Browsing Articles publicats (Ciències Mèdiques Bàsiques) by Title
Now showing items 282-301 of 524
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L1CAM expression in uterine carcinosarcoma is limited to the epithelial component and may be involved in epithelial–mesenchymal transition
(Springer Verlag, 2018)Uterine carcinosarcoma (UCS) has been proposed as a model for epithelial–mesenchymal transition (EMT), a process characterized by a functional change facilitating migration and metastasis in many types of cancer. L1CAMis ... -
Lack of protective effect of chloroquine derivatives on COVID-19 disease in a Spanish sample of chronically treated patients
(2020)Background The search for a SARS-CoV-2 treatment has emerged as a worldwide priority. We evaluated the role of chloroquine and its derivatives in COVID-19 in Spanish individuals. Methods We performed a survey addressed ... -
Lack of protective effect of chloroquine derivatives on COVID-19 disease in a Spanish sample of chronically treated patients
(Public Library of Science, 2020)Background The search for a SARS-CoV-2 treatment has emerged as a worldwide priority. We evaluated the role of chloroquine and its derivatives in COVID-19 in Spanish individuals. Methods We performed a survey addressed ... -
Local juvenile hormone activity regulates gut homeostasis and tumor growth in adult Drosophila
(Nature Publishing Group, 2017-09-15)Hormones play essential roles during development and maintaining homeostasis in adult organisms, regulating a plethora of biological processes. Generally, hormones are secreted by glands and perform a systemic action. Here ... -
Long-term Effect of CPAP Treatment on Cardiovascular Events in Patients With Resistant Hypertension and Sleep Apnea. Data From the HIPARCO-2 Study
(Elsevier, 2020)Background: There is some controversy about the effect of continuous positive airway pressure (CPAP) on the incidence of cardiovascular events (CVE). However, the incidence of CVE among patients with both obstructive sleep ... -
Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation
(Springer Nature, 2019)In the presence of aggregation-prone proteins, the cytosol and endoplasmic reticulum (ER) undergo a dramatic shift in their respective redox status, with the cytosol becoming more oxidized and the ER more reducing. However, ... -
Low Doses of EPO Activate MAP Kinases but Not JAK2–STAT5 in Rat Vascular Smooth Muscle Cells
(Elsevier, 2001)Previous reports have shown a direct effect of erythropoietin (Epo) on vascular smooth muscle cells (VSMCs). Our aim was to assess expression of the Epo receptor (EpoR) on VSMCs and to study the activation of two major ... -
Low-Carbohydrate diet for the treatment of gestational Diabetes Mellitus
(American Diabetes Association, 2013)OBJECTIVE: Medical nutrition therapy based on the control of the amount and distribution of carbohydrates (CHO) is the initial treatment for gestational diabetes mellitus (GDM), but there is a need for randomized controlled ... -
Lung cancer mortality among males of Catalonia and Spain compared with other European countries between 1975-1977 and 1987-1989
(Wiley, 1996)This study compares the lung cancer mortality rates among males in the years 1975- I977 and 1987- I989 in Catalonia and Spain with other European countries selected for their geographical proximity. Adjusted calculations ... -
Major targets of iron-induced protein oxidative damage in frataxin-deficient yeasts are magnesium-binding proteins
(Elsevier, 2008)Iron accumulation has been associated with several pathological conditions such as Friedreich ataxia. This human disorder is caused by decreased expression of frataxin. Iron-overload triggers oxidative stress, but the ... -
Manganese Is the Link between Frataxin and Iron-Sulfur Deficiency in the Yeast Model of Friedreich Ataxia
(American Society for Biochemistry and Molecular Biology, 2006)Friedreich ataxia is a human neurodegenerative and myocardial disease caused by decreased expression of the mitochondrial protein frataxin. Proteomic analysis of the mutant yeast model of Friedreich ataxia presented in ... -
Maximization of information transmission influences selection of native phosphorelay architectures
(PeerJ, 2021)Phosphorelays are signal transduction circuits that sense environmental changes and adjust cellular metabolism. Five different circuit architectures account for 99% of all phosphorelay operons annotated in over 9,000 ... -
Mental health expectancy: an indicator to bridge the gap between clinical and public health perspectives of population mental health.
(Wiley, 1998)Mental health indicators generally used in public health are derived from mortality statistics, but they do not reflect the impact that disability due to mental disorders has on population health. The present study ... -
Metabolic remodeling in frataxin-deficient yeast is mediated by Cth2 and Adr1
(Elsevier, 2013)Frataxin is a mitochondrial protein involved in iron metabolism whose deficiency in humans causes Friedreich ataxia. We performed transcriptomic and proteomic analyses of conditional Yeast Frataxin Homologue (Yfh1) mutants ... -
Metabolomic and lipidomic profiling identifies the role of the RNA editing pathway in endometrial carcinogenesis
(Nature Publishing Group, 2017)Endometrial cancer (EC) remains the most common malignancy of the genital tract among women in developed countries. Although much research has been performed at genomic, transcriptomic and proteomic level, there is still ... -
Metabolomics predicts neuroimaging characteristics of transient ischemic attack patients
(Elsevier, 2016)Background: Neuroimaging is essential for the diagnosis and prognosis of transient ischemic attack (TIA). The discovery of a plasmatic biomarker related to neuroimaging findings is of enormous interest because, despite ... -
Metabolomics predicts stroke recurrence after transient ischemic attack
(American Academy of Neurology, 2015)Objective: To discover, by using metabolomics, novel candidate biomarkers for stroke recurrence (SR) with a higher prediction power than present ones. Methods: Metabolomic analysis was performed by liquid chromatography ... -
Metabotyping human endometrioid endometrial adenocarcinoma reveals an implication of endocannabinoid metabolism
(Impact Journals, 2016)Metabolomics, an essential technique in precision medicine, contributes to the molecular fingerprinting of tumours, further helping to understand their pathogenesis. In this work, using a LC-ESI-QTOF-MS/MS platform, we ... -
Metal-catalyzed Oxidation of Fe2+ Dehydrogenases: consensus target sequence between Propanediol Oxidoreductase of Escherichia Coli and alcohol dehydrogenase I1 of Zymomonas Mobilis
(American Society for Biochemistry and Molecular Biology, 1994)We have studied two enzymes of a newly described family of dehydrogenases with high sequence homology, 1,2-propanediol oxidoreductase of Escherichia coli and alcohol dehydrogenase II of Zymomonas mobilis. These enzymes ... -
Metàstasis de melanoma maligne en nòduls pulmonar múltiples
(Societat Catalana de Citopatologia, 2019-10)