Now showing items 302-321 of 559

    • L1CAM expression in uterine carcinosarcoma is limited to the epithelial component and may be involved in epithelial–mesenchymal transition 

      Versluis, MAC; Plat, A; de Bruyn, M; Matias-Guiu, Xavier; Trovik, Jone; Krakstad, Camilla; Nijman, Hans W.; Bosse, Tjalling; de Bock, GH; Hollema, H (Springer Verlag, 2018)
      Uterine carcinosarcoma (UCS) has been proposed as a model for epithelial–mesenchymal transition (EMT), a process characterized by a functional change facilitating migration and metastasis in many types of cancer. L1CAMis ...
    • Lack of protective effect of chloroquine derivatives on COVID-19 disease in a Spanish sample of chronically treated patients 

      Laplana Lafaja, Marina; Yuguero Torres, Oriol; Fibla Palazón, Joan (Public Library of Science, 2020)
      Background The search for a SARS-CoV-2 treatment has emerged as a worldwide priority. We evaluated the role of chloroquine and its derivatives in COVID-19 in Spanish individuals. Methods We performed a survey addressed ...
    • Lack of protective effect of chloroquine derivatives on COVID-19 disease in a Spanish sample of chronically treated patients 

      Laplana Lafaja, Marina; Yuguero Torres, Oriol; Fibla Palazón, Joan (2020)
      Background The search for a SARS-CoV-2 treatment has emerged as a worldwide priority. We evaluated the role of chloroquine and its derivatives in COVID-19 in Spanish individuals. Methods We performed a survey addressed ...
    • Local juvenile hormone activity regulates gut homeostasis and tumor growth in adult Drosophila 

      Rahman, M.M.; Franch-Marro, X.; Maestro, J.L.; Martin, D.; Casali, Andreu (Nature Publishing Group, 2017-09-15)
      Hormones play essential roles during development and maintaining homeostasis in adult organisms, regulating a plethora of biological processes. Generally, hormones are secreted by glands and perform a systemic action. Here ...
    • Long-term Effect of CPAP Treatment on Cardiovascular Events in Patients With Resistant Hypertension and Sleep Apnea. Data From the HIPARCO-2 Study 

      Navarro-Soriano, Cristina; Martínez-García, Miguel Angel; Torres, Gerard; Barbé Illa, Ferran; Sánchez de la Torre, Manuel; Caballero-Eraso, Candela; Lloberes, Patricia; Díaz Cambriles, Trinidad; Somoza, María; Masa, Juan Fernando; González, Mónica; Mañas, Eva; de la Pena, Mónica; García-Río, Francisco; Montserrat, Josep Maria; Muriel, Alfonso; Oscullo, Grace; García-Ortega, Alberto; Posadas, Tomás; Campos-Rodríguez, Francisco; Spanish Sleep Network (Elsevier, 2020)
      Background: There is some controversy about the effect of continuous positive airway pressure (CPAP) on the incidence of cardiovascular events (CVE). However, the incidence of CVE among patients with both obstructive sleep ...
    • Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation 

      Guerrero-Gómez, David; Mora-Lorca, José Antonio; Sáenz-Narciso, Beatriz; Naranjo-Galindo, Francisco José; Muñoz-Lobato, Fernando; Parrado-Fernández, Cristina; Goikolea, Julen; Cedazo-Minguez, Ángel; Link, Christopher D.; Neri, Christian; Sequedo, María Dolores; Vázquez-Manrique, Rafael P.; Fernández-Suárez, Elena; Goder, Veit; Pane Domenec, Roser; Cabiscol Català, Elisa; Askjaer, Peter; Cabello, Juan; Miranda-Vizuete, Antonio (Springer Nature, 2019)
      In the presence of aggregation-prone proteins, the cytosol and endoplasmic reticulum (ER) undergo a dramatic shift in their respective redox status, with the cytosol becoming more oxidized and the ER more reducing. However, ...
    • Low Doses of EPO Activate MAP Kinases but Not JAK2–STAT5 in Rat Vascular Smooth Muscle Cells 

      Ammarguellat, Fatima; Llovera i Tomàs, Marta; Kelly, Paul A.; Goffin, Vincent (Elsevier, 2001)
      Previous reports have shown a direct effect of erythropoietin (Epo) on vascular smooth muscle cells (VSMCs). Our aim was to assess expression of the Epo receptor (EpoR) on VSMCs and to study the activation of two major ...
    • Low-Carbohydrate diet for the treatment of gestational Diabetes Mellitus 

      Moreno Castilla, Cristina; Hernandez, Marta; Bergua, Mercè; Álvarez, Maria C.; Arce, Maria A.; Rodríguez, Karen; Martínez Alonso, Montserrat; Iglesias Durán, Montserrat; Mateu, Magdalena; Santos, María Dolores; Pacheco, Linda R.; Blasco, Yolanda; Martín, Eva; Balsells, Núria; Aranda, Núria; Mauricio Puente, Dídac (American Diabetes Association, 2013)
      OBJECTIVE: Medical nutrition therapy based on the control of the amount and distribution of carbohydrates (CHO) is the initial treatment for gestational diabetes mellitus (GDM), but there is a need for randomized controlled ...
    • Lung cancer mortality among males of Catalonia and Spain compared with other European countries between 1975-1977 and 1987-1989 

      Bonfill, Xavier; Moreno, Coloma; Prada, Gonzalo; Rivero, Elena; Rué i Monné, Montserrat (Wiley, 1996)
      This study compares the lung cancer mortality rates among males in the years 1975- I977 and 1987- I989 in Catalonia and Spain with other European countries selected for their geographical proximity. Adjusted calculations ...
    • Machine learning analysis of serum biomarkers for cardiovascular risk assessment in chronic kidney disease 

      Forné Izquierdo, Carles; Cambray Carner, Serafí; Bermúdez López, Marcelino; Fernández i Giráldez, Elvira; Bozić Stanojević, Milica; Valdivielso Revilla, José Manuel (Oxford University Press, 2019)
      Background. Chronic kidney disease (CKD) patients show an increased burden of atherosclerosis and high risk of cardiovascular events (CVEs). There are several biomarkers described as being associated with CVEs, but their ...
    • Magnesium Levels Modify the Effect of Lipid Parameters on Carotid Intima Media Thickness 

      Cambray Carner, Serafí; Ibarz Escuer, Mercedes; Bermúdez López, Marcelino; Marti Antonio, Manuel; Bozić Stanojević, Milica; Fernández i Giráldez, Elvira; Valdivielso Revilla, José Manuel (MDPI, 2020)
      Classical risk factors of atherosclerosis in the general population show paradoxical effects in chronic kidney disease (CKD) patients. Thus, low low-density lipoprotein (LDL) cholesterol levels have been associated with ...
    • Major targets of iron-induced protein oxidative damage in frataxin-deficient yeasts are magnesium-binding proteins 

      Irazusta, Verónica Patricia; Moreno Cermeño, Armando J.; Cabiscol Català, Elisa; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (Elsevier, 2008)
      Iron accumulation has been associated with several pathological conditions such as Friedreich ataxia. This human disorder is caused by decreased expression of frataxin. Iron-overload triggers oxidative stress, but the ...
    • Manganese Is the Link between Frataxin and Iron-Sulfur Deficiency in the Yeast Model of Friedreich Ataxia 

      Irazusta, Verónica Patricia; Cabiscol Català, Elisa; Reverter Branchat, Gemma; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (American Society for Biochemistry and Molecular Biology, 2006)
      Friedreich ataxia is a human neurodegenerative and myocardial disease caused by decreased expression of the mitochondrial protein frataxin. Proteomic analysis of the mutant yeast model of Friedreich ataxia presented in ...
    • Maximization of information transmission influences selection of native phosphorelay architectures 

      Alves, Rui; Salvadó López, Baldiri; Milo, Ron; Vilaprinyo Terré, Ester; Sorribas Tello, Albert (PeerJ, 2021)
      Phosphorelays are signal transduction circuits that sense environmental changes and adjust cellular metabolism. Five different circuit architectures account for 99% of all phosphorelay operons annotated in over 9,000 ...
    • Mental health expectancy: an indicator to bridge the gap between clinical and public health perspectives of population mental health. 

      Gispert i Magarolas, Rosa; Ritchie, K.; Rajmil, L.; Rué i Monné, Montserrat; Glutting, J. P. (Wiley, 1998)
      Mental health indicators generally used in public health are derived from mortality statistics, but they do not reflect the impact that disability due to mental disorders has on population health. The present study ...
    • Metabolic remodeling in frataxin-deficient yeast is mediated by Cth2 and Adr1 

      Moreno Cermeño, Armando J.; Alsina Obiols, David; Cabiscol Català, Elisa; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim (Elsevier, 2013)
      Frataxin is a mitochondrial protein involved in iron metabolism whose deficiency in humans causes Friedreich ataxia. We performed transcriptomic and proteomic analyses of conditional Yeast Frataxin Homologue (Yfh1) mutants ...
    • Metabolomic and lipidomic profiling identifies the role of the RNA editing pathway in endometrial carcinogenesis 

      Altadill, Tatiana; Dowdy, Tyrone M.; Gill, Kirandeep; Reques, Armando; Menon, Smrithi S.; Moiola, Cristian P.; Lopez-Gil, Carlos; Coll, Eva; Matias-Guiu, Xavier; Cabrera, Silvia; Garcia, Angel; Reventós, Jaume; W. Byers, Stephen; Gil-Moreno, Antonio; Cheema, Amrita K.; Colás, Eva (Nature Publishing Group, 2017)
      Endometrial cancer (EC) remains the most common malignancy of the genital tract among women in developed countries. Although much research has been performed at genomic, transcriptomic and proteomic level, there is still ...
    • Metabolomics predicts neuroimaging characteristics of transient ischemic attack patients 

      Purroy Garcia, Francisco; Cambray Carner, Serafí; Mauri-Capdevila, Gerard; Jové Font, Mariona; Sanahuja Montesinos, Jordi; Farré, Joan; Benabdelhak Abbou, Ikram; Molina Seguin, Jessica; Colàs Campàs, Laura; Begué Gómez, Robert; Gil, M. Isabel; Pamplona Gras, Reinald; Portero Otín, Manuel (Elsevier, 2016)
      Background: Neuroimaging is essential for the diagnosis and prognosis of transient ischemic attack (TIA). The discovery of a plasmatic biomarker related to neuroimaging findings is of enormous interest because, despite ...
    • Metabolomics predicts stroke recurrence after transient ischemic attack 

      Jové Font, Mariona; Mauri-Capdevila, Gerard; Suárez-Luis, Idalmis; Cambray Carner, Serafí; Sanahuja Montesinos, Jordi; Quilez Martínez, Alejandro; Farré, Joan; Benabdelhak Abbou, Ikram; Pamplona Gras, Reinald; Portero Otín, Manuel; Purroy Garcia, Francisco (American Academy of Neurology, 2015)
      Objective: To discover, by using metabolomics, novel candidate biomarkers for stroke recurrence (SR) with a higher prediction power than present ones. Methods: Metabolomic analysis was performed by liquid chromatography ...
    • Metabotyping human endometrioid endometrial adenocarcinoma reveals an implication of endocannabinoid metabolism 

      Jové Font, Mariona; Gatius Calderó, Sònia; Yeramian Hakim, Andree; Portero Otín, Manuel; Eritja Sánchez, Núria; Santacana Espasa, Maria; Colás, Eva; Ruiz, M.; Pamplona Gras, Reinald; Matias-Guiu, Xavier (Impact Journals, 2016)
      Metabolomics, an essential technique in precision medicine, contributes to the molecular fingerprinting of tumours, further helping to understand their pathogenesis. In this work, using a LC-ESI-QTOF-MS/MS platform, we ...