Now showing items 321-340 of 502

    • Obstructive Sleep Apnea: Emerging Treatments Targeting the Genioglossus Muscle 

      Mediano, Olga; Romero-Peralta, Sofia; Resano, Pilar; Cano-Pumarega, Irene; Sánchez de la Torre, Manuel; Castillo-García, María; Martínez-Sánchez, Ana Belén; Ortigado, Ana; García-Río, Francisco (MDPI, 2019)
      Obstructive sleep apnea (OSA) is characterized by repetitive episodes of upper airway obstruction caused by a loss of upper airway dilator muscle tone during sleep and an inadequate compensatory response by these muscles ...
    • Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer 

      Signoretti, Sabina; Di Marcotullio, Lucia; Richardson, Andrea; Ramaswamy, Sridhar; Isaac, Beth; Rué i Monné, Montserrat; Monti, Franco; Loda, Massimo; Pagano, Michele (American Society for Clinical Investigation, 2002)
      Estrogen receptor (ER) expression and Her-2 amplification define specific subsets of breast tumors for which specific therapies exist. The S-phase kinase-associated protein Skp2 is required for the ubiquitin-mediated degradation ...
    • Optimal protocol for PTEN immunostaining; role of analytical and preanalytical variables in PTEN staining in normal and neoplastic endometrial, breast, and prostatic tissues 

      Maiques Carlos, Oscar; Santacana Espasa, Maria; Valls Marsal, Joan; Pallares, Judit; Mirantes Barbeito, Cristina; Gatius Calderó, Sònia; García Dios, Diego Andrés; Amant, Frederic; Pedersen, Hans Christian; Dolcet Roca, Xavier; Matias-Guiu, Xavier (Elsevier, 2014)
      In some tumors, phosphatase and tensin homolog (PTEN) inactivation may have prognostic importance and predictive value for targeted therapies. Immunohistochemistry (IHC) may be an effective method to demonstrate PTEN loss. ...
    • ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins 

      Hjelmqvist, Lars; Tuson, Miquel; Marfany i Nadal, Gemma; Herrero Perpiñán, Enrique; Balcells Comas, Susana; González, Roser (BioMed Central, 2002)
      Background: Annotations of completely sequenced genomes reveal that nearly half of the genes identified are of unknown function, and that some belong to uncharacterized gene families. To help resolve such issues, information ...
    • Osmotic stress causes a G1 cell cycle delay and downregulation of Cln3/Cdc28 activity in Saccharomyces cerevisiae 

      Bellí i Martínez, Gemma; Garí Marsol, Eloi; Aldea, Martí; Herrero Perpiñán, Enrique (Blackwell Science, 2001)
      Moderate hyperosmotic stress on Saccharomyces cerevisiae cells produces a temporary delay at the G1 stage of the cell cycle. This is accompanied by transitory downregulation of CLN1, CLN2 and CLB5 transcript levels, ...
    • Outcomes of a randomized trial of hyperfractionated cranial radiation therapy for treatment of high-risk acute lymphoblastic leukemia: therapeutic efficacy and neurotoxicity 

      Waber, Deborah P.; Silverman, Lewis B.; Catania, Lori; Mautz, William; Rué i Monné, Montserrat; Gelber, Richard D.; Levy, Donna E.; Goldwasser, Meredith A.; Adams, Heather; Dufresne, Annie; Metzger, Victoria; Romero, Ivonne; Tarbell, Nancy J.; Dalton, Virginia; Sallan, Stephen E. (American Society of Clinical Oncology, 2004)
      Purpose We evaluated 8-year survival and late neuropsychologic toxicity in children with acute lymphoblastic leukemia treated in a randomized clinical trial to test whether hyperfractionated (twice daily) cranial radiation ...
    • Oxidative Damage to Specific Proteins in Replicative and Chronological-aged Saccharomyces cerevisiae 

      Reverter Branchat, Gemma; Cabiscol Català, Elisa; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim (American Society for Biochemistry and Molecular Biology, 2004)
      Oxidative modifications of cellular components have been described as one of the main contributions to aged phenotype. In Saccharomyces cerevisiae, two distinct life spans can be considered, replicative and chronological. The ...
    • Oxidative stress in bacteria and protein damage by reactive oxygen species 

      Cabiscol Català, Elisa; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim (Springer-Verlag Ibérica, 2000)
      The advent of O2 in the atmosphere was among the first major pollution events occurred on earth. The reaction between ferrous iron, very abundant in the reductive early atmosphere, and oxygen results in the formation of ...
    • Oxidative stress promotes specific protein damage in Saccharomyces cerevisiae 

      Cabiscol Català, Elisa; Piulats Combalia, Eva; Echave Lozano, Pedro; Herrero Perpiñán, Enrique; Ros Salvador, Joaquim (The American Society for Biochemistry and Molecular Biology, 2000)
      We have analyzed the proteins that are oxidatively damaged when Saccharomyces cerevisiae cells are ex- posed to stressing conditions. Carbonyl groups generated by hydrogen peroxide or menadione on proteins of aero- bically ...
    • Palbociclib has antitumour effects on Pten-deficient endometrial neoplasias 

      Dosil Garcia, Maria Alba; Mirantes Barbeito, Cristina; Eritja Sánchez, Núria; Felip, Isidre; Navaridas Fernández de Bobadilla, Raúl; Gatius Calderó, Sònia; Santacana Espasa, Maria; Colás, Eva; Moiola, Cristian P.; Schoenenberger, Joan Antoni; Encinas Martín, Mario; Garí Marsol, Eloi; Matias-Guiu, Xavier; Dolcet Roca, Xavier (Wiley, 2017-04-28)
      PTEN is one of the most frequently mutated genes in human cancers. The frequency of PTEN alterations is particularly high in endometrial carcinomas. Loss of PTEN leads to dysregulation of cell division, and promotes the ...
    • Pathologic Prognostic Factors in Endometrial Carcinoma (Other Than Tumor Type and Grade) 

      Singh, Naveena; Hirschowitz, Lynn; Zaino, Richard; Alvarado-Cabrero, Isabel; Duggan, Máire; Ali-Fehmi, Rouba; Euscher, Elizabeth; Hecht, Jonathan; Horn, Lars-Christian; Ioffe, Olga; Matias-Guiu, Xavier; McCluggage, W. Glenn; Mikami, Yoshiki; Ordi, Jaume; Parkash, Vinita; Quddus, M. Ruhul; Quick, Charles; Staebler, Annette; Zaloudek, Charles; Nucci, Marisa; Malpica, Anais; Oliva, Esther (Lippincott, Williams & Wilkins, 2019)
      Although endometrial carcinoma (EC) is generally considered to have a good prognosis, over 20% of women with EC die of their disease, with a projected increase in both incidence and mortality over the next few decades. The ...
    • Pathways to defense metabolites and evading fruit bitterness in genus Solanum evolved through 2-oxoglutarate-dependent dioxygenases 

      Cárdenas, Pablo D.; Sonawane, Prashant D.; Heinig, Uwe; Jozwiak, Adam; Panda, Sayantan; Abebie, Bekele; Kazachkova, Yana; Pliner, Margarita; Unger, Tamar; Wolf, Dalia; Ofner, Itai; Vilaprinyo Terré, Ester; Meir, Sagit; Davydov, Olga; Gal-on, Amit; Burdman, Saul; Gir, Ashok; Zamir, Dani; Scherf, Tali; Szymanski, Jedrzej; Rogachev, Ilana; Aharoni, Asaph (Springer Nature, 2019)
      The genus Solanum comprises three food crops (potato, tomato, and eggplant), which are consumed on daily basis worldwide and also producers of notorious anti-nutritional steroidal glycoalkaloids (SGAs). Hydroxylated SGAs ...
    • Patient-Derived Xenograft Models for Endometrial Cancer Research 

      Moiola, Cristian P.; Lopez-Gil, Carlos; Cabrera, Silvia; Garcia, Angel; Van Nyen, Tom; Annibali, Daniela; Fonnes, Tina; Vidal, August; Villanueva, Alberto; Matias-Guiu, Xavier; Krakstad, Camilla; Amant, Frederic; Gil-Moreno, Antonio; Colás, Eva (MDPI, 2018)
      Endometrial cancer (EC) is the most common malignancy of the genital tract among women in developed countries. Recently, a molecular classification of EC has been performed providing a system that, in conjunction with ...
    • Percepción del aborto: voces de los médicos en el Hospital de San José (Bogotá) 

      Laza-Vásquez, Celmira; Castiblanco Montañez, Ruth Alexandra (Universidad de Antioquia, 2017-01-20)
      Objetivo: Comprender la percepción acerca de la interrupción voluntaria del embarazo (ive), bajo las tres causales definidas en la Sentencia C-355 del 2006, en un grupo de médicos del Hospital de San José, Bogotá-Colombia. ...
    • Percepción del estado de salud en varones y mujeres en las últimas etapas de la vida 

      Séculi, E.; Fusté Sugrañes, Josep; Brugulat, Pilar; Juncà, S.; Rué i Monné, Montserrat; Guillén, M. (Elsevier España, 2001)
      Objetivo: Analizar las diferencias en la percepción del estado de salud de los varones y mujeres en las últimas etapas de la vida y explorar su relación con variables sociodemográficas y de salud. Métodos: Datos ...
    • Perioperative glycaemic control for diabetic patients undergoing surgery 

      Buchleitner, AM; Martínez Alonso, Montserrat; Hernández García, Marta; Solà, Ivan; Mauricio Puente, Dídac (John Wiley & Sons, 2012)
      Background Patients with diabetes mellitus are at increased risk of postoperative complications. Data from randomised clinical trials and metaanalyses point to a potential benefit of intensive glycaemic control, targeting ...
    • Peritoneal Dialysis Is an Independent Factor Associated to Lower Intima Media Thickness in Dialysis Patients Free From Previous Cardiovascular Disease 

      Borràs, Mercè; Cambray Carner, Serafí; Crespo Masip, Maria; Pérez Fontán, Miguel; Bozić Stanojević, Milica; Bermúdez López, Marcelino; Fernández i Giráldez, Elvira; Betriu i Bars, M. Àngels; Valdivielso Revilla, José Manuel (Frontiers Media, 2018)
    • Phase III Study of PSC-833 (Valspodar) in Combination with Vincristine, Doxorubicin, and Dexamethasone (Valspodar/VAD) versus VAD Alone in Patients with Recurring or Refractory Multiple Myeloma (E1A95) 

      Friedenberg, William R.; Rué i Monné, Montserrat; Blood, Emily; Dalton, William S.; Shustik, Chaim; Larson, Richard A.; Sonneveld, Pieter; Greipp, Philip R. (Wiley, 2006)
      BACKGROUND. Preliminary studies have shown valspodar (PSC-833: Novartis Pharmaceuticals, East Hanover, NJ) to be a potent inhibitor of multidrug resistance (MDR), one cause of resistance to chemotherapy. An international ...
    • Phosphorylated Tyr142 β-catenin localizes to centrosomes and is regulated by Syk 

      Bhardwaj, Deepshikha; Nàger Grifo, Mireia; Visa Pretel, Anna; Crespí Sallán, Marta; Coopman, PJ; Cantí Nicolás, Carles; Herreros Danés, Judit (Willey, 2018-04-01)
      β-catenin is a central component of adherent junctions and a key effector of canonical Wnt signalling, in which dephosphorylated Ser/Thr β-catenin regulates gene transcription. β-catenin phosphorylation at Tyr142 (PTyr142 ...
    • Phosphorylation of Hsl1 by Hog1 leads to a G2 arrest essential for cell survival at high osmolarity 

      Clotet Bellmunt, Josep; Escoté, Xavier; Àngel Adrover, Miquel; Yaakov, Gilad; Garí Marsol, Eloi; Aldea, Martí; de Nadal, Eulàlia; Posas, Francesc (EMBOPress, 2006)
      Control of cell cycle progression by stress-activated protein kinases (SAPKs) is essential for cell adaptation to extracellular stimuli. Exposure of yeast to osmostress leads to activation of the Hog1 SAPK, which controls ...