Adam; Panda, Sayantan; Abebie, Bekele; Kazachkova, Yana; Pliner, Margarita; Unger, Tamar; Wolf, Dalia; Ofner, Itai; Vilaprinyo Terré, Ester; Meir, Sagit; Davydov, Olga; Gal-on, Amit; Burdman, Saul; Gir, Ashok; Zamir, Dani; Scherf, Tali; Szymanski, Jedrzej; Rogachev, Ilana; Aharoni, Asaph (Springer Nature, 2019)
      The genus Solanum comprises three food crops (potato, tomato, and eggplant), which are consumed on daily basis worldwide and also producers of notorious anti-nutritional steroidal glycoalkaloids (SGAs). Hydroxylated SGAs ...
    • Patient-Derived Xenograft Models for Endometrial Cancer Research 

      Moiola, Cristian P.; Lopez-Gil, Carlos; Cabrera, Silvia; Garcia, Angel; Van Nyen, Tom; Annibali, Daniela; Fonnes, Tina; Vidal, August; Villanueva, Alberto; Matias-Guiu, Xavier; Krakstad, Camilla; Amant, Frederic; Gil-Moreno, Antonio; Colás, Eva (MDPI, 2018)
      Endometrial cancer (EC) is the most common malignancy of the genital tract among women in developed countries. Recently, a molecular classification of EC has been performed providing a system that, in conjunction with ...
    • Percepción del aborto: voces de los médicos en el Hospital de San José (Bogotá) 

      Laza-Vásquez, Celmira; Castiblanco Montañez, Ruth Alexandra (Universidad de Antioquia, 2017-01-20)
      Objetivo: Comprender la percepción acerca de la interrupción voluntaria del embarazo (ive), bajo las tres causales definidas en la Sentencia C-355 del 2006, en un grupo de médicos del Hospital de San José, Bogotá-Colombia. ...
    • Percepción del estado de salud en varones y mujeres en las últimas etapas de la vida 

      Séculi, E.; Fusté Sugrañes, Josep; Brugulat, Pilar; Juncà, S.; Rué i Monné, Montserrat; Guillén, M. (Elsevier España, 2001)
      Objetivo: Analizar las diferencias en la percepción del estado de salud de los varones y mujeres en las últimas etapas de la vida y explorar su relación con variables sociodemográficas y de salud. Métodos: Datos ...
    • Perioperative glycaemic control for diabetic patients undergoing surgery 

      Buchleitner, AM; Martínez Alonso, Montserrat; Hernández García, Marta; Solà, Ivan; Mauricio Puente, Dídac (John Wiley & Sons, 2012)
      Background Patients with diabetes mellitus are at increased risk of postoperative complications. Data from randomised clinical trials and metaanalyses point to a potential benefit of intensive glycaemic control, targeting ...
    • Peritoneal Dialysis Is an Independent Factor Associated to Lower Intima Media Thickness in Dialysis Patients Free From Previous Cardiovascular Disease 

      Borràs, Mercè; Cambray Carner, Serafí; Crespo Masip, Maria; Pérez Fontán, Miguel; Bozić Stanojević, Milica; Bermúdez López, Marcelino; Fernández i Giráldez, Elvira; Betriu i Bars, M. Àngels; Valdivielso Revilla, José Manuel (Frontiers Media, 2018)
    • Phase III Study of PSC-833 (Valspodar) in Combination with Vincristine, Doxorubicin, and Dexamethasone (Valspodar/VAD) versus VAD Alone in Patients with Recurring or Refractory Multiple Myeloma (E1A95) 

      Friedenberg, William R.; Rué i Monné, Montserrat; Blood, Emily; Dalton, William S.; Shustik, Chaim; Larson, Richard A.; Sonneveld, Pieter; Greipp, Philip R. (Wiley, 2006)
      BACKGROUND. Preliminary studies have shown valspodar (PSC-833: Novartis Pharmaceuticals, East Hanover, NJ) to be a potent inhibitor of multidrug resistance (MDR), one cause of resistance to chemotherapy. An international ...
    • Phosphorylated Tyr142 β-catenin localizes to centrosomes and is regulated by Syk 

      Bhardwaj, Deepshikha; Nàger Grifo, Mireia; Visa Pretel, Anna; Crespí Sallán, Marta; Coopman, PJ; Cantí Nicolás, Carles; Herreros Danés, Judit (Willey, 2018-04-01)
      β-catenin is a central component of adherent junctions and a key effector of canonical Wnt signalling, in which dephosphorylated Ser/Thr β-catenin regulates gene transcription. β-catenin phosphorylation at Tyr142 (PTyr142 ...
    • Phosphorylation of Hsl1 by Hog1 leads to a G2 arrest essential for cell survival at high osmolarity 

      Clotet Bellmunt, Josep; Escoté, Xavier; Àngel Adrover, Miquel; Yaakov, Gilad; Garí Marsol, Eloi; Aldea, Martí; de Nadal, Eulàlia; Posas, Francesc (EMBOPress, 2006)
      Control of cell cycle progression by stress-activated protein kinases (SAPKs) is essential for cell adaptation to extracellular stimuli. Exposure of yeast to osmostress leads to activation of the Hog1 SAPK, which controls ...
    • Physical Activity Behavior, Aerobic Fitness and Quality of Life in School-Age Children 

      Serra Payà, Noemí; Ensenyat Solé, Assumpta; Serra Paya, Pau; Blanco Nespereira, Alfonso (Elsevier, 2015)
      The aim of this article is to assess the differences in sedentary and physical activity behavior, physical fitness and quality of lifein school-age children according to their adiposity state (BMI-SD= Body Mass Index ...
    • Physical interaction between the MAPK Slt2 of the PKC1-MAPK pathway and Grx3/Grx4 glutaredoxins is required for the oxidative stress response in budding yeast 

      Pujol Carrión, Núria; Torre Ruiz, M. A. de la (Elsevier, 2017)
      This study demonstrates that both monothiol glutaredoxins Grx3 and Grx4 physically interact with the MAPK Slt2 forming a complex involved in the cellular response to oxidative stress. The simultaneous absence of Grx3 and ...
    • Pkc1 and the upstream elements of the cell integrity pathway in Saccharomyces cerevisiae, Rom2 and Mtl1, are required for cellular responses to oxidative stress 

      Vilella Mitjana, Felipe; Herrero Perpiñán, Enrique; Torres Rosell, Jordi; Torre Ruiz, M. A. de la (The American Society for Biochemistry and Molecular Biology, 2005)
      In this study we analyze the participation of the PKC1-MAPK cell integrity pathway in cellular re- sponses to oxidative stress in Saccharomyces cerevisiae. Evidence is presented demonstrating that only Pkc1 and the ...
    • Plant-derived phenolics inhibit the accrual of structurally characterised protein and lipid oxidative modifications 

      Soler Cantero, Arantza; Jové Font, Mariona; Cacabelos Barral, Daniel; Boada Pallàs, Jordi; Naudí i Farré, Alba; Romero Fabregat, Mª Paz; Cassanyé, Anna; Serrano Casasola, José Carlos Enrique; Arola i Ferrer, Lluís; Valls, Josep; Bellmunt i Curcó, Josepa; Prat Corominas, Joan; Pamplona Gras, Reinald; Portero Otín, Manuel; Motilva Casado, Mª José (Public Library of Science, 2012)
      Epidemiological data suggest that plant-derived phenolics beneficial effects include an inhibition of LDL oxidation. After applying a screening method based on 2,4-dinitrophenyl hydrazine- protein carbonyl reaction to 21 ...
    • Plasma profiling reveals a blood-based metabolic fingerprint of obstructive sleep apnea 

      Pinilla Latorre, Lucía; Benitez, Ivan; Santamaría Martos, Fernando; Targa, Adriano; Moncusí Moix, Anna; Dalmases Cleries, Mireia; Minguez Roure, Olga; Aguilà, Maria; Jové Font, Mariona; Sol, Joaquim; Pamplona Gras, Reinald; Barbé Illa, Ferran; Sánchez de la Torre, Manuel (Elsevier, 2022)
      Introduction: Obstructive sleep apnea (OSA) is a chronic, heterogeneous and multicomponent disorder with associated cardiovascular and metabolic alterations. Despite being the most common sleep-disordered breathing, it ...
    • Pleiotropic analysis of lung cancer and blood triglycerides 

      Zuber, Verena; Marconett, Crystal N.; Shi, Jianxin; Hua, Xing; Wheeler, William; Yang, Chenchen; Song, Lei; Dale, Anders M.; Laplana Lafaja, Marina; Risch, Angela; Witoelar, Aree; Thompson, Wesley K.; Schork, Andrew J.; Bettella, Francesco; Wang, Yunpeng; Djurovic, Srdjan; Zhou, Beiyun; Borok, Zea; van der Heijden, Henricus F. M.; Graaf, Jacqueline de; Swinkels, Dorine; Aben, Katja K.; McKay, James D.; Hung, Rayjean J.; Bikeböller, Heike; Stevens, Victoria L.; Albanes, Demetrius; Caporaso, Neil E.; Han, Younghun; Wei, Yongyue; Panadero, Maria Ángeles; Mayordomo, José I.; Christiani, David C.; Kiemeney, Lambertus; Andreassen, O. A.; Houlston, Richard; Amos, Christopher I.; Chatterjee, Nilanjan; Laird-Offringa, Ite A.; Mills, Ian G.; Landi, Maria Teresa (Oxford University Press, 2016)
      Epidemiologically related traits may share genetic risk factors, and pleiotropic analysis could identify individual loci associated with these traits. Because of their shared epidemiological associations, we conducted ...
    • Plurality of opinion, scientific discourse and pseudoscience: an in depth analysis of the Séralini et al. study claiming that Roundup™ Ready corn or the herbicide Roundup™ cause cancer in rats 

      Arjó Pont, Gemma; Portero Otín, Manuel; Piñol Felis, Carme; Viñas Salas, Joan; Matias-Guiu, Xavier; Capell Capell, Teresa; Bartholomaeus, Andrew; Parrot, Wayne; Christou, Paul (Springer Verlag, 2013)
      A recent paper published in the journal Food and Chemical Toxicology presents the results of a long-term toxicity study related to a widely-used commercial herbicide (RoundupTM) and a Rounduptolerant genetically modified ...
    • Polyphosphate is a key factor for cell survival after DNA damage in eukaryotic cells 

      Bru, Samuel; Samper Martín, Bàrbara; Quandt, Eva; Hernández Ortega, Sara; Martínez Laínez, Joan M; Garí Marsol, Eloi; Rafel i Borrell, Marta; Torres Torronteras, Javier; Martí, Ramón; Ribeiro, Mariana; Jiménez, Javier; Clotet, Josep (Elsevier, 2017-08-08)
      Cells require extra amounts of dNTPs to repair DNA after damage. Polyphosphate (polyP) is an evolutionary conserved linear polymer of up to several hundred inorganic phosphate (Pi) residues that is involved in many functions, ...
    • Polypyrimidine tract binding proteins (PTB) regulate the expression of apoptotic genes and susceptibility to caspase-dependent apoptosis in differentiating cardiomyocytes 

      Zhang, Jisheng; Bahi i Pla, Núria; Comella i Carnicé, Joan Xavier; Sanchis, Daniel (Nature Publishing Group, 2009)
      Cardiac morphologic abnormalities in mice deficient for key regulators of the caspase-dependent signaling underscored its role in heart development. However, the mechanisms regulating apoptotic gene expression in the ...